Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA.
N-NTD
NMR
SARS-CoV-2
protein interaction
suramin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Mar 2023
10 Mar 2023
Historique:
received:
11
02
2023
revised:
07
03
2023
accepted:
08
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal domain of SARS-CoV-2 nucleocapsid protein (N-NTD) and disturb its interaction with RNA. The BLI experiments showed that N-NTD interacts suramin with a dissociate constant (K
Identifiants
pubmed: 36985506
pii: molecules28062534
doi: 10.3390/molecules28062534
pmc: PMC10051649
pii:
doi:
Substances chimiques
Suramin
6032D45BEM
Nucleocapsid Proteins
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of Fujian Province
ID : No. 2020J01022
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