Optimization of Host Cell-Compatible, Antimicrobial Peptides Effective against Biofilms and Clinical Isolates of Drug-Resistant Bacteria.
antibiotic
antimicrobial peptide
drug resistance
molecular evolution
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
14 04 2023
14 04 2023
Historique:
medline:
17
4
2023
pubmed:
25
3
2023
entrez:
24
3
2023
Statut:
ppublish
Résumé
Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called d-amino acid CONsensus with Glycine Absent (d-CONGA), which has excellent antimicrobial activities
Identifiants
pubmed: 36961222
doi: 10.1021/acsinfecdis.2c00640
pmc: PMC10111420
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Anti-Infective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
952-965Subventions
Organisme : NIAID NIH HHS
ID : R01 AI169344
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114697
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139930
Pays : United States
Références
Immunity. 2011 Dec 23;35(6):997-1009
pubmed: 22195749
Sci Transl Med. 2014 Sep 17;6(254):254ra126
pubmed: 25232178
PLoS One. 2010 Sep 10;5(9):
pubmed: 20844765
Peptides. 2001 Oct;22(10):1629-41
pubmed: 11587791
Biopolymers. 2002;66(4):236-48
pubmed: 12491537
ACS Chem Biol. 2016 Dec 16;11(12):3391-3399
pubmed: 27797468
Annu Rev Biophys Biomol Struct. 1999;28:319-65
pubmed: 10410805
J Antimicrob Chemother. 2001 Jul;48 Suppl 1:5-16
pubmed: 11420333
Antibiotics (Basel). 2019 Oct 24;8(4):
pubmed: 31652990
Clin Infect Dis. 2009 Jan 1;48(1):1-12
pubmed: 19035777
Diabetes Care. 2014;37(3):651-8
pubmed: 24186882
mBio. 2019 Sep 3;10(5):
pubmed: 31481386
ACS Chem Biol. 2010 Oct 15;5(10):905-17
pubmed: 20698568
Chem Rev. 2019 May 8;119(9):6040-6085
pubmed: 30624911
mBio. 2019 Aug 13;10(4):
pubmed: 31409682
Clin Infect Dis. 1998 Aug;27 Suppl 1:S93-9
pubmed: 9710677
Adv Exp Med Biol. 2019;1117:281-298
pubmed: 30980363
Curr Protein Pept Sci. 2004 Oct;5(5):365-71
pubmed: 15544531
Microbiology (Reading). 2000 Oct;146 ( Pt 10):2395-2407
pubmed: 11021916
mSystems. 2020 Dec 1;5(6):
pubmed: 33262240
Microbiol Resour Announc. 2019 Mar 21;8(12):
pubmed: 30938705
Int J Infect Dis. 2018 May;70:10-14
pubmed: 29476898
Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93
pubmed: 26602694
Clin Microbiol Rev. 2019 Jan 16;32(2):
pubmed: 30651226
J Am Chem Soc. 2008 Jul 30;130(30):9849-58
pubmed: 18611015
Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8437-8448
pubmed: 32241895
J Antimicrob Chemother. 2017 Nov 01;72(11):3035-3042
pubmed: 28961916
World J Diabetes. 2011 Feb 15;2(2):24-32
pubmed: 21537457
ACS Infect Dis. 2020 Mar 13;6(3):447-458
pubmed: 31898890
ACS Infect Dis. 2021 Jan 8;7(1):123-140
pubmed: 33269912
J Membr Biol. 2022 Oct;255(4-5):503-511
pubmed: 35435452
Nat Struct Biol. 1996 Oct;3(10):842-8
pubmed: 8836100
Antimicrob Agents Chemother. 2013 Jan;57(1):110-9
pubmed: 23070157
Front Cell Infect Microbiol. 2017 Feb 15;7:39
pubmed: 28261568
Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2319-2326
pubmed: 28912099
J Am Chem Soc. 2009 Jun 10;131(22):7609-17
pubmed: 19445503
Sci Transl Med. 2012 Aug 22;4(148):148ra116
pubmed: 22914622
FASEB J. 2010 Sep;24(9):3232-8
pubmed: 20410445
Front Microbiol. 2020 Jan 23;10:3106
pubmed: 32038549