Male Reproduction and Aging.

Middle Aged Humans Male Aged Testosterone / therapeutic use Aging Hypogonadism / drug therapy Reproduction Hormone Replacement Therapy / adverse effects
Androgen deficiency Late-onset hypogonadism Testosterone replacement therapy

Journal

Endocrinology and metabolism clinics of North America
ISSN: 1558-4410
Titre abrégé: Endocrinol Metab Clin North Am
Pays: United States
ID NLM: 8800104

Informations de publication

Date de publication:
06 2023
Historique:
entrez: 22 3 2023
pubmed: 23 3 2023
medline: 25 3 2023
Statut: ppublish

Résumé

Recent publications of well-conducted population studies have informed us that the syndromic prevalence of age-related low testosterone, also known as late-onset hypogonadism, is quite low. Several well-conducted trials in middle-aged and older men with age-related decline in testosterone levels have revealed that efficacy of testosterone therapy is modest with improvement in sexual function, mood, volumetric bone density, and anemia. Although select older men might benefit from testosterone therapy, its effect on prostate cancer risk and major adverse cardiovascular events remains unclear. The results of the ongoing TRAVERSE trial will likely provide important insights into these risks.

Identifiants

DOI: 10.1016/j.ecl.2022.12.002 PMID: 36948776
pubmed: 36948776
pii: S0889-8529(22)00121-9
doi: 10.1016/j.ecl.2022.12.002
pii:
doi:

Substances chimiques

Testosterone 3XMK78S47O

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

211-228

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Maria Gabriela Figueiredo (MG)

Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Thiago Gagliano-Jucá (T)

Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA; Northwestern Medicine McHenry Hospital, Chicago Medical School, Rosalind Franklin University of Medicine and Science, McHenry, IL, USA.

Shehzad Basaria (S)

Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA. Electronic address: sbasaria@bwh.harvard.edu.

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Male Reproduction and Aging.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Male Reproduction and Aging.
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Sujet âgé › Male Reproduction and Aging.
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Male Reproduction and Aging.
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › Male Reproduction and Aging.
Recherchemedicale.com › Maladies endocriniennes › Troubles gonadiques › Hypogonadisme › Male Reproduction and Aging.
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Male Reproduction and Aging.
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Hormonothérapie substitutive › Male Reproduction and Aging.