Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma.

functional enrichment analysis genotyping immunoproteasome subunits molecular carcinogenesis protein-protein interactions psmb8/psmb9 saudi population statistial analysis taqman genotyping assay urothelial bladder carcinoma

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Mar 2023
Historique:
accepted: 17 03 2023
entrez: 20 3 2023
pubmed: 21 3 2023
medline: 21 3 2023
Statut: epublish

Résumé

The  Samples of genomic DNA were taken from buccal cells of 111 patients with UBC and 78 healthy controls. TaqMan Real-Time PCR was used to determine genotype distributions and allele frequencies for the  The  These results suggest a potential role for 

Sections du résumé

BACKGROUND BACKGROUND
The 
METHODS METHODS
Samples of genomic DNA were taken from buccal cells of 111 patients with UBC and 78 healthy controls. TaqMan Real-Time PCR was used to determine genotype distributions and allele frequencies for the 
RESULTS RESULTS
The 
CONCLUSION CONCLUSIONS
These results suggest a potential role for 

Identifiants

pubmed: 36937130
doi: 10.7759/cureus.36293
pmc: PMC10022703
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e36293

Informations de copyright

Copyright © 2023, Elhawary et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

Sci Rep. 2021 Oct 14;11(1):20492
pubmed: 34650125
Science. 2019 Nov 15;366(6467):818-822
pubmed: 31727826
Chin Med J (Engl). 2016 May 5;129(9):1053-8
pubmed: 27098790
Transl Neurodegener. 2016 Aug 26;5(1):16
pubmed: 27570618
Biosci Rep. 2021 Jan 29;41(1):
pubmed: 33289830
CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29
pubmed: 25559415
Nature. 2020 Feb;578(7793):82-93
pubmed: 32025007
Eur Urol. 2013 Jun;63(6):1049-58
pubmed: 23313034
Front Genet. 2022 Aug 08;13:936305
pubmed: 36003338
Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1164-1173
pubmed: 28721901
Cell. 2018 Aug 9;174(4):1033
pubmed: 30096301
Nat Immunol. 2011 Dec 25;13(2):129-35
pubmed: 22197977
Nature. 2014 Nov 27;515(7528):558-62
pubmed: 25428503
Oncotarget. 2017 Dec 21;9(5):6572-6585
pubmed: 29464093
Front Immunol. 2021 May 31;12:664474
pubmed: 34149699
Hum Genomics. 2018 Apr 10;12(1):18
pubmed: 29631625
Cancers (Basel). 2022 Oct 13;14(20):
pubmed: 36291793
Neurobiol Aging. 2006 Jan;27(1):54-66
pubmed: 16298241
Oncotarget. 2017 Jun 28;8(37):62445-62453
pubmed: 28977958
Stem Cells. 2012 Jul;30(7):1373-84
pubmed: 22532526
Cell. 2010 Aug 20;142(4):613-24
pubmed: 20723761
Front Oncol. 2020 Nov 19;10:553399
pubmed: 33330025
Annu Rev Immunol. 2013;31:443-73
pubmed: 23298205
Cancer Res. 2006 Apr 1;66(7):3754-63
pubmed: 16585202
Tumour Biol. 2017 Mar;39(3):1010428317692248
pubmed: 28345458
Acta Pharm Sin B. 2020 Nov;10(11):2054-2074
pubmed: 33304779
Tumori. 2015 Jan-Feb;101(1):117-22
pubmed: 25702669
Neoplasia. 2004 Nov-Dec;6(6):744-50
pubmed: 15720800
Oncogene. 2016 Jun 2;35(22):2881-92
pubmed: 26411365
J Mol Biol. 2009 Feb 27;386(3):814-27
pubmed: 19162040

Auteurs

Nasser A Elhawary (NA)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Samar N Ekram (SN)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Iman S Abumansour (IS)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Zohor A Azher (ZA)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Imad A AlJahdali (IA)

Community Medicine, Umm Al-Qura University, Mecca, SAU.

Najiah M Alyamani (NM)

Molecular Genetics, University of Jeddah, Jeddah, SAU.

Hind M Naffadi (HM)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Ikhlas A Sindi (IA)

Biology, King Abdulaziz University, Jeddah, SAU.

Abdulaziz Baazeem (A)

General Surgery, Umm Al-Qura University, Mecca, SAU.

Anmar M Nassir (AM)

Surgery, Umm Al-Qura University, Makkah, SAU.

Ahmad H Mufti (AH)

Medical Genetics, Umm Al-Qura University, Mecca, SAU.

Classifications MeSH