Pleiotropic endophenotypic and phenotype effects of GABAergic neurosteroid synthesis deficiency in posttraumatic stress disorder.
Allopregnanolone
Depression
GABA
Neurosteroids
PTSD
Pregnanolone
Journal
Current opinion in endocrine and metabolic research
ISSN: 2451-9650
Titre abrégé: Curr Opin Endocr Metab Res
Pays: England
ID NLM: 101722894
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
ppublish
Résumé
PTSD is associated with deficits in synthesis of progesterone metabolites such as allopregnanolone and pregnanolone that potently facilitate gamma-amino-butyric acid (GABA) effects at GABA
Identifiants
pubmed: 36909842
doi: 10.1016/j.coemr.2022.100359
pmc: PMC10004350
mid: NIHMS1880208
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH122867
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest AMR was a paid consultant to Praxis Precision Medicines, Inc., in 2020. SLP, ON, and KDB declare no potential conflicts of interest. GP is a paid consultant to PureTech Health, Neurotrauma Science, and GABA therapeutics. He has two pending patent applications, one on N-palmitoylethanolamine (PEA) and peroxisome proliferator-activated receptor alpha (PPAR-α) agonists, and one on allopregnanolone analogs in the treatment of neuropsychiatric disorders.
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