Graft Failure after Uterus Transplantation in 16 Recipients: A Review.

graft failure hysterectomy thrombosis uterine factor infertility uterine infection uterus transplantation

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
03 Mar 2023
Historique:
received: 29 01 2023
revised: 26 02 2023
accepted: 02 03 2023
entrez: 11 3 2023
pubmed: 12 3 2023
medline: 12 3 2023
Statut: epublish

Résumé

Uterus transplantation (UTx) is now an alternative to surrogacy and adoption for women with uterine factor infertility to have children; however, there are still unresolved clinical and technical issues. One of these is that the graft failure rate after transplantation is somewhat higher than that of other life-saving organ transplants, which is a critical concern. Herein, we summarize the details of 16 graft failures after UTx with living or deceased donors using the published literature in order to learn from these negative outcomes. To date, the main causes of graft failure are vascular factors (arterial and/or venous thrombosis, atherosclerosis, and poor perfusion). Many recipients with thrombosis develop graft failure within one month of surgery. Therefore, it is necessary to devise a safe and stable surgical technique with higher success rates for further development in the UTx field.

Identifiants

pubmed: 36902818
pii: jcm12052032
doi: 10.3390/jcm12052032
pmc: PMC10003853
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Academic Development Fund (Keio University Academic Development Funds)
ID : N/A

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Auteurs

Iori Kisu (I)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Risa Matsuda (R)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Tetsuro Shiraishi (T)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Ryoma Hayashi (R)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Yusuke Matoba (Y)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Masato Tamate (M)

Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo 060-8543, Japan.

Kouji Banno (K)

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Classifications MeSH