Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer.
AlphaFold
cancer
missense variants
pLDDT score
protein stability
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
09
2022
accepted:
08
02
2023
entrez:
10
3
2023
pubmed:
11
3
2023
medline:
11
3
2023
Statut:
epublish
Résumé
Identifying pathogenic missense variants in hereditary cancer is critical to the efforts of patient surveillance and risk-reduction strategies. For this purpose, many different gene panels consisting of different number and/or set of genes are available and we are particularly interested in a panel of 26 genes with a varying degree of hereditary cancer risk consisting of
Identifiants
pubmed: 36896237
doi: 10.3389/fgene.2023.1052383
pii: 1052383
pmc: PMC9988940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1052383Informations de copyright
Copyright © 2023 Keskin Karakoyun, Yüksel, Amanoglu, Naserikhojasteh, Yeşilyurt, Yakıcıer, Timuçin and Akyerli.
Déclaration de conflit d'intérêts
Authors AY, CY were employed by the company Acibadem Health Group. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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