A non-hallucinogenic LSD analog with therapeutic potential for mood disorders.
5-HT2A
5-HT2B
CP: Molecular biology
CP: Neuroscience
G protein-coupled receptor
depression
hallucinogen
neuroplasticity
psychedelic
serotonin
stress
tolerance
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
28 03 2023
28 03 2023
Historique:
received:
31
10
2022
revised:
30
12
2022
accepted:
16
02
2023
medline:
3
4
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-coupled receptors (GPCRs). 2-Br-LSD shows partial agonism at several aminergic GPCRs, including 5-HT
Identifiants
pubmed: 36884348
pii: S2211-1247(23)00214-0
doi: 10.1016/j.celrep.2023.112203
pmc: PMC10112881
mid: NIHMS1890052
pii:
doi:
Substances chimiques
Lysergic Acid Diethylamide
8NA5SWF92O
Serotonin
333DO1RDJY
Hallucinogens
0
volinanserin
EW71EE171J
Piperidines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
112203Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133421
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM080202
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests A.G. and H.S. are employees of BetterLife Pharma Inc.
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