The emerging role of microtubules in invasion plasticity.
3D migration
amoeboid
cancer
invasion plasticity
mesenchymal
microtubules
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
12
2022
accepted:
31
01
2023
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
The ability of cells to switch between different invasive modes during metastasis, also known as invasion plasticity, is an important characteristic of tumor cells that makes them able to resist treatment targeted to a particular invasion mode. Due to the rapid changes in cell morphology during the transition between mesenchymal and amoeboid invasion, it is evident that this process requires remodeling of the cytoskeleton. Although the role of the actin cytoskeleton in cell invasion and plasticity is already quite well described, the contribution of microtubules is not yet fully clarified. It is not easy to infer whether destabilization of microtubules leads to higher invasiveness or the opposite since the complex microtubular network acts differently in diverse invasive modes. While mesenchymal migration typically requires microtubules at the leading edge of migrating cells to stabilize protrusions and form adhesive structures, amoeboid invasion is possible even in the absence of long, stable microtubules, albeit there are also cases of amoeboid cells where microtubules contribute to effective migration. Moreover, complex crosstalk of microtubules with other cytoskeletal networks participates in invasion regulation. Altogether, microtubules play an important role in tumor cell plasticity and can be therefore targeted to affect not only cell proliferation but also invasive properties of migrating cells.
Identifiants
pubmed: 36860323
doi: 10.3389/fonc.2023.1118171
pmc: PMC9969133
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1118171Informations de copyright
Copyright © 2023 Legátová, Pelantová, Rösel, Brábek and Škarková.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Cell Biol. 1999 Sep 6;146(5):1033-44
pubmed: 10477757
Cancer Cell. 2005 Jan;7(1):51-63
pubmed: 15652749
Cancer Res. 2004 Dec 15;64(24):8924-31
pubmed: 15604254
Dev Cell. 2004 Dec;7(6):871-83
pubmed: 15572129
Br J Clin Pharmacol. 2017 Feb;83(2):255-268
pubmed: 27620987
Mol Biol Cell. 2006 Jun;17(6):2811-23
pubmed: 16554367
Nat Cell Biol. 2005 Jun;7(6):581-90
pubmed: 15895076
Essays Biochem. 2019 Oct 31;63(5):509-520
pubmed: 31358621
J Cell Biol. 2006 Jan 16;172(2):245-57
pubmed: 16401721
J Cell Biol. 2012 Aug 20;198(4):481-9
pubmed: 22908306
Eur J Cell Biol. 2020 May;99(4):151075
pubmed: 32414588
Trends Cell Biol. 2010 Feb;20(2):64-70
pubmed: 19931459
Oncogene. 2000 Jul 27;19(32):3675-83
pubmed: 10951574
Folia Biol (Praha). 2012;58(5):177-84
pubmed: 23249636
Nat Rev Mol Cell Biol. 2009 May;10(5):353-9
pubmed: 19373240
Trends Cancer. 2017 Jun;3(6):391-406
pubmed: 28670628
J Biol Chem. 1996 Aug 23;271(34):20246-9
pubmed: 8702756
Mol Biol Cell. 2008 May;19(5):2147-53
pubmed: 18287519
J Cell Sci. 2009 Apr 15;122(Pt 8):1059-69
pubmed: 19339545
J Cell Biol. 2005 Oct 24;171(2):197-200
pubmed: 16247021
Annu Rev Biomed Eng. 2005;7:105-50
pubmed: 16004568
J Cell Sci. 2001 Aug;114(Pt 15):2879-87
pubmed: 11683421
Mol Cell Biol. 2003 Jan;23(1):216-28
pubmed: 12482975
Mol Biol Cell. 2017 Nov 7;28(23):3240-3251
pubmed: 28855377
J Biol Chem. 2001 Jan 19;276(3):1677-80
pubmed: 11058583
Science. 1996 Jul 12;273(5272):245-8
pubmed: 8662509
Mol Biol Cell. 2009 Sep;20(18):4070-82
pubmed: 19625450
FEBS J. 2016 Aug;283(15):2836-52
pubmed: 27307301
Sci Rep. 2015 Jul 16;5:12136
pubmed: 26179371
J Cell Biol. 2010 May 3;189(3):541-56
pubmed: 20421424
J Cell Biol. 2003 Jun 9;161(5):853-9
pubmed: 12782685
Cell. 1996 Feb 23;84(4):623-31
pubmed: 8598048
Mol Cell Biol. 2014 Jan;34(1):16-29
pubmed: 24144981
J Cell Sci. 2014 Sep 15;127(Pt 18):4009-23
pubmed: 25015295
J Clin Invest. 1999 Oct;104(7):865-74
pubmed: 10510327
Oncogene. 2016 Sep 15;35(37):4846-56
pubmed: 26876215
J Cell Sci. 2005 Jul 1;118(Pt 13):2901-11
pubmed: 15976449
Mol Cell Biol. 2008 Apr;28(7):2314-23
pubmed: 18212043
Cancers (Basel). 2020 Jan 11;12(1):
pubmed: 31940801
Nat Commun. 2015 Nov 09;6:8720
pubmed: 26548801
Sci Rep. 2015 Mar 30;5:9466
pubmed: 25820462
Am J Pathol. 2005 Jun;166(6):1841-50
pubmed: 15920168
Nature. 2019 Apr;568(7753):546-550
pubmed: 30944468
Molecules. 2020 Oct 12;25(20):
pubmed: 33053667
Front Pharmacol. 2019 Apr 16;10:368
pubmed: 31040780
Front Cell Dev Biol. 2022 Jul 15;10:926394
pubmed: 35912094
Breast Cancer Res. 2022 Feb 14;24(1):13
pubmed: 35164808
Mol Biol Cell. 2001 Jul;12(7):2137-45
pubmed: 11452009
Biochim Biophys Acta. 2004 Jul 5;1692(2-3):103-19
pubmed: 15246682
Nature. 2002 Aug 15;418(6899):790-3
pubmed: 12181570
Dev Cell. 2016 Dec 19;39(6):708-723
pubmed: 27939686
Genes Dev. 2004 Apr 15;18(8):862-76
pubmed: 15078817
Nat Cell Biol. 2002 Apr;4(4):294-301
pubmed: 11912491
Future Oncol. 2019 May;15(14):1641-1653
pubmed: 30892083
J Cell Sci. 2017 Jan 1;130(1):39-50
pubmed: 28043967
EMBO Mol Med. 2012 Aug;4(8):743-60
pubmed: 22593025
PLoS One. 2014 Feb 28;9(2):e90371
pubmed: 24587343
J Biol Chem. 1997 Oct 3;272(40):25029-36
pubmed: 9312110
Cell. 2015 Feb 12;160(4):581-582
pubmed: 25679757
Nat Commun. 2021 May 14;12(1):2815
pubmed: 33990566
J Cell Sci. 2008 Apr 1;121(Pt 7):1096-106
pubmed: 18334555
EMBO Mol Med. 2015 Feb 12;7(3):299-314
pubmed: 25678558
Mol Biol Cell. 2022 Jan 1;33(1):ar2
pubmed: 34731043
Curr Opin Cell Biol. 2003 Feb;15(1):23-30
pubmed: 12517700
Nat Commun. 2013;4:1412
pubmed: 23361003
Cells. 2021 Jul 21;10(8):
pubmed: 34440616
J Cell Biol. 2019 Sep 2;218(9):3077-3097
pubmed: 31420453
FASEB J. 2018 Mar;32(3):1207-1221
pubmed: 29097501
Cell. 2001 Aug 24;106(4):489-98
pubmed: 11525734
Mol Cell Biol. 2010 May;30(9):2229-40
pubmed: 20194624
Br J Cancer. 2014 Mar 18;110(6):1497-505
pubmed: 24569463
Curr Biol. 2014 Aug 4;24(15):1778-85
pubmed: 25065758
Cell Commun Signal. 2013 Jul 30;11:51
pubmed: 23899007
J Biol Chem. 2015 Sep 25;290(39):23766-80
pubmed: 26242911
Science. 2000 Oct 13;290(5490):333-7
pubmed: 11030651
J Cell Biol. 2008 Jun 16;181(6):985-98
pubmed: 18541705
Biol Cell. 2018 Mar;110(3):49-64
pubmed: 29388220
Small GTPases. 2014;5:e27958
pubmed: 24607953
Mol Cancer Ther. 2008 May;7(5):1164-75
pubmed: 18483304
R Soc Open Sci. 2016 Sep 28;3(9):160283
pubmed: 27703691
Cancer Sci. 2008 Nov;99(11):2252-9
pubmed: 18795939
J Cell Sci. 2008 Jul 15;121(Pt 14):2406-14
pubmed: 18577576
Circ Res. 2004 Aug 6;95(3):276-83
pubmed: 15217908
J Cell Sci. 2019 Oct 9;132(19):
pubmed: 31597743
Biophys J. 2014 Dec 16;107(12):2860-2871
pubmed: 25517152
Eur J Cell Biol. 2008 Sep;87(8-9):469-77
pubmed: 18436334
Nat Commun. 2021 Jun 18;12(1):3799
pubmed: 34145230
J Cell Biol. 2003 Jan 20;160(2):267-77
pubmed: 12527751
J Biol Chem. 1997 Nov 21;272(47):29579-83
pubmed: 9368021
Science. 1999 Aug 6;285(5429):895-8
pubmed: 10436159
Urol Oncol. 2014 Jan;32(1):47.e21-8
pubmed: 24140250
Dev Biol. 2004 Jan 1;265(1):23-32
pubmed: 14697350
J Cell Biol. 2000 Sep 18;150(6):1299-310
pubmed: 10995436
Nat Rev Drug Discov. 2010 Oct;9(10):790-803
pubmed: 20885410
Trends Cancer. 2019 Dec;5(12):755-756
pubmed: 31813449
J Cell Sci. 2012 May 1;125(Pt 9):2300-14
pubmed: 22344260
J Cell Sci. 2007 Feb 15;120(Pt 4):658-69
pubmed: 17264147
Nat Commun. 2018 Sep 12;9(1):3696
pubmed: 30209389
Cell Motil Cytoskeleton. 2009 Oct;66(10):824-38
pubmed: 19396870
Biochem Biophys Res Commun. 2009 Feb 6;379(2):304-8
pubmed: 19111674
Curr Opin Cell Biol. 2009 Oct;21(5):636-44
pubmed: 19523798
Dev Cell. 2017 Jan 23;40(2):168-184
pubmed: 28041907
Cell. 2015 Feb 12;160(4):673-685
pubmed: 25679761
Mol Cell Biol. 2009 Sep;29(18):5031-45
pubmed: 19596789
Cell Signal. 2012 Apr;24(4):826-34
pubmed: 22182509
Oncotarget. 2019 Jan 4;10(2):161-174
pubmed: 30719211
Curr Opin Cell Biol. 2008 Apr;20(2):235-41
pubmed: 18337078
Mol Biol Cell. 1999 Jan;10(1):105-18
pubmed: 9880330
Curr Opin Cell Biol. 2011 Oct;23(5):579-88
pubmed: 21885270
Mol Cell Biol. 1997 Jun;17(6):3459-67
pubmed: 9154845
J Cell Biol. 2013 Jun 24;201(7):1069-84
pubmed: 23798731
J Cell Sci. 2014 Dec 15;127(Pt 24):5179-88
pubmed: 25344256
Trends Cell Biol. 2007 Mar;17(3):107-17
pubmed: 17275303
J Biol Chem. 2011 Nov 25;286(47):40638-48
pubmed: 21984824
Integr Biol (Camb). 2014 Sep;6(9):885-94
pubmed: 25044255
BMC Cancer. 2012 Oct 12;12:469
pubmed: 23057787
Mol Biol Cell. 1999 Apr;10(4):947-59
pubmed: 10198049
Nature. 2013 Oct 24;502(7472):567-70
pubmed: 24097348
Annu Rev Cell Dev Biol. 2013;29:471-99
pubmed: 23875648
J Cell Biol. 2009 Feb 23;184(4):481-90
pubmed: 19221195
J Cell Biol. 1997 Jun 30;137(7):1555-66
pubmed: 9199170
J Cell Biol. 2010 Jan 11;188(1):11-9
pubmed: 19951899
Mol Biol Cell. 2012 Jul;23(13):2583-92
pubmed: 22593214
Biochem Biophys Res Commun. 2017 Mar 4;484(2):255-261
pubmed: 28115158
Cell Commun Signal. 2010 Sep 07;8:22
pubmed: 20822526
Curr Opin Cell Biol. 1999 Feb;11(1):61-7
pubmed: 10047528
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32379884
Sci Data. 2020 May 27;7(1):160
pubmed: 32461585
Science. 2004 Mar 19;303(5665):1862-6
pubmed: 15031504
Small GTPases. 2014;5:e29019
pubmed: 25036871
Nat Cell Biol. 1999 May;1(1):45-50
pubmed: 10559863
Cell Mol Life Sci. 2010 Jan;67(2):321-33
pubmed: 19915797
Curr Biol. 1996 Oct 1;6(10):1279-89
pubmed: 8939572
Oncogene. 1998 Jan 15;16(2):147-52
pubmed: 9464532
Cancer Res. 2007 May 1;67(9):4227-35
pubmed: 17483334
J Cell Sci. 2000 Dec;113 Pt 23:4165-76
pubmed: 11069762
Clin Transl Oncol. 2015 Jan;17(1):1-10
pubmed: 25073600
J Surg Res. 2018 Apr;224:50-57
pubmed: 29506852
Cell Mol Life Sci. 2010 Jan;67(1):63-71
pubmed: 19707854
Cell. 2002 Jun 28;109(7):873-85
pubmed: 12110184
Mol Biol Cell. 2008 May;19(5):2003-13
pubmed: 18305103
J Cell Sci. 1998 Nov;111 ( Pt 22):3333-46
pubmed: 9788875
Nat Commun. 2015 Jan 22;6:6135
pubmed: 25609142
Nat Cell Biol. 2001 Aug;3(8):723-9
pubmed: 11483957
Cell Metab. 2021 Jul 6;33(7):1342-1357.e10
pubmed: 34102109
Nat Cell Biol. 2003 Aug;5(8):711-9
pubmed: 12844144
Nat Cell Biol. 2001 Jan;3(1):8-14
pubmed: 11146620
Eur J Cell Biol. 2002 Jun;81(6):351-62
pubmed: 12113476
Curr Opin Cell Biol. 2013 Oct;25(5):619-26
pubmed: 23830911
Cell. 2015 Feb 12;160(4):659-672
pubmed: 25679760
J Biol Chem. 2003 Oct 17;278(42):41237-45
pubmed: 12900413
J Cell Biol. 2013 Feb 4;200(3):249-58
pubmed: 23382461
Br J Pharmacol. 2014 Dec;171(24):5507-23
pubmed: 24665826
Nat Cell Biol. 2018 Mar;20(3):252-261
pubmed: 29379139
Oncogene. 2021 Jan;40(3):578-591
pubmed: 33199827
Curr Biol. 2017 Feb 6;27(3):392-400
pubmed: 28089517
Eur J Cell Biol. 2012 Nov-Dec;91(11-12):950-60
pubmed: 22902175
Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C436-47
pubmed: 25500742
J Biol Chem. 1996 Sep 20;271(38):23363-7
pubmed: 8798539
Biophys J. 2010 Sep 22;99(6):1726-33
pubmed: 20858416
Cell Rep. 2018 May 22;23(8):2429-2442
pubmed: 29791853
Cell. 2008 Oct 31;135(3):510-23
pubmed: 18984162
EMBO J. 1996 Jun 17;15(12):2997-3005
pubmed: 8670801
Int Rev Cell Mol Biol. 2020;356:197-256
pubmed: 33066874
Mol Biol Evol. 2008 Dec;25(12):2717-33
pubmed: 18840602
J Cell Biol. 1998 Jul 13;142(1):181-90
pubmed: 9660872
Sci Rep. 2018 Aug 13;8(1):12020
pubmed: 30104699
Oncotarget. 2016 May 3;7(18):25022-49
pubmed: 26872368
Adv Cancer Res. 2016;132:209-64
pubmed: 27613134
J Biol Chem. 2007 Jan 5;282(1):426-35
pubmed: 17085436
J Cell Biol. 2020 Sep 7;219(9):
pubmed: 32497170
PLoS One. 2010 Jan 19;5(1):e8774
pubmed: 20098744