Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.
Blimp-1
FTZ-F1
ecdysone
protein degradation
pupation timing
timer
transcriptional repressor
Journal
Genes to cells : devoted to molecular & cellular mechanisms
ISSN: 1365-2443
Titre abrégé: Genes Cells
Pays: England
ID NLM: 9607379
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
15
02
2023
received:
27
12
2022
accepted:
15
02
2023
medline:
8
5
2023
pubmed:
1
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
The PRDM family transcription repressor Blimp-1 is present in almost all multicellular organisms and plays important roles in various developmental processes. This factor has several conserved motifs among different species, but the function of each motif is unclear. Drosophila Blimp-1 plays an important role in determining pupation timing by acting as an unstable transcriptional repressor of the βftz-f1 gene. Thus, Drosophila provides a good system for analyzing the molecular and biological functions of each region in Blimp-1. Various Blimp-1 mutants carrying deletions at the conserved motifs were induced under the control of the heat shock promoter in prepupae, and the expression patterns of βFTZ-F1 and Blimp-1 and pupation timing were observed. The results showed that the regions with strong and weak repressor functions exist within the proline-rich middle section of the factor and near the N-terminal conserved motif, respectively. Rapid degradation was supported by multiple regions that were mainly located in a large proline-rich region. Results revealed that pupation timing was affected by the repression ability and stability of Blimp-1. This suggests that both the repression function and instability of Blimp-1 are indispensable for the precise determination of pupation timing.
Substances chimiques
Blimp-1 protein, Drosophila
0
DNA-Binding Proteins
0
Drosophila Proteins
0
Repressor Proteins
0
nuclear hormone receptor FTZ-F1, Drosophila
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
338-347Informations de copyright
© 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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