Current Approaches in Computational Psychiatry for the Data-Driven Identification of Brain-Based Subtypes.
Biomarkers
Biotypes
Clinical utility
Neuroimaging
Precision medicine
Reproducibility
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 04 2023
15 04 2023
Historique:
received:
15
08
2022
revised:
15
12
2022
accepted:
19
12
2022
pmc-release:
15
04
2024
pubmed:
26
2
2023
medline:
25
3
2023
entrez:
25
2
2023
Statut:
ppublish
Résumé
The ability of our current psychiatric nosology to accurately delineate clinical populations and inform effective treatment plans has reached a critical point with only moderately successful interventions and high relapse rates. These challenges continue to motivate the search for approaches to better stratify clinical populations into more homogeneous delineations, to better inform diagnosis and disease evaluation, and prescribe and develop more precise treatment plans. The promise of brain-based subtyping based on neuroimaging data is that finding subgroups of individuals with a common biological signature will facilitate the development of biologically grounded, targeted treatments. This review provides a snapshot of the current state of the field in empirical brain-based subtyping studies in child, adolescent, and adult psychiatric populations published between 2019 and March 2022. We found that there is vast methodological exploration and a surprising number of new methods being created for the specific purpose of brain-based subtyping. However, this methodological exploration and advancement is not being met with rigorous validation approaches that assess both reproducibility and clinical utility of the discovered brain-based subtypes. We also found evidence for a collaboration crisis, in which methodological exploration and advancements are not clearly grounded in clinical goals. We propose several steps that we believe are crucial to address these shortcomings in the field. We conclude, and agree with the authors of the reviewed studies, that the discovery of biologically grounded subtypes would be a significant advancement for treatment development in psychiatry.
Identifiants
pubmed: 36841702
pii: S0006-3223(22)01869-8
doi: 10.1016/j.biopsych.2022.12.020
pmc: PMC10038896
mid: NIHMS1861949
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
704-716Subventions
Organisme : NIDA NIH HHS
ID : U01 DA055371
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096773
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH125829
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123716
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA055330
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041148
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH120025
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA048756
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA055330
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA056499
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Informations de copyright
Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Références
Biol Psychiatry. 2016 Oct 1;80(7):552-61
pubmed: 26927419
Netw Neurosci. 2019 Feb 01;3(2):344-362
pubmed: 30793086
Neuroimage Clin. 2019;22:101796
pubmed: 30935858
Brain Connect. 2022 Mar;12(2):193-205
pubmed: 34102874
Med Image Anal. 2022 Jan;75:102304
pubmed: 34818611
Neuroimage Clin. 2020;27:102288
pubmed: 32526684
Schizophr Bull. 2020 Apr 10;46(3):623-632
pubmed: 31901940
Phys Life Rev. 2014 Sep;11(3):400-35
pubmed: 24819881
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Mar;3(3):223-230
pubmed: 29486863
Transl Psychiatry. 2020 Nov 6;10(1):384
pubmed: 33159037
Nat Commun. 2014 Jun 26;5:4212
pubmed: 24967666
Nat Neurosci. 2017 Feb 23;20(3):365-377
pubmed: 28230847
Neuropsychopharmacology. 2018 Mar;43(4):891-899
pubmed: 29154368
Neuron. 2022 May 4;110(9):1446-1449
pubmed: 35512638
J Psychiatr Res. 2021 Sep;141:257-266
pubmed: 34260994
Neuroimage. 2012 Apr 15;60(3):1759-70
pubmed: 22209809
Dev Cogn Neurosci. 2018 Aug;32:4-7
pubmed: 29051027
Clin Psychol Rev. 2021 Jul;87:102033
pubmed: 33962352
Neuron. 2015 Aug 5;87(3):657-70
pubmed: 26212711
Transl Psychiatry. 2020 Oct 26;10(1):359
pubmed: 33106472
J Consult Clin Psychol. 1982 Oct;50(5):727-35
pubmed: 7142547
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
Neuroimage. 2016 Nov 15;142:55-66
pubmed: 27417345
Nature. 2022 Mar;603(7902):654-660
pubmed: 35296861
Trends Cogn Sci. 2019 Jul;23(7):584-601
pubmed: 31153774
Brain Connect. 2019 Nov;9(9):673-691
pubmed: 31631690
BMC Med Res Methodol. 2014 Apr 01;14:45
pubmed: 24690082
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jun;4(6):554-566
pubmed: 31176387
Neuroimage. 2017 Jul 1;154:59-80
pubmed: 28363836
Brain. 2020 Mar 1;143(3):1027-1038
pubmed: 32103250
Mol Autism. 2022 Feb 23;13(1):9
pubmed: 35197121
Neurosci Biobehav Rev. 2019 Sep;104:240-254
pubmed: 31330196
Mol Psychiatry. 2013 Aug;18(8):846-8
pubmed: 23896674
Syst Rev. 2021 Mar 29;10(1):89
pubmed: 33781348
Front Psychiatry. 2021 Oct 22;12:665536
pubmed: 34744805
Clin Kidney J. 2020 Nov 24;14(1):49-58
pubmed: 33564405
Psychopharmacology (Berl). 2021 May;238(5):1231-1239
pubmed: 31134293
Neuroimage. 2017 Jan 15;145(Pt B):346-364
pubmed: 26923371
JAMA Psychiatry. 2022 May 1;79(5):464-474
pubmed: 35262657
Neuroimage. 2019 Jun;193:35-45
pubmed: 30831310
BMC Med. 2013 May 14;11:126
pubmed: 23672542
Neuroimage. 2021 Feb 1;226:117539
pubmed: 33186723
Nat Hum Behav. 2019 Aug;3(8):768-771
pubmed: 31253883
Autism Res. 2022 Jan;15(1):42-55
pubmed: 34704385
J Child Psychol Psychiatry. 2021 Sep;62(9):1140-1149
pubmed: 33786843
Neuroimaging Clin N Am. 2020 Feb;30(1):35-44
pubmed: 31759570
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Neuroimage. 2020 Mar;208:116400
pubmed: 31778819
Psychol Sci. 2020 Jul;31(7):792-806
pubmed: 32489141
Pac Symp Biocomput. 2002;:6-17
pubmed: 11928511
Hum Brain Mapp. 2019 Feb 1;40(2):628-637
pubmed: 30251763
Neural Comput. 2004 Jun;16(6):1299-323
pubmed: 15130251
World Psychiatry. 2022 Feb;21(1):133-145
pubmed: 35015359
Annu Rev Clin Psychol. 2018 May 7;14:91-118
pubmed: 29401044
Front Hum Neurosci. 2021 May 06;15:657857
pubmed: 34025376
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Apr 20;91:113-121
pubmed: 30290208
Biol Psychiatry. 2015 May 1;77(9):775-84
pubmed: 25534755
PLoS Med. 2016 Jun 21;13(6):e1002049
pubmed: 27328301
Schizophr Res. 2019 Dec;214:43-50
pubmed: 29274735
Biol Psychiatry. 2017 Mar 15;81(6):484-494
pubmed: 27667698
Neuron. 2017 Aug 16;95(4):791-807.e7
pubmed: 28757305
Gigascience. 2017 Feb 1;6(2):1-14
pubmed: 28369458
Neuroimage Clin. 2020;28:102514
pubmed: 33396001
Patterns (N Y). 2020 Nov 13;1(8):100129
pubmed: 33294870
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Sep;1(5):433-447
pubmed: 27642641
Brain Connect. 2022 Feb;12(1):61-73
pubmed: 34049447
Transl Psychiatry. 2021 Jan 14;11(1):48
pubmed: 33446647
Mol Psychiatry. 2019 Oct;24(10):1415-1424
pubmed: 31201374