COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality.

Male Humans Aged Brain-Derived Neurotrophic Factor Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Intermediate Filaments Pilot Projects COVID-19 Morbidity
BDNF COVID-19 MMP-2 MMP-9 NFL NGF NeuroCOVID aging

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
17 02 2023
Historique:
received: 26 01 2023
revised: 14 02 2023
accepted: 15 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 3 3 2023
Statut: epublish

Résumé

Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.

Sections du résumé

BACKGROUND AND METHODS
Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals.
RESULTS
We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome.
CONCLUSIONS
Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.

Identifiants

DOI: 10.3390/cells12040655 PMID: 36831321 PMC: PMC9954454
pubmed: 36831321
pii: cells12040655
doi: 10.3390/cells12040655
pmc: PMC9954454
pii:
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0
Matrix Metalloproteinase 9 EC 3.4.24.35
Matrix Metalloproteinase 2 EC 3.4.24.24

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Carla Petrella (C)

Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
ORCID: 0000-0003-0651-1816

Maria Antonella Zingaropoli (MA)

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy.

Flavio Maria Ceci (FM)

Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Patrizia Pasculli (P)

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy.
ORCID: 0000-0002-6678-6865

Tiziana Latronico (T)

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", 70121 Bari, Italy.
ORCID: 0000-0001-6971-5416

Grazia Maria Liuzzi (GM)

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", 70121 Bari, Italy.
ORCID: 0000-0001-5692-9335

Maria Rosa Ciardi (MR)

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy.

Antonio Angeloni (A)

Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Evaristo Ettorre (E)

Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

Michela Menghi (M)

Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Christian Barbato (C)

Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
ORCID: 0000-0003-1737-9064

Giampiero Ferraguti (G)

Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
ORCID: 0000-0001-6129-4071

Antonio Minni (A)

Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
Division of Otolaryngology-Head and Neck Surgery, ASL Rieti-Sapienza University, Ospedale San Camillo de Lellis, Viale Kennedy, 02100 Rieti, Italy.

Marco Fiore (M)

Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.
ORCID: 0000-0001-6806-9715

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