Stress, hypothalamic pituitary adrenal axis activity and autonomic nervous system function in adolescents with insomnia.
Adolescence
Autonomic
CAR
Cortisol
Insomnia
Stress
TSST
Journal
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
ISSN: 1872-7697
Titre abrégé: Int J Psychophysiol
Pays: Netherlands
ID NLM: 8406214
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
18
07
2022
revised:
14
02
2023
accepted:
16
02
2023
pmc-release:
01
05
2024
pubmed:
24
2
2023
medline:
28
3
2023
entrez:
23
2
2023
Statut:
ppublish
Résumé
Abnormal stress responses have been linked to the etiology of insomnia. We investigated the relationship between insomnia, stress, hypothalamic-pituitary-adrenal (HPA) axis activity, and autonomic nervous system (ANS) function in adolescence. Forty-seven post-pubertal adolescents (16-20 years old, 28 female) with (N = 16; insomnia group) and without (N = 31; control group) DSM-5 insomnia symptoms were assessed for stress levels and stress reactivity and underwent a standardized stress protocol (Trier Social Stress Test (TSST)), after an overnight laboratory stay. Cortisol was measured upon awakening and 30-minutes later to calculate the cortisol awakening response (CAR). During the TSST, perceived stress, salivary cortisol (HPA activity), heart rate (HR) and blood pressure (BP) measures were collected. Participants in the insomnia group reported more stress from school performance and work overload, with insomnia girls experiencing more stress from peer pressure and future uncertainty than control girls (p < 0.05). No group differences were detected in the CAR and pre-TSST stress levels. All participants showed significant increases in perceived stress (~19 %), HR (~33 %), systolic (~13 %), and diastolic (~15 %) BP in response to the TSST (p < 0.05). Overall HR stress response did not differ between groups, but was lower in boys with insomnia than in girls with insomnia (p < 0.05). Cortisol stress responses were inconclusive, possibly due to a masking effect of CAR, as the task was performed shortly after awakening and larger CARs were associated with blunted cortisol stress responses. Results mostly show no group difference in physiological stress responses, although some interaction effects suggest a potential sex by insomnia interaction. Larger samples are needed to understand the physiological disturbances of insomnia in adolescence.
Identifiants
pubmed: 36822502
pii: S0167-8760(23)00035-1
doi: 10.1016/j.ijpsycho.2023.02.006
pmc: PMC10041935
mid: NIHMS1880010
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-53Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL139652
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest This study was supported by the National Heart, Lung, and Blood Institute (NHLBI) grant R01HL139652 (MdZ). The content is solely the responsibility of the authors and does not necessarily represent the official views the National Institutes of Health. Authors declared no conflict of interest related to the current work. MdZ and FCB have received research funding unrelated to this work from Noctrix Health, Inc. and Lisa Health Inc. MdZ is a co-founder of Lisa Health Inc. MdZ and FCB have ownership of shares in Lisa Health.
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