Evaluation of the relationship between inflammatory reaction and interleukins in ovine pulmonary adenocarcinomas.
Inflammation
Interleukins
Pulmonary adenomatosis
Sheep
Journal
Veterinary research forum : an international quarterly journal
ISSN: 2008-8140
Titre abrégé: Vet Res Forum
Pays: Iran
ID NLM: 101625812
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
11
2021
accepted:
08
02
2022
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
ppublish
Résumé
In this study, it was aimed to investigate the association between inflammatory reaction of tumoral microenvironments with interleukin responses in ovine pulmonary adenocarcinomas (OPAs). Material of the study consisted of 26 sheep lung tissue samples being brought to the Pathology Department for routine diagnosis. Cases were collected between years 2009 - 2021; pre-diagnosis was based on clinical symptoms, anamnesis and gross lesion of the lungs. These tissues were designated in two groups as control (n = 6) and OPA (n = 20) groups. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Reverse transcription polymerase chain reaction (RT-PCR) was used to confirm Jaagsiekte sheep retrovirus from paraffin-embedded tissues. On gross examination of OPAs, lesions seen were mostly in the caudal lobes of the lung, 1.00 - 2.00 cm in diameter as gray-white consolidated foci and in microscopic observation, tumor cells showed acinar, papillary or mixed growths. No expressions of interleukin (2 and 8) were observed in the control group. All OPAs cases were positive for interleukins (2 and 8) expressions. A total of eight tissue samples were detected as positives through RT-PCR. In conclusion, in this study, it was determined that interleukin-2 and interleukin-8 were produced from tumor microenvironment elements, especially tumor-associated macrophages, and these interleukins showed pro-inflammatory effects. Interleukins and the inflammatory reaction may promote the development of OPA.
Identifiants
pubmed: 36816864
doi: 10.30466/vrf.2022.542311.3279
pmc: PMC9906612
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-6Informations de copyright
© 2023 Urmia University. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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