Toluidine blue for the detection of sentinel lymph nodes in patients with thyroid cancer.
complications
skip metastasis
thyroid cancer
toluidine blue
Journal
Contemporary oncology (Poznan, Poland)
ISSN: 1428-2526
Titre abrégé: Contemp Oncol (Pozn)
Pays: Poland
ID NLM: 101233223
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
12
2022
accepted:
20
12
2022
entrez:
23
2
2023
pubmed:
24
2
2023
medline:
24
2
2023
Statut:
ppublish
Résumé
Thyroid cancer (TC) demonstrates steady growth in incidence worldwide and remains an urgent problem in oncology. The detection of sentinel lymph nodes (SLN) with a selective dye and further histological examination in selecting the proper (personalized) surgical strategy and the volume of surgical intervention for clinically undetermined regional lymph nodes. The purpose of the study is to evaluate the effectiveness and safety of intraoperative detection of SLN with a 1% toluidine blue aqueous solution. The significant tasks are to identify the pattern of TC metastases to cervical lymph nodes, to establish the prevalence of "skip" metastases, to compare the frequency of complications after total thyroidectomy and central neck dissection and lateral neck dissection with total thyroidectomy and central neck dissection, and to determine the feasibility of the application of lateral neck dissections in patients with papillary and follicular TC without metastases to regional lymph nodes (according to physical examination and ultrasound). According to our data the SLN identification rate was 97.6%. Sensitivity, specificity, positive predictive value, negative predictive value, and frequency of false negative and false positive results was 89.2, 94.6, 88.03, 95.16, 10.8, and 5.4%, respectively. The most common metastasis was in the central neck compartment (83.7%). Skip metastases were determined in 4.9% of patients. The low prevalence of "skip" metastases and a significant risk of postoperative complications (wound exudation, lymphorrhagia, inflammation, hypoparathyroidism, paresis of the vocal cords) support the idea that lateral neck dissection is appropriate only in cases of confirmed metastases by physical examination and/or ultrasound at the preoperative stage.
Identifiants
pubmed: 36816393
doi: 10.5114/wo.2022.124585
pii: 50023
pmc: PMC9933357
doi:
Types de publication
Journal Article
Langues
eng
Pagination
259-267Informations de copyright
Copyright © 2022 Termedia.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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