Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study.
Body composition
DEXA
Fat mass
Lean mass
Liver fat
MRI
Prediabetes
Sex differences
Type 2 diabetes
Women
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
27
05
2022
accepted:
22
11
2022
pubmed:
23
2
2023
medline:
28
3
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex. In a population-based cohort study (n=7639; age 40-75 years, 50% women, 25% type 2 diabetes), we estimated the sex-specific associations, and differences therein, of prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes (reference: normal glucose metabolism [NGM]) with dual-energy x-ray absorptiometry (DEXA)- and MRI-derived measures of body composition and with hip circumference. Sex differences were analysed using adjusted regression models with interaction terms of sex-by-diabetes status. Compared with their NGM counterparts, both women and men with prediabetes and type 2 diabetes had more fat and lean mass and a greater hip circumference. The differences in subcutaneous adipose tissue, hip circumference and total and peripheral lean mass between type 2 diabetes and NGM were greater in women than men (women minus men [W-M] mean difference [95% CI]: 15.0 cm This study indicates that there are sex differences in body composition associated with type 2 diabetes. The pathophysiological significance of these sex-associated differences requires further study.
Identifiants
pubmed: 36805778
doi: 10.1007/s00125-023-05880-0
pii: 10.1007/s00125-023-05880-0
pmc: PMC10036428
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
861-872Subventions
Organisme : ZonMw
ID : 849200001
Pays : Netherlands
Organisme : Dutch Ministry of Economic Affairs
ID : 31O.041
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
Références
Heart. 2019 Nov;105(22):1701-1708
pubmed: 31371439
BMJ Open Diabetes Res Care. 2019 Nov 15;7(1):e000787
pubmed: 31798903
Metab Syndr Relat Disord. 2018 Feb;16(1):54-63
pubmed: 29338526
J Diabetes Investig. 2019 Nov;10(6):1471-1479
pubmed: 31074209
Diabetol Metab Syndr. 2016 Feb 12;8:10
pubmed: 26877772
Diabetologia. 2011 Oct;54(10):2506-14
pubmed: 21656330
J Diabetes Complications. 2019 Jun;33(6):451-459
pubmed: 31003924
Metab Syndr Relat Disord. 2011 Feb;9(1):55-62
pubmed: 21091063
Prim Care Diabetes. 2020 Dec;14(6):747-752
pubmed: 32535087
Int J Endocrinol. 2018 Feb 4;2018:1289485
pubmed: 29531527
Obesity (Silver Spring). 2010 Dec;18(12):2354-61
pubmed: 20395951
Int J Obes (Lond). 2010 Jun;34(6):949-59
pubmed: 20065965
N Engl J Med. 2022 Feb 24;386(8):768-779
pubmed: 35196429
Diabetes. 2005 Mar;54(3):672-8
pubmed: 15734842
Adv Exp Med Biol. 2017;1043:9-27
pubmed: 29224088
BMJ. 2011 Mar 11;342:d556
pubmed: 21398359
Gerontology. 2012;58(1):32-40
pubmed: 21358171
J Clin Endocrinol Metab. 2021 Sep 27;106(10):e3881-e3889
pubmed: 34137897
Circ Res. 2016 May 27;118(11):1703-5
pubmed: 27230636
Diabetes Care. 2014;37(3):821-9
pubmed: 24186879
Br J Nutr. 2008 May;99(5):931-40
pubmed: 17977473
Biol Sex Differ. 2018 Jun 27;9(1):28
pubmed: 29950175
Circ Res. 2020 May 22;126(11):1477-1500
pubmed: 32437302
Eur J Epidemiol. 2014 Jun;29(6):439-51
pubmed: 24756374
Int J Obes (Lond). 2010 Dec;34(12):1752-8
pubmed: 20498655
Diabetologia. 2019 May;62(5):789-799
pubmed: 30798333
Exp Gerontol. 2020 Sep;138:111002
pubmed: 32561399
Cardiovasc Diabetol. 2021 May 7;20(1):102
pubmed: 33962619
Am J Clin Nutr. 2003 May;77(5):1192-7
pubmed: 12716671
Diabetes Metab. 2021 Nov;47(6):101219
pubmed: 33418084
J Nutr Health Aging. 2014;18(8):737-43
pubmed: 25286453
Diabetologia. 2005 Feb;48(2):301-8
pubmed: 15660262
Ann Epidemiol. 2011 May;21(5):358-66
pubmed: 21458729
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
Diabetologia. 2009 Oct;52(10):2079-86
pubmed: 19641896
Biogerontology. 2016 Jun;17(3):467-83
pubmed: 26667010
Diabetologia. 2012 May;55(5):1556-7
pubmed: 22349109