Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach.


Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
19 Jan 2023
Historique:
received: 01 10 2022
revised: 31 12 2022
accepted: 09 01 2023
entrez: 11 2 2023
pubmed: 12 2 2023
medline: 15 2 2023
Statut: epublish

Résumé

Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer's disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the

Identifiants

pubmed: 36770702
pii: molecules28031035
doi: 10.3390/molecules28031035
pmc: PMC9919016
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Galantamine 0D3Q044KCA
Acetylcholinesterase EC 3.1.1.7
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Luciane B Silva (LB)

Graduate Program in Medicinal Chemistry and Molecular Modeling, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.
Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

Elenilze F B Ferreira (EFB)

Laboratory of Organic Chemistry and Biochemistry, University of the State of Amapá, Macapá 68900-070, Brazil.
COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad 45550, Pakistan.

José M Espejo-Román (JM)

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.

Glauber V Costa (GV)

Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Laboratory of Biotechnology in Natural Products, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

Josiane V Cruz (JV)

Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

Njogu M Kimani (NM)

Department of Physical Sciences, University of Embu, Embu P.O. Box 6-60100, Kenya.

Josivan S Costa (JS)

Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

José A H M Bittencourt (JAHM)

Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

Jorddy N Cruz (JN)

Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

Joaquín M Campos (JM)

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.

Cleydson B R Santos (CBR)

Graduate Program in Medicinal Chemistry and Molecular Modeling, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.
Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.

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Classifications MeSH