Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives.
mitochondria
mitochondrial diseases
mitochondrial dysfunction
mitochondrial medicine
mitochondrial transplantation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jan 2023
19 Jan 2023
Historique:
received:
22
12
2022
revised:
16
01
2023
accepted:
17
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Mitochondrial diseases (MDs) are inherited genetic conditions characterized by pathogenic mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Current therapies are still far from being fully effective and from covering the broad spectrum of mutations in mtDNA. For example, unlike heteroplasmic conditions, MDs caused by homoplasmic mtDNA mutations do not yet benefit from advances in molecular approaches. An attractive method of providing dysfunctional cells and/or tissues with healthy mitochondria is mitochondrial transplantation. In this review, we discuss what is known about intercellular transfer of mitochondria and the methods used to transfer mitochondria both in vitro and in vivo, and we provide an outlook on future therapeutic applications. Overall, the transfer of healthy mitochondria containing wild-type mtDNA copies could induce a heteroplasmic shift even when homoplasmic mtDNA variants are present, with the aim of attenuating or preventing the progression of pathological clinical phenotypes. In summary, mitochondrial transplantation is a challenging but potentially ground-breaking option for the treatment of various mitochondrial pathologies, although several questions remain to be addressed before its application in mitochondrial medicine.
Identifiants
pubmed: 36768312
pii: ijms24031969
doi: 10.3390/ijms24031969
pmc: PMC9916997
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
ID : RRC
Références
Sci Rep. 2015 Mar 13;5:9073
pubmed: 25766410
Biochim Biophys Acta. 1999 Feb 9;1410(2):103-23
pubmed: 10076021
J Biochem Mol Toxicol. 2021 Nov;35(11):e22898
pubmed: 34435410
Int J Mol Med. 2022 Oct;50(4):
pubmed: 36004457
Front Cell Dev Biol. 2016 Aug 22;4:83
pubmed: 27597941
Nat Commun. 2021 Mar 30;12(1):1971
pubmed: 33785738
Cell Death Dis. 2021 Apr 6;12(4):358
pubmed: 33824273
Sci Rep. 2021 May 19;11(1):10597
pubmed: 34011937
Cells. 2019 Oct 23;8(11):
pubmed: 31652817
Mitochondrion. 2010 Apr;10(3):253-62
pubmed: 20034597
Nat Commun. 2015 Oct 07;6:8472
pubmed: 26442449
Redox Biol. 2015;4:6-13
pubmed: 25479550
J Neurotrauma. 2018 Aug 1;35(15):1800-1818
pubmed: 29648982
Mitochondrion. 2019 Sep;48:16-30
pubmed: 30771504
PLoS Biol. 2022 Mar 23;20(3):e3001576
pubmed: 35320264
Sci Rep. 2018 Feb 20;8(1):3330
pubmed: 29463809
Cell. 2008 Jul 11;134(1):112-23
pubmed: 18614015
Mech Ageing Dev. 2022 Mar;202:111632
pubmed: 35065970
PLoS One. 2018 Sep 18;13(9):e0203956
pubmed: 30226899
Int J Biol Sci. 2019 Oct 15;15(12):2707-2718
pubmed: 31754341
Neuron. 2008 Dec 10;60(5):748-66
pubmed: 19081372
Nature. 2020 Jul;583(7817):631-637
pubmed: 32641830
Pharmaceutics. 2022 Jun 17;14(6):
pubmed: 35745859
J Thorac Cardiovasc Surg. 2021 May;161(5):e337-e347
pubmed: 31866084
Front Pharmacol. 2017 May 09;8:241
pubmed: 28536524
Behav Brain Res. 2019 Jan 1;356:322-331
pubmed: 30213662
Genes Dis. 2019 Aug 31;7(4):578-584
pubmed: 33335957
J Leukoc Biol. 2019 Jul;106(1):171-185
pubmed: 30990921
Int J Mol Sci. 2022 Feb 17;23(4):
pubmed: 35216361
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):817-25
pubmed: 18433711
Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H966-82
pubmed: 23355340
Cell. 2015 Apr 23;161(3):459-469
pubmed: 25910206
Crit Care Med. 2021 Sep 1;49(9):e880-e890
pubmed: 33870913
EMBO J. 2018 May 15;37(10):
pubmed: 29632021
Int J Mol Sci. 2022 May 14;23(10):
pubmed: 35628298
JCI Insight. 2018 Aug 9;3(15):
pubmed: 30089724
Mitochondrion. 2019 Nov;49:269-283
pubmed: 31228566
Cells. 2022 Feb 11;11(4):
pubmed: 35203288
Shock. 2013 Mar;39(3):304-10
pubmed: 23364428
World Neurosurg. 2020 Jun;138:e1-e9
pubmed: 31816451
Stem Cells. 2018 Sep;36(9):1404-1410
pubmed: 29781122
Science. 2014 Jul 25;345(6195):385-6
pubmed: 25061193
Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L78-L88
pubmed: 31693391
EMBO Rep. 2020 Sep 3;21(9):e50964
pubmed: 32852136
Science. 2004 Feb 13;303(5660):1007-10
pubmed: 14963329
Bioeng Transl Med. 2020 Dec 30;6(2):e10209
pubmed: 34027095
J Cell Physiol. 1990 Apr;143(1):160-4
pubmed: 2318903
Theranostics. 2016 May 24;6(8):1244-60
pubmed: 27279915
Sci China Life Sci. 2013 Nov;56(11):994-9
pubmed: 24008389
Cell Cycle. 2018;17(6):712-721
pubmed: 29582715
Nat Rev Mol Cell Biol. 2020 Apr;21(4):204-224
pubmed: 32071438
BMC Med Genomics. 2022 Jan 3;15(1):3
pubmed: 34980117
JACC Basic Transl Sci. 2019 Dec 23;4(8):871-888
pubmed: 31909298
EMBO J. 2014 Oct 1;33(19):2142-56
pubmed: 25107473
Front Neurosci. 2022 Apr 12;16:800883
pubmed: 35495036
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1967-71
pubmed: 109836
Cell Death Dis. 2018 Jan 23;9(2):81
pubmed: 29362447
Transl Neurodegener. 2019 Jun 14;8:17
pubmed: 31210929
Elife. 2021 Jan 13;10:
pubmed: 33438576
Dis Model Mech. 2021 Jun 1;14(6):
pubmed: 34114603
J Thorac Cardiovasc Surg. 2021 Jul;162(1):e111-e121
pubmed: 32919774
Exp Neurol. 2020 Feb;324:113114
pubmed: 31734316
EMBO J. 2014 May 2;33(9):994-1010
pubmed: 24431222
Biochimie. 2022 Apr;195:1-15
pubmed: 35026361
Sci Rep. 2017 Dec 12;7(1):17450
pubmed: 29234096
CNS Neurosci Ther. 2021 Jul;27(7):733-742
pubmed: 33538116
Nat Methods. 2015 May;12(5):439-44
pubmed: 25849636
Nat Commun. 2020 Aug 26;11(1):4261
pubmed: 32848136
Redox Biol. 2018 Sep;18:54-64
pubmed: 29986209
Nat Rev Mol Cell Biol. 2012 Oct;13(10):659-71
pubmed: 22992591
Cell Biosci. 2022 May 19;12(1):66
pubmed: 35590379
Appl Transl Genom. 2016 Oct 15;11:40-47
pubmed: 28018848
J Thorac Cardiovasc Surg. 2020 Aug;160(2):e33-e34
pubmed: 31444067
Pharmaceutics. 2020 Nov 11;12(11):
pubmed: 33187380
J Biol Chem. 1974 Dec 25;249(24):7991-5
pubmed: 4473454
Clin Transl Med. 2016 Mar;5(1):7
pubmed: 26943717
Sci Rep. 2018 Nov 20;8(1):17133
pubmed: 30459350
Neurosci Biobehav Rev. 2023 Jan;144:104961
pubmed: 36395982
Clin Sci (Lond). 2020 Aug 28;134(16):2161-2175
pubmed: 32794577
Schizophr Bull. 2018 Feb 15;44(2):432-442
pubmed: 28586483
Int J Mol Sci. 2021 Apr 30;22(9):
pubmed: 33946468
J Alzheimers Dis. 2019;72(2):587-604
pubmed: 31640104
Stem Cell Res Ther. 2018 Apr 13;9(1):106
pubmed: 29653590
Cell Metab. 2016 May 10;23(5):921-9
pubmed: 27166949
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:240-249
pubmed: 31022424
Mol Neurobiol. 2022 Oct;59(10):6009-6017
pubmed: 35834060
Cell. 1988 Mar 25;52(6):811-9
pubmed: 3349520
Mitochondrion. 2017 May;34:91-100
pubmed: 28242362
NPJ Regen Med. 2020 Nov 23;5(1):22
pubmed: 33298971
Cell. 2006 Jun 30;125(7):1241-52
pubmed: 16814712
Cells. 2015 Dec 31;5(1):
pubmed: 26729171
PLoS One. 2011;6(6):e21283
pubmed: 21738629
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1283-8
pubmed: 16432190
Exp Biol Med (Maywood). 2022 Mar;247(5):416-425
pubmed: 34727745
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Sci Rep. 2020 Aug 31;10(1):14328
pubmed: 32868785
Front Immunol. 2022 Sep 29;13:978571
pubmed: 36248840
Oxid Med Cell Longev. 2021 Nov 20;2021:1006636
pubmed: 34849186
Cell. 2022 May 12;185(10):1764-1776.e12
pubmed: 35472302
Lancet. 2018 Jun 23;391(10139):2560-2574
pubmed: 29903433
J Clin Invest. 2016 Apr 1;126(4):1139-43
pubmed: 27035805
J Neurosci Methods. 2006 Apr 15;152(1-2):48-54
pubmed: 16246427
Mol Biol Cell. 2013 Mar;24(5):659-67
pubmed: 23283981
Int J Mol Sci. 2020 Sep 02;21(17):
pubmed: 32887310
NPJ Genom Med. 2020 Mar 2;5:7
pubmed: 32140258
J Clin Med. 2020 May 12;9(5):
pubmed: 32408624
J Thorac Cardiovasc Surg. 2017 Jul;154(1):286-289
pubmed: 28283239
Mol Hum Reprod. 2015 Jan;21(1):11-22
pubmed: 25425607
Nature. 1988 Feb 25;331(6158):717-9
pubmed: 2830540
J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106801
pubmed: 36257142
Stem Cell Res Ther. 2016 Jul 12;7(1):91
pubmed: 27406134
Mitochondrion. 2017 May;34:127-134
pubmed: 28342934
J Heart Lung Transplant. 2019 Jan;38(1):92-99
pubmed: 30391192
Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H94-H105
pubmed: 18978192
Sci Rep. 2019 Jul 4;9(1):9656
pubmed: 31273236
Methods Cell Biol. 2020;155:3-31
pubmed: 32183964
Methods Mol Biol. 2021;2304:1-35
pubmed: 34028709
Stem Cells Int. 2017;2017:6917941
pubmed: 28659978
Nat Rev Neurol. 2022 Nov;18(11):689-698
pubmed: 36257993
Cells. 2019 Jun 21;8(6):
pubmed: 31234435
J Am Heart Assoc. 2020 Apr 7;9(7):e014501
pubmed: 32200731
Brain. 2004 Oct;127(Pt 10):2153-72
pubmed: 15358637
Life Sci. 2021 Aug 15;279:119669
pubmed: 34081988
Cells. 2020 Jul 02;9(7):
pubmed: 32630649
Front Cardiovasc Med. 2021 Nov 26;8:771298
pubmed: 34901230
Comput Intell Neurosci. 2022 May 31;2022:9325302
pubmed: 35685133
Science. 1989 Oct 27;246(4929):500-3
pubmed: 2814477
Nat Genet. 2018 Dec;50(12):1642-1649
pubmed: 30374071
Curr Biol. 2017 Nov 6;27(21):R1177-R1192
pubmed: 29112874
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9633-8
pubmed: 24979790
Transl Res. 2018 Jun;196:31-41
pubmed: 29548626
PLoS Genet. 2014 Apr 24;10(4):e1004315
pubmed: 24762741
Microvasc Res. 2014 Mar;92:10-8
pubmed: 24486322
Nature. 2016 Jul 27;535(7613):551-5
pubmed: 27466127
J Cell Mol Med. 2020 Sep;24(17):10088-10099
pubmed: 32691975
Swiss Med Wkly. 2016 Nov 10;146:w14374
pubmed: 27878792
Drug Deliv. 2020 Dec;27(1):585-598
pubmed: 32264719
J Thorac Cardiovasc Surg. 2017 Apr;153(4):934-943
pubmed: 27938904
Cells. 2021 Jul 20;10(7):
pubmed: 34359994
Front Cell Dev Biol. 2021 Apr 07;9:653322
pubmed: 33898449
Bioact Mater. 2021 Jan 08;6(7):2058-2069
pubmed: 33511307
J Am Coll Cardiol. 2021 Mar 2;77(8):1073-1088
pubmed: 33632482
Eur J Cardiothorac Surg. 2020 May 1;57(5):836-845
pubmed: 31782771
J Biol Chem. 2008 Feb 8;283(6):3665-3675
pubmed: 18063578
Sci Transl Med. 2022 Dec 21;14(676):eabo3724
pubmed: 36542693
Arch Biochem Biophys. 2019 May 15;666:52-62
pubmed: 30935885
Int J Biol Sci. 2020 Jan 16;16(5):849-858
pubmed: 32071554
Sci Rep. 2021 May 25;11(1):10897
pubmed: 34035362
Cell Metab. 2022 Nov 1;34(11):1620-1653
pubmed: 36323233
Front Neurosci. 2022 Jan 20;15:806260
pubmed: 35126045
Cell Stress. 2019 May 23;3(6):195-207
pubmed: 31225514
BMC Biotechnol. 2019 Jun 28;19(1):42
pubmed: 31253149
PLoS One. 2016 Aug 08;11(8):e0160889
pubmed: 27500955
Biol Reprod. 2007 Sep;77(3):569-76
pubmed: 17554081
Genes Genet Syst. 1998 Feb;73(1):21-7
pubmed: 9546205
Cells. 2022 Aug 01;11(15):
pubmed: 35954208
Front Cell Dev Biol. 2016 Sep 28;4:107
pubmed: 27734015
J Cell Mol Med. 2020 May;24(9):5007-5020
pubmed: 32212298
J Thorac Cardiovasc Surg. 2020 Aug;160(2):e15-e29
pubmed: 31564546
Medicine (Baltimore). 1998 Jan;77(1):59-72
pubmed: 9465864
Front Immunol. 2018 Jan 25;9:43
pubmed: 29422895
PLoS Biol. 2021 Apr 7;19(4):e3001166
pubmed: 33826607
Rev Peru Med Exp Salud Publica. 2021 Apr-Jun;38(2):345-351
pubmed: 34468586
Transl Res. 2016 Apr;170:40-56.e3
pubmed: 26730494
Comput Struct Biotechnol J. 2021 Jun 04;19:3319-3329
pubmed: 34188780
Nat Rev Genet. 2021 Aug;22(8):477-478
pubmed: 34031572
Cell Transplant. 2016;25(5):913-27
pubmed: 26555763
Stroke. 2020 Oct;51(10):3142-3146
pubmed: 32819193
Nat Med. 2012 Apr 15;18(5):759-65
pubmed: 22504485
J Thorac Cardiovasc Surg. 2022 May;163(5):e361-e373
pubmed: 32948302
Neurosignals. 2013;21(3-4):160-73
pubmed: 23006856
Ann Thorac Surg. 2020 Mar;109(3):711-719
pubmed: 31421103
Stem Cells Int. 2017;2017:7610414
pubmed: 28751917
Transgenic Res. 1997 Nov;6(6):379-83
pubmed: 9423287
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
Nat Rev Dis Primers. 2016 Oct 20;2:16080
pubmed: 27775730
Fluids Barriers CNS. 2020 Nov 18;17(1):69
pubmed: 33208141
Cell Death Differ. 2007 Mar;14(3):616-24
pubmed: 16977331
Science. 1988 Dec 9;242(4884):1427-30
pubmed: 3201231
ACS Nano. 2023 Jan 10;:
pubmed: 36625783
Am J Transplant. 2019 Jul;19(7):1917-1929
pubmed: 30761731
Mol Genet Metab. 2017 Nov;122(3):1-9
pubmed: 28943110
Mitochondrion. 2018 Jul;41:37-44
pubmed: 29221810
Genome Biol Evol. 2021 May 7;13(5):
pubmed: 33739376
Nature. 1982 Feb 18;295(5850):605-7
pubmed: 7057918
J Gastroenterol Hepatol. 2020 Dec;35(12):2241-2247
pubmed: 32386240
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165686
pubmed: 31953215
Mol Neurobiol. 2020 Sep;57(9):3875-3890
pubmed: 32613465
Brain Res Bull. 2020 Dec;165:70-80
pubmed: 33010349
Sci Rep. 2017 Sep 6;7(1):10710
pubmed: 28878349
Front Oncol. 2021 May 10;11:672781
pubmed: 34041035