Mechanistic basis of staphylococcal interspecies competition for skin colonization.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
27 Jan 2023
Historique:
pubmed: 8 2 2023
medline: 8 2 2023
entrez: 7 2 2023
Statut: epublish

Résumé

Staphylococci, whether beneficial commensals or pathogens, often colonize human skin, potentially leading to competition for the same niche. In this multidisciplinary study we investigate the structure, binding specificity, and mechanism of adhesion of the Aap lectin domain required for

Identifiants

pubmed: 36747832
doi: 10.1101/2023.01.26.525635
pmc: PMC9900903
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI139479
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153185
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI162964
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM094363
Pays : United States

Déclaration de conflit d'intérêts

Competing interests A.B.H. serves as a Scientific Advisory Board member for Hoth Therapeutics, Inc., holds equity in Hoth Therapeutics and Chelexa BioSciences, LLC, and was a co-inventor on seven patents broadly related to the subject matter of this work.

Auteurs

Joseph J Maciag (JJ)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Constance Chantraine (C)

Louvain Institute of Biomolecular Science and Technology, UCLouvain, Louvain-la-Neuve, Belgium.

Krista B Mills (KB)

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.

Rahul Yadav (R)

Department of Chemistry, Mississippi State University, Mississippi State, MS.

Alexander E Yarawsky (AE)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Catherine T Chaton (CT)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Divya Vinod (D)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Medical Sciences Undergraduate Program, University of Cincinnati, Cincinnati, OH.

Nicholas C Fitzkee (NC)

Department of Chemistry, Mississippi State University, Mississippi State, MS.

Marion Mathelié-Guinlet (M)

Institut de Chimie et Biologie des Membranes et des Nano-Objets, CNRS UMR 5248, University of Bordeaux, Pessac, France.

Yves F Dufrêne (YF)

Louvain Institute of Biomolecular Science and Technology, UCLouvain, Louvain-la-Neuve, Belgium.

Paul D Fey (PD)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE.

Alexander R Horswill (AR)

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.

Andrew B Herr (AB)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

Classifications MeSH