Clinical significance and pitfalls of human chorionic gonadotropin-related tumor markers for intracranial germinomas.
Germinoma
Intact hCG
Total hCG
Tumor marker
hCGβ
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
ISSN: 1433-0350
Titre abrégé: Childs Nerv Syst
Pays: Germany
ID NLM: 8503227
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
08
11
2022
accepted:
22
01
2023
medline:
8
5
2023
pubmed:
7
2
2023
entrez:
6
2
2023
Statut:
ppublish
Résumé
Measuring serum and cerebrospinal fluid human chorionic gonadotropin (hCG) is essential for the diagnosis of intracranial germ cell tumors. There are three types of hCG-related markers in clinical use: hCGβ, intact hCG, and total hCG. The best marker for the diagnosis of intracranial germ cell tumors, especially germinoma, is currently unknown. This study aimed to evaluate the usefulness of these hCG-related markers. We investigated 19 serum samples obtained from 6 patients with histologically diagnosed germinoma treated in our institute. Serum hCGβ, intact hCG, and total hCG values were measured before, during, and after treatment. Samples with hCG values above the lower limits were considered positive. The positivity rates of serum hCGβ, intact hCG, and total hCG were 6% (1/17), 47% (7/15), and 42% (8/19), respectively, with the latter two having significantly higher positivity rates than hCGβ (p = 0.041). Both intact and total hCGs showed similar values. The median values of hCGβ, intact hCG, and total hCG before treatment were 0.1 ng/mL, 4.6 mIU/mL, and 4.5 mIU/mL, respectively. Serum intact and total hCGs have higher detection rates than hCGβ in patients with germinoma using available commercial measurement tools.
Identifiants
pubmed: 36745216
doi: 10.1007/s00381-023-05856-w
pii: 10.1007/s00381-023-05856-w
doi:
Substances chimiques
Biomarkers, Tumor
0
Chorionic Gonadotropin
0
Chorionic Gonadotropin, beta Subunit, Human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
901-907Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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