Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax.
BCL-2 family
apoptosis
bax
conformationnal changes
mitochondria
phosphorylation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
10
2022
accepted:
15
12
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that,
Identifiants
pubmed: 36741728
doi: 10.3389/fonc.2022.1068994
pmc: PMC9892840
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1068994Informations de copyright
Copyright © 2023 Simonyan, Gonin, Hanks, Friedlein, Dutrec, Arokium, Rouchidane Eyitayo, Doudy, Chaignepain, Manon and Dejean.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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