Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei.
auditory organ
autophagy
exocytosis
immunofluorescence
vestibular organ
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
01 Mar 2023
01 Mar 2023
Historique:
pubmed:
26
1
2023
medline:
4
3
2023
entrez:
25
1
2023
Statut:
ppublish
Résumé
Prosaposin is a precursor of lysosomal hydrolases activator proteins, saposins, and also acts as a secretory protein that is not processed into saposins. Prosaposin elicits neurotrophic function via G protein-coupled receptor (GPR) 37, and prosaposin deficiency causes abnormal vestibuloauditory end-organ development. In this study, immunohistochemistry was used to examine prosaposin and GPR37 expression patterns in the mouse cochlear and vestibular nuclei. Prosaposin immunoreactivity was observed in neurons and glial cells in both nuclei. GPR37 immunoreactivity was observed in only some neurons, and its immunoreactivity in the vestibular nucleus was weaker than that in the cochlear nucleus. This study suggests a possibility that prosaposin deficiency affects not only the end-organs but also the first center of the vestibuloauditory system.
Identifiants
pubmed: 36696997
doi: 10.1292/jvms.22-0552
pmc: PMC10076190
doi:
Substances chimiques
Gpr37 protein, mouse
0
Receptors, G-Protein-Coupled
0
Saposins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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