Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 01 2023
13 01 2023
Historique:
received:
01
01
2022
accepted:
03
01
2023
entrez:
13
1
2023
pubmed:
14
1
2023
medline:
18
1
2023
Statut:
epublish
Résumé
Immune system molecules are expressed by neurons, yet their functions are often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR subunits and, in turn, increases synaptic activity and CREB-mediated transcription. We demonstrate that increased IL-13 is a hallmark of traumatic brain injury (TBI) in male mice as well as in two distinct cohorts of human patients. We also provide evidence that IL-13 upregulation protects neurons from excitotoxic death. We show IL-13 upregulation occurring in several cohorts of human brain samples and in cerebrospinal fluid (CSF). Thus, IL-13 is a physiological modulator of synaptic physiology of neuronal origin, with implications for the establishment of synaptic plasticity and the survival of neurons under injury conditions. Furthermore, we suggest that the neuroprotection afforded through the upregulation of IL-13 represents an entry point for interventions in the pathophysiology of TBI.
Identifiants
pubmed: 36639371
doi: 10.1038/s41467-023-35806-8
pii: 10.1038/s41467-023-35806-8
pmc: PMC9839781
doi:
Substances chimiques
Interleukin-13
0
IL13 protein, human
0
Banques de données
figshare
['10.6084/m9.figshare.21758552']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
200Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL141159
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Neuron. 2015 Mar 04;85(5):942-58
pubmed: 25741722
J Neuroinflammation. 2018 Jun 4;15(1):174
pubmed: 29866203
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):
pubmed: 33443211
Cell Rep. 2020 Aug 4;32(5):107960
pubmed: 32755572
J Neuroinflammation. 2017 Apr 21;14(1):88
pubmed: 28427412
ACS Chem Neurosci. 2020 Dec 16;11(24):4231-4239
pubmed: 33170612
Neuron. 2001 Aug 2;31(2):247-60
pubmed: 11502256
J Mol Diagn. 2012 Jan;14(1):22-9
pubmed: 22166544
Neuron. 1996 Jun;16(6):1179-88
pubmed: 8663994
Nat Neurosci. 2002 May;5(5):405-14
pubmed: 11953750
J Neurotrauma. 2018 Nov 15;35(22):2718-2735
pubmed: 29774782
Methods. 2017 Feb 15;115:80-90
pubmed: 27713081
Nat Rev Neurosci. 2013 Sep;14(9):593-608
pubmed: 23942469
Neurotherapeutics. 2019 Oct;16(4):1304-1319
pubmed: 31372938
J Biol Chem. 2015 Sep 18;290(38):23039-49
pubmed: 26231212
Nat Neurosci. 2003 Feb;6(2):136-43
pubmed: 12536214
PLoS Biol. 2019 Dec 19;17(12):e3000553
pubmed: 31856161
Immunol Res. 2011 May;50(1):87-96
pubmed: 21442426
Acta Neuropathol. 2019 May;137(5):731-755
pubmed: 30535946
Neuron. 2009 Oct 15;64(1):93-109
pubmed: 19840552
Science. 2017 Apr 7;356(6333):
pubmed: 28385956
Cell. 2020 Jul 23;182(2):388-403.e15
pubmed: 32615087
J Neurotrauma. 2014 Apr 1;31(7):618-29
pubmed: 24279428
Front Pharmacol. 2016 Sep 27;7:342
pubmed: 27729864
Immunity. 1996 Mar;4(3):313-9
pubmed: 8624821
Neuroscience. 2017 Feb 20;343:106-114
pubmed: 27916728
Nat Med. 2006 Jan;12(1):99-106
pubmed: 16327802
Nature. 2006 Apr 20;440(7087):1054-9
pubmed: 16547515
Science. 2020 Oct 9;370(6513):
pubmed: 33033186
J Exp Med. 2017 Mar 6;214(3):569-578
pubmed: 28209726
Eur J Histochem. 2018 Dec 20;62(4):
pubmed: 30572697
Science. 1998 Dec 18;282(5397):2258-61
pubmed: 9856949
Int J Mol Sci. 2021 Apr 26;22(9):
pubmed: 33925953
Nat Neurosci. 2001 Aug;4(8):794-802
pubmed: 11477425
Int Immunopharmacol. 2017 Oct;51:66-75
pubmed: 28806641
Nat Protoc. 2009;4(9):1328-37
pubmed: 19713954
Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H24-H34
pubmed: 30339498
Science. 2011 Sep 2;333(6047):1292-6
pubmed: 21885782
Front Immunol. 2018 Jun 07;9:888
pubmed: 29930549
Stroke. 2019 Aug;50(8):2207-2215
pubmed: 31272316
Cytokine. 2018 Mar;103:114-120
pubmed: 28969943
Brain Behav Immun. 2012 Aug;26(6):959-71
pubmed: 22609298
Clin Cancer Res. 1999 May;5(5):985-90
pubmed: 10353730
Nat Commun. 2017 Oct 24;8(1):1103
pubmed: 29062097
Immunology. 2019 Dec;158(4):281-286
pubmed: 31509236
J Immunol. 2017 Apr 1;198(7):2681-2688
pubmed: 28202615
Nat Neurosci. 2011 Jun;14(6):727-35
pubmed: 21516102
N Engl J Med. 2011 Sep 22;365(12):1088-98
pubmed: 21812663
J Neurosci. 2009 Mar 18;29(11):3442-52
pubmed: 19295150
J Biol Chem. 2015 Nov 27;290(48):28596-603
pubmed: 26453298
EMBO J. 2018 Aug 1;37(15):
pubmed: 29950309
N Engl J Med. 2018 Jun 28;378(26):2475-2485
pubmed: 29782224
J Immunol. 2020 Mar 15;204(6):1486-1498
pubmed: 32034062
J Cereb Blood Flow Metab. 2018 Nov;38(11):1924-1939
pubmed: 29972341
Glia. 2002 Jun;38(4):273-80
pubmed: 12007140
J Immunol. 2012 Dec 15;189(12):5498-502
pubmed: 23169588
EMBO J. 2021 Mar 1;40(5):e104267
pubmed: 33491217
Clin Exp Immunol. 2019 Sep;197(3):294-307
pubmed: 31125426
Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):319-327
pubmed: 31157635
Glia. 2004 Apr 15;46(2):142-52
pubmed: 15042582
Mol Neurobiol. 2021 Jun;58(6):2803-2811
pubmed: 33501626
Neuropharmacology. 2015 Sep;96(Pt A):42-54
pubmed: 25445486
Brain Behav Immun. 2019 Oct;81:228-246
pubmed: 31207335
Neuron. 2013 Oct 2;80(1):80-96
pubmed: 24094105
Eur J Immunol. 2019 Sep;49(9):1421-1432
pubmed: 31144294
Immunity. 1998 Sep;9(3):423-32
pubmed: 9768762
Pharmacol Ther. 2000 Nov;88(2):143-51
pubmed: 11150594
Cell Rep. 2020 Mar 24;30(12):4303-4316.e6
pubmed: 32209486
Neuron. 2009 Nov 25;64(4):463-70
pubmed: 19945389
Front Cell Neurosci. 2016 Jan 12;9:496
pubmed: 26834559
J Neurosci. 2001 May 1;21(9):3063-72
pubmed: 11312291
J Allergy Clin Immunol. 2003 Apr;111(4):677-90; quiz 691
pubmed: 12704343
Cereb Cortex. 2019 Jun 1;29(6):2701-2715
pubmed: 29982364