Relevance of Human Aldoketoreductases and Microbial

Male Humans Dihydrotestosterone / metabolism Glucuronidase Testosterone / metabolism Liver / metabolism Glucuronosyltransferase / genetics

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
04 2023
Historique:
received: 04 06 2022
accepted: 06 12 2022
pmc-release: 01 04 2024
pubmed: 10 1 2023
medline: 28 3 2023
entrez: 9 1 2023
Statut: ppublish

Résumé

Testosterone exhibits high variability in pharmacokinetics and glucuronidation after oral administration. Although testosterone metabolism has been studied for decades, the impact of UGT2B17 gene deletion and the role of gut bacterial

Identifiants

DOI: 10.1124/dmd.122.000975 PMID: 36623880 PMC: PMC10043941
pubmed: 36623880
pii: dmd.122.000975
doi: 10.1124/dmd.122.000975
pmc: PMC10043941
doi:

Substances chimiques

Dihydrotestosterone 08J2K08A3Y
Glucuronidase EC 3.2.1.31
Testosterone 3XMK78S47O
Glucuronosyltransferase EC 2.4.1.17

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

427-435

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081299
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135218
Pays : United States

Informations de copyright

Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.

Références

Br J Clin Pharmacol. 2012 Jul;74(1):3-15
pubmed: 22506612
Nucleic Acids Res. 2015 Jan;43(Database issue):D447-52
pubmed: 25352553
Steroids. 2009 Mar;74(3):365-8
pubmed: 19056415
J Biol Chem. 2019 Dec 6;294(49):18586-18599
pubmed: 31636122
Mol Pharmacol. 2020 Sep;98(3):234-242
pubmed: 32587096
J Steroid Biochem Mol Biol. 2019 Jul;191:105350
pubmed: 30959153
J Clin Endocrinol Metab. 2009 Mar;94(3):1005-11
pubmed: 19088161
Cancer Detect Prev. 2007;31(4):310-5
pubmed: 17935910
Osteoporos Int. 2011 Jun;22(6):1981-6
pubmed: 20878390
J Biol Chem. 2010 Aug 6;285(32):24529-37
pubmed: 20522910
Biochem Pharmacol. 2018 Oct;156:32-42
pubmed: 30086285
Steroids. 2011 Apr;76(5):484-90
pubmed: 21255593
Structure. 2017 Jul 5;25(7):967-977.e5
pubmed: 28578872
Am J Hum Genet. 2008 Sep;83(3):337-46
pubmed: 18760392
J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010
pubmed: 16720669
J Clin Endocrinol Metab. 2015 Sep;100(9):3280-7
pubmed: 26120790
Pharmacogenet Genomics. 2015 May;25(5):263-9
pubmed: 25794161
Drug Metab Rev. 2008;40(4):553-624
pubmed: 18949601
Carcinogenesis. 2010 Sep;31(9):1620-6
pubmed: 20554747
Hosp Pharm. 2016 Oct;51(9):712-720
pubmed: 27803500
Blood. 2013 Feb 14;121(7):1175-83
pubmed: 23169782
J Steroid Biochem Mol Biol. 2015 Jan;145:187-92
pubmed: 24861263
J Clin Endocrinol Metab. 2008 Jul;93(7):2500-6
pubmed: 18334593
Clin Transl Sci. 2018 Sep;11(5):513-522
pubmed: 29877607
Drug Metab Dispos. 2018 Jun;46(6):888-896
pubmed: 29602798
Clin Lab. 2015;61(12):1905-10
pubmed: 26882814
ISRN Oncol. 2013 Sep 09;2013:465916
pubmed: 24106614
Ann N Y Acad Sci. 2009 Feb;1155:33-42
pubmed: 19250190
Am J Hum Genet. 2008 Dec;83(6):663-74
pubmed: 18992858
Metabolism. 2019 Oct;99:67-80
pubmed: 31330134
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59
pubmed: 20525905
J Clin Endocrinol Metab. 2006 Feb;91(2):687-93
pubmed: 16332934
Endocr Rev. 2019 Apr 1;40(2):447-475
pubmed: 30137266
Am J Health Syst Pharm. 2018 Mar 15;75(6):351-358
pubmed: 29367424
Drug Test Anal. 2015 Nov-Dec;7(11-12):1063-70
pubmed: 26198073
J Clin Endocrinol Metab. 2005 May;90(5):2610-7
pubmed: 15713724
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
Drug Metab Dispos. 2021 Jul;49(7):592-600
pubmed: 33952609
Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1182-E1192
pubmed: 31689143
World J Diabetes. 2020 Mar 15;11(3):66-77
pubmed: 32180895
J Sex Med. 2005 Mar;2(2):213-26
pubmed: 16422889
Steroids. 2014 Jan;79:49-63
pubmed: 24189185

Auteurs

Abdul Basit (A)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

John K Amory (JK)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

Vijaya Saradhi Mettu (VS)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

Cindy Yanfei Li (CY)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

Scott Heyward (S)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).
ORCID: 0000-0001-7805-3522

Parth B Jariwala (PB)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

Matthew R Redinbo (MR)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.).

Bhagwat Prasad (B)

Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (A.B., V.S.M., B.P.); Departments of Medicine (J.K.A.) and Pharmaceutics (C.Y.L.), University of Washington, Seattle, Washington; BioIVT Inc., Baltimore, Maryland (S.H.); and Departments of Chemistry, Biochemistry, and Microbiology and the Integrated Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.B.J., M.R.R.) bhagwat.prasad@wsu.edu.
ORCID: 0000-0002-9090-0912

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relevance of Human Aldoketoreductases and Microbial
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › 5alpha-Dihydrotestostérone › Relevance of Human Aldoketoreductases and Microbial
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucuronidase › Relevance of Human Aldoketoreductases and Microbial
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Relevance of Human Aldoketoreductases and Microbial
Recherchemedicale.com › Système digestif › Foie › Relevance of Human Aldoketoreductases and Microbial
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Relevance of Human Aldoketoreductases and Microbial