Antioxidant, Anti-Diabetic, Anti-Obesity, and Antihypertensive Properties of Protein Hydrolysate and Peptide Fractions from Black Sesame Cake.
enzymatic hydrolysis
in vitro study
membrane filtration
peptide
sesame
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
26 Dec 2022
26 Dec 2022
Historique:
received:
13
12
2022
revised:
22
12
2022
accepted:
22
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
A low-value by-product of cold-pressed sesame oil is defatted black sesame cake (DBSC). The remaining protein and essential amino acids may be utilized as a renewable biological source to produce bioactive products. The bioactivities of the protein hydrolysate from black sesame cake and its peptide fractions were examined in this study for in vitro antioxidant activity and inhibition of DPP-IV, ACE, α-amylase, α-glucosidase, and pancreatic lipase. By using Flavourzyme to hydrolyze DBSC, followed by ultrafiltration, fractions with peptide sizes of <3, 3−10, and >10 kDa were obtained. According to the findings, the products of DBSC could neutralize free radicals and prevent ferric ion redox reactions. The highest inhibitory effects were shown with low Mw peptides (<3 kDa) against ACE, DPP-IV, α-amylase, and α-glucosidase. DBSC has demonstrated potential as a nutraceutical or functional ingredient for preventing and treating disorders associated with free radicals, such as diabetes, hypertension, and hyperglycemia.
Identifiants
pubmed: 36615405
pii: molecules28010211
doi: 10.3390/molecules28010211
pmc: PMC9821986
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Antioxidants
0
Protein Hydrolysates
0
alpha-Glucosidases
EC 3.2.1.20
Peptides
0
alpha-Amylases
EC 3.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Thailand Research Fund
ID : 71712
Références
Carbohydr Res. 2004 Feb 25;339(3):715-7
pubmed: 15013410
Foods. 2021 Sep 06;10(9):
pubmed: 34574218
Bioresour Technol. 2010 Apr;101(7):2084-9
pubmed: 20015640
J Agric Food Chem. 2016 Feb 3;64(4):831-9
pubmed: 26758401
Pharmacogn Rev. 2014 Jul;8(16):147-55
pubmed: 25125886
Food Sci Nutr. 2018 Jul 27;6(6):1715-1723
pubmed: 30258616
Int J Clin Pract. 2006 Nov;60(11):1454-70
pubmed: 17073841
Nat Prod Commun. 2011 Nov;6(11):1683-8
pubmed: 22224289
Molecules. 2016 Jan 12;21(1):72
pubmed: 26771594
Molecules. 2021 Dec 08;26(24):
pubmed: 34946514
Mar Drugs. 2017 Feb 16;15(2):
pubmed: 28212329
JAMA. 2019 Oct 1;322(13):1312
pubmed: 31573630
Arch Pharm Res. 2008 May;31(5):666-70
pubmed: 18481026
J Lipid Res. 2005 Jul;46(7):1512-6
pubmed: 15863836
Food Chem. 2019 Dec 15;301:125222
pubmed: 31382108
Nutrients. 2018 Nov 12;10(11):
pubmed: 30424533
J Food Biochem. 2021 Jan;45(1):e13587
pubmed: 33346921
Mar Drugs. 2019 Jan 02;17(1):
pubmed: 30609694
J Agric Food Chem. 2015 Jun 17;63(23):5682-93
pubmed: 25996918
Crit Rev Food Sci Nutr. 2018;58(13):2273-2284
pubmed: 28604060
Biosci Biotechnol Biochem. 2006 May;70(5):1118-26
pubmed: 16717411
J Agric Food Chem. 2010 Jan 13;58(1):587-93
pubmed: 19928919
Adv Food Nutr Res. 2017;81:109-159
pubmed: 28317603
Food Chem. 2013 Nov 1;141(1):153-9
pubmed: 23768341
Biomolecules. 2021 Apr 23;11(5):
pubmed: 33922830