Emotion regulation in young adults with family history of harmful alcohol use: A fMRI study.
Emotion regulation
FMRI
Family history of harmful alcohol use
Substance use risk
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
received:
18
07
2022
revised:
31
10
2022
accepted:
14
12
2022
pmc-release:
01
02
2024
pubmed:
8
1
2023
medline:
21
1
2023
entrez:
7
1
2023
Statut:
ppublish
Résumé
Alcohol use disorder is associated with difficulties in emotion regulation and cognitive reappraisal. Family history of harmful alcohol use increases risk of substance use disorders, but no studies have examined whether family history is associated with altered neural activation during cognitive reappraisal relative to passive viewing of negative images in a sample of young adults without current substance use disorders. Participants (N = 75 with positive [n = 31] or negative [n = 44] family histories of harmful alcohol use) completed the emotion regulation task during an MRI scan, and the Emotion Regulation Questionnaire to assess use of emotion regulation and suppression strategies. Whole-brain analyses and amygdala region of interest analyses using linear mixed-effects models assessed family history group and cue effects on neural activation during the task. The groups did not differ on trait reappraisal, suppression, or negative emotion following reappraisal. In general, group effects in whole-brain and amygdala activation during the cognitive reappraisal contrast indicated small effect sizes (2.2% of voxels had d>0.20) that were not significantly different. Participants with positive family histories engaged the right middle and superior frontal gyri to a greater extent than participants with negative family histories during the decrease-negative cue (t = 4.14, p = .001). For at-risk young adults without current harmful substance use, family history of harmful alcohol use does not appear to be associated with disrupted emotion regulation when instructed to apply cognitive reappraisal. Reappraisal may be a feasible therapeutic target for those who develop a substance use disorder with associated emotion dysregulation.
Sections du résumé
BACKGROUND
Alcohol use disorder is associated with difficulties in emotion regulation and cognitive reappraisal. Family history of harmful alcohol use increases risk of substance use disorders, but no studies have examined whether family history is associated with altered neural activation during cognitive reappraisal relative to passive viewing of negative images in a sample of young adults without current substance use disorders.
METHODS
Participants (N = 75 with positive [n = 31] or negative [n = 44] family histories of harmful alcohol use) completed the emotion regulation task during an MRI scan, and the Emotion Regulation Questionnaire to assess use of emotion regulation and suppression strategies. Whole-brain analyses and amygdala region of interest analyses using linear mixed-effects models assessed family history group and cue effects on neural activation during the task.
RESULTS
The groups did not differ on trait reappraisal, suppression, or negative emotion following reappraisal. In general, group effects in whole-brain and amygdala activation during the cognitive reappraisal contrast indicated small effect sizes (2.2% of voxels had d>0.20) that were not significantly different. Participants with positive family histories engaged the right middle and superior frontal gyri to a greater extent than participants with negative family histories during the decrease-negative cue (t = 4.14, p = .001).
CONCLUSIONS
For at-risk young adults without current harmful substance use, family history of harmful alcohol use does not appear to be associated with disrupted emotion regulation when instructed to apply cognitive reappraisal. Reappraisal may be a feasible therapeutic target for those who develop a substance use disorder with associated emotion dysregulation.
Identifiants
pubmed: 36610254
pii: S0376-8716(22)00489-6
doi: 10.1016/j.drugalcdep.2022.109752
pmc: PMC9875721
mid: NIHMS1863169
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
109752Subventions
Organisme : NIAAA NIH HHS
ID : R00 AA024778
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest The authors have no conflicts of interest to declare.
Références
Hum Brain Mapp. 2014 Nov;35(11):5401-13
pubmed: 24867528
Drug Alcohol Depend. 2018 Apr 1;185:198-206
pubmed: 29462767
Neurosci Biobehav Rev. 2017 Jan;72:111-128
pubmed: 27894828
Cereb Cortex. 2014 Nov;24(11):2981-90
pubmed: 23765157
Eur Psychiatry. 2019 Oct;62:107-115
pubmed: 31561167
Psychiatr Q. 2017 Dec;88(4):807-825
pubmed: 28194549
J Consult Clin Psychol. 2011 Jun;79(3):307-18
pubmed: 21534653
Drug Alcohol Depend. 2022 Jan 1;230:109131
pubmed: 34864568
Hum Brain Mapp. 2016 Nov;37(11):3979-3998
pubmed: 27354150
Alcohol Clin Exp Res. 1995 Aug;19(4):1018-23
pubmed: 7485811
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
J Affect Disord. 2021 Apr 1;284:27-30
pubmed: 33582429
J Pers Soc Psychol. 2003 Aug;85(2):348-62
pubmed: 12916575
Am J Psychiatry. 2002 Oct;159(10):1760-6
pubmed: 12359684
Addiction. 2023 Jan;118(1):30-47
pubmed: 35851975
Alcohol Clin Exp Res. 2018 Jan;42(1):89-99
pubmed: 29105114
Drug Alcohol Depend. 2010 Jul 1;110(1-2):137-43
pubmed: 20347232
Addiction. 1993 Jun;88(6):791-804
pubmed: 8329970
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Biol Psychiatry. 2014 May 1;75(9):738-45
pubmed: 24267410
Biol Psychiatry. 2007 Jun 1;61(11):1306-9
pubmed: 17306772
Front Psychiatry. 2019 Apr 09;10:227
pubmed: 31057439
Emotion. 2020 Feb;20(1):1-9
pubmed: 31961170
Am J Drug Alcohol Abuse. 2021 May 4;47(3):373-382
pubmed: 33524279
Alcohol Clin Exp Res. 2014 Jul;38(7):1912-23
pubmed: 24890898
Soc Cogn Affect Neurosci. 2012 Jan;7(1):11-22
pubmed: 22228751
Psychophysiology. 2002 May;39(3):281-91
pubmed: 12212647
J Stud Alcohol. 2001 Sep;62(5):675-86
pubmed: 11702807
Biol Mood Anxiety Disord. 2012 Dec 07;2:22
pubmed: 23216889
J Child Adolesc Subst Abuse. 2014 May 1;23(3):200-204
pubmed: 24748761
Psychol Med. 2021 Oct;51(13):2189-2200
pubmed: 33879270
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Feb;5(2):239-250
pubmed: 31892465