Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.
Healthy conditions
Humans
Major depression
Obsessive-compulsive disorder
Oxytocin
Post-traumatic stress disorder
Sex
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
12
07
2022
revised:
12
12
2022
accepted:
12
12
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
Oxytocin (OT) is involved in the regulation of physiological processes and emotional states, with increasing evidence for its beneficial actions being mediated by the autonomic and immune systems. Growing evidence suggests that OT plays a role in the pathophysiology of different psychiatric disorders. Given the limited information in humans the aim of this study was to retrospectively explore plasma OT levels in psychiatric patients, particularly focusing on sex-related differences, as compared with healthy controls. The patients studied here were divided into three groups diagnosed with obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). Plasma OT levels were significantly different between healthy men and women, with the latter showing higher values, while none of the three psychiatric groups showed sex-related differences in the parameters measured here. The intergroup analyses showed that the OT levels were significantly higher in OCD, lower in PTSD and even more reduced in MDD patients than in healthy subjects. These differences were also confirmed when gender was considered, with the exception of PTSD men, in whom OT levels were similar to those of healthy men. The present results indicated that OT levels were higher amongst healthy women than men, while a sex difference was less apparent or reversed in psychiatric patients. Reductions in sex differences in psychopathologies may be related to differential vulnerabilities in processes associated with basic adaptive and social functions.
Identifiants
pubmed: 36590869
doi: 10.1016/j.cpnec.2022.100165
pii: S2666-4976(22)00056-X
pmc: PMC9800179
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100165Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
None.
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