Dysregulation of complement factor H in juvenile-onset systemic lupus erythematosus patients.
Complement factor H
factor H autoantibodies
juvenile-onset systemic lupus erythematosus
nephritis.
Journal
Archives of rheumatology
ISSN: 2618-6500
Titre abrégé: Arch Rheumatol
Pays: Turkey
ID NLM: 101639000
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
11
09
2021
accepted:
11
11
2021
entrez:
2
1
2023
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
This study aims to evaluate the expression pattern of factor H in peripheral blood and the frequency of factor H autoantibodies in plasma of juvenile-onset systemic lupus erythematosus (jSLE) patients compared to healthy controls. Between March 2019 and October 2019, a total of 30 healthy individuals (3 males, 27 females; mean age: 26±7.4 years; range, 18 to 40 years) and 65 jSLE patients (age of onset ≤16 years) (2 males, 63 females; mean age: 23.4±7 years; range, 15 to 38 years) were included. Factor H expression pattern was examined in blood of all subjects using quantitative real-time polymerase chain reaction and the frequency of factor H autoantibodies was estimated in plasma using enzyme-linked immunosorbent assay. Factor H expression was significantly downregulated in jSLE patients compared to healthy controls (p<0.01). A significant underexpression of factor H was observed in jSLE patients with nephritis compared to those without nephritis (p<0.03), while there was no association of factor H expression levels with any of the other clinical and serological features, disease activity or disease damage index of patients. Only 5% of jSLE patients were positive for factor H autoantibodies without any correlations with the clinical data or disease activity of patients. Our study results suggest that factor H expression can be dysregulated in jSLE patients.
Identifiants
pubmed: 36589613
doi: 10.46497/ArchRheumatol.2022.9217
pmc: PMC9791549
doi:
Types de publication
Journal Article
Langues
eng
Pagination
417-423Informations de copyright
Copyright © 2022, Turkish League Against Rheumatism.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
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