Polymeric Nanoparticles for Drug Delivery in Osteoarthritis.
cartilage
nanoparticles
osteoarthritis
polymers
therapeutics
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
29 Nov 2022
29 Nov 2022
Historique:
received:
28
10
2022
revised:
25
11
2022
accepted:
26
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial joint and globally impacts more than one in five individuals aged 40 and over, representing a huge socioeconomic burden. Drug penetration into and retention within the joints are major challenges in the development of regenerative therapies for OA. During the recent years, polymeric nanoparticles (PNPs) have emerged as promising drug carrier candidates due to their biodegradable properties, nanoscale structure, functional versatility, and reproducible manufacturing, which makes them particularly attractive for cartilage penetration and joint retention. In this review, we discuss the current development state of natural and synthetic PNPs for drug delivery and OA treatment. Evidence from in vitro and pre-clinical in vivo studies is used to show how disease pathology and key cellular pathways of joint inflammation are modulated by these nanoparticle-based therapies. Furthermore, we compare the biodegradability and surface modification of these nanocarriers in relation to the drug release profile and tissue targeting. Finally, the main challenges for nanoparticle delivery to the cartilage are discussed, as a function of disease state and physicochemical properties of PNPs such as size and surface charge.
Identifiants
pubmed: 36559133
pii: pharmaceutics14122639
doi: 10.3390/pharmaceutics14122639
pmc: PMC9788411
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Horizon 2020 (Marie Sklodowska-Curie Actions)
ID : 955335
Références
J Control Release. 2016 Dec 28;244(Pt B):357-365
pubmed: 27565216
Best Pract Res Clin Rheumatol. 2008 Apr;22(2):351-84
pubmed: 18455690
P T. 2017 Dec;42(12):742-755
pubmed: 29234213
Osteoarthritis Cartilage. 2014 Aug;22(8):1167-75
pubmed: 24911520
J Antimicrob Chemother. 2002 Feb;49 Suppl 1:21-30
pubmed: 11801577
Biomaterials. 2003 Feb;24(3):401-16
pubmed: 12423595
ACS Nano. 2021 Sep 28;15(9):14475-14491
pubmed: 34409835
J Biomed Mater Res A. 2016 Mar;104(3):595-599
pubmed: 26507256
Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
pubmed: 19782542
Biochem Biophys Res Commun. 2006 Mar 3;341(1):202-8
pubmed: 16413501
Nanoscale. 2019 Apr 4;11(14):6693-6709
pubmed: 30900717
Connect Tissue Res. 2020 Jan;61(1):34-47
pubmed: 31522568
ChemMedChem. 2015 Jan;10(1):24-38
pubmed: 25319803
Am Rev Respir Dis. 1987 Jun;135(6):1345-52
pubmed: 3592407
Bioact Mater. 2021 Jul 07;7:14-25
pubmed: 34466714
Nat Biomed Eng. 2021 Sep;5(9):1069-1083
pubmed: 34413494
J Control Release. 2017 Jul 28;258:161-170
pubmed: 28495577
Int J Pharm. 2020 May 15;581:119249
pubmed: 32217157
Biomaterials. 2011 Nov;32(32):8291-303
pubmed: 21810539
J Control Release. 2019 Sep 10;309:265-276
pubmed: 31362078
Osteoarthritis Cartilage. 2019 Nov;27(11):1578-1589
pubmed: 31278997
Arthritis Rheumatol. 2014 Jul;66(7):1820-31
pubmed: 24740822
Int J Mol Sci. 2022 Aug 11;23(16):
pubmed: 36012214
Pharm Res. 2015 Dec;32(12):3886-98
pubmed: 26134451
Pain Med. 2012 Jun;13(6):740-53
pubmed: 22621287
Sci Transl Med. 2021 Jan 13;13(576):
pubmed: 33441426
Br J Clin Pharmacol. 1994 Oct;38(4):349-55
pubmed: 7833225
Drug Dev Ind Pharm. 2018 Aug;44(8):1285-1294
pubmed: 29482400
J Control Release. 2021 Mar 10;331:491-502
pubmed: 33561482
Acta Biomater. 2019 Jul 15;93:239-257
pubmed: 30862551
Colloids Surf B Biointerfaces. 2019 May 1;177:399-406
pubmed: 30785037
Nanoscale Res Lett. 2018 Feb 07;13(1):44
pubmed: 29417375
Colloids Surf B Biointerfaces. 2022 Aug 23;219:112786
pubmed: 36049252
Biomedicines. 2021 Jul 08;9(7):
pubmed: 34356857
Lancet. 2019 Apr 27;393(10182):1745-1759
pubmed: 31034380
AMB Express. 2020 Aug 31;10(1):158
pubmed: 32865763
Cytokines Cell Mol Ther. 2000 Jun;6(2):71-9
pubmed: 11108572
Nanomaterials (Basel). 2022 Jun 30;12(13):
pubmed: 35808084
Tissue Eng Part B Rev. 2010 Dec;16(6):617-27
pubmed: 20836752
Langmuir. 2009 Feb 17;25(4):2369-77
pubmed: 19161268
J Control Release. 2020 Jul 10;323:47-58
pubmed: 32278830
Drug Deliv. 2018 Nov;25(1):1004-1012
pubmed: 29667446
J Bone Joint Surg Am. 2018 Apr 18;100(8):666-677
pubmed: 29664853
JAMA. 2001 Aug 22-29;286(8):954-9
pubmed: 11509060
Polymers (Basel). 2020 Feb 13;12(2):
pubmed: 32069893
PLoS One. 2014 Jan 02;9(1):e84703
pubmed: 24392152
EClinicalMedicine. 2020 Nov 26;29-30:100587
pubmed: 34505846
J Nanobiotechnology. 2013 Jul 19;11:26
pubmed: 23870291
Transl Neurodegener. 2015 Sep 30;4:18
pubmed: 26448863
Adv Healthc Mater. 2014 Oct;3(10):1562-7, 1525
pubmed: 24687997
Chem Rev. 2016 Feb 24;116(4):2602-63
pubmed: 26854975
Pharmaceutics. 2021 Dec 15;13(12):
pubmed: 34959445
Int Immunopharmacol. 2015 Sep;28(1):34-43
pubmed: 26002585
F1000Res. 2019 Jun 21;8:
pubmed: 31249675
Sci Rep. 2016 Jan 05;6:18743
pubmed: 26728350
PM R. 2012 May;4(5 Suppl):S97-103
pubmed: 22632709
Nat Mater. 2008 Mar;7(3):248-54
pubmed: 18246072
Adv Exp Med Biol. 2014;802:31-47
pubmed: 24443019
BMC Musculoskelet Disord. 2017 Dec 21;18(1):542
pubmed: 29268731
Am J Transl Res. 2019 Nov 15;11(11):6775-6789
pubmed: 31814887
Arthritis Rheumatol. 2014 Oct;66(10):2816-27
pubmed: 24966136
J Control Release. 2014 Sep 28;190:371-80
pubmed: 24818766
Drug Des Devel Ther. 2016 Nov 16;10:3779-3787
pubmed: 27895468
Colloids Surf B Biointerfaces. 2021 Oct;206:111973
pubmed: 34303997
Int J Biol Macromol. 2021 Feb 15;170:469-478
pubmed: 33359610
Bone Res. 2016 Mar 01;4:15040
pubmed: 26962464
BMC Musculoskelet Disord. 2010 Oct 10;11:232
pubmed: 20932341
Ann Intern Med. 2020 Oct 6;173(7):509-515
pubmed: 32744862
Acta Biomater. 2021 Mar 15;123:31-50
pubmed: 33444800
Osteoarthritis Cartilage. 2019 Sep;27(9):1347-1360
pubmed: 31132406
Int J Mol Sci. 2014 Feb 28;15(3):3640-59
pubmed: 24590126
Bone. 2012 Aug;51(2):249-57
pubmed: 22387238
Stem Cell Rev Rep. 2020 Dec;16(6):1222-1241
pubmed: 32556944
Sports Health. 2009 Nov;1(6):461-8
pubmed: 23015907
Mol Pharm. 2019 Feb 4;16(2):469-479
pubmed: 28669194
J Control Release. 2008 Mar 3;126(2):97-110
pubmed: 18201788
Nano Today. 2015 Aug;10(4):487-510
pubmed: 26640510
J Control Release. 2020 Dec 10;328:985-999
pubmed: 32860929
Adv Healthc Mater. 2021 Oct;10(20):e2100883
pubmed: 34137218
Bioconjug Chem. 2007 Jan-Feb;18(1):138-45
pubmed: 17226966
Front Bioeng Biotechnol. 2021 Jan 13;8:618399
pubmed: 33520968
Nat Rev Genet. 2014 Aug;15(8):541-55
pubmed: 25022906
Gene Ther. 2004 Feb;11(4):379-89
pubmed: 14724685
Nanomaterials (Basel). 2020 Nov 28;10(12):
pubmed: 33260493
Int J Pharm. 2017 Oct 30;532(1):66-81
pubmed: 28801107
J Biomech. 1997 Sep;30(9):895-902
pubmed: 9302612
Int J Pharm. 2020 Nov 30;590:119947
pubmed: 33031875
Curr Opin Rheumatol. 2018 Mar;30(2):160-167
pubmed: 29227353
Clin Geriatr Med. 2010 Aug;26(3):355-69
pubmed: 20699159
Cell. 1990 Jun 29;61(7):1303-13
pubmed: 1694723
Bioeng Transl Med. 2020 Sep 10;6(1):e10187
pubmed: 33532587
Clin Sports Med. 2017 Jul;36(3):413-425
pubmed: 28577703
Pharmaceutics. 2021 Feb 23;13(2):
pubmed: 33672354
Front Immunol. 2020 May 05;11:730
pubmed: 32431699
Front Bioeng Biotechnol. 2019 Oct 11;7:259
pubmed: 31681741
Biomacromolecules. 2017 Aug 14;18(8):2539-2551
pubmed: 28719196
Osteoarthritis Cartilage. 1996 Mar;4(1):23-34
pubmed: 8731393
Nat Rev Rheumatol. 2014 Jan;10(1):11-22
pubmed: 24189839
Nanomaterials (Basel). 2020 Jul 19;10(7):
pubmed: 32707641
Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):407-22
pubmed: 22009557
Eur J Pharm Biopharm. 2019 Apr;137:37-45
pubmed: 30772432
Sci Rep. 2020 Aug 10;10(1):13477
pubmed: 32778777
J Biomed Mater Res A. 2014 Feb;102(2):373-80
pubmed: 23520014
Eur J Pharm Biopharm. 1998 Nov;46(3):255-63
pubmed: 9885296
Ann Rheum Dis. 2018 Oct;77(10):1524-1534
pubmed: 29991473
Int J Biol Macromol. 2020 May 8;158:1082-1089
pubmed: 32389649
Signal Transduct Target Ther. 2021 Mar 19;6(1):122
pubmed: 33737507
Arthritis Res Ther. 2011 Jul 29;13(4):R125
pubmed: 21801403
J Biomater Sci Polym Ed. 2013;24(4):398-416
pubmed: 23565683
Int J Pharm. 2020 Jun 15;583:119378
pubmed: 32360505
Cell Physiol Biochem. 2018;47(3):1207-1216
pubmed: 29913441
Part Fibre Toxicol. 2017 Jun 24;14(1):22
pubmed: 28646905
Sci Rep. 2019 May 15;9(1):7430
pubmed: 31092864
Int J Mol Med. 2018 Nov;42(5):2604-2614
pubmed: 30106112
Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12
pubmed: 18796312
ACS Biomater Sci Eng. 2018 Apr 9;4(4):1251-1264
pubmed: 30349873
J Drug Target. 2006 Sep;14(8):519-26
pubmed: 17050118
J Aging Res. 2012;2012:950192
pubmed: 22720159
Arthritis Rheum. 2009 Mar 15;61(3):344-52
pubmed: 19248129
Biomaterials. 2021 Aug;275:120967
pubmed: 34153786
Nanomaterials (Basel). 2020 Apr 01;10(4):
pubmed: 32244653
Nat Commun. 2017 May 11;8:15019
pubmed: 28492224
Nanomedicine (Lond). 2018 Mar 1;13(5):539-554
pubmed: 29381129
Int J Nanomedicine. 2020 Apr 08;15:2379-2390
pubmed: 32308389
Biomedicines. 2021 Jul 27;9(8):
pubmed: 34440106
J Bone Joint Surg Am. 2003;85-A Suppl 2:106-10
pubmed: 12721352
Adv Drug Deliv Rev. 2020;160:170-185
pubmed: 33122086
Immunol Res. 2014 May;58(2-3):186-92
pubmed: 24614953
Int J Pharm. 2021 Nov 20;609:121198
pubmed: 34662644
Nat Rev Rheumatol. 2017 Mar;13(3):183-193
pubmed: 28202920
ACS Nano. 2021 Nov 23;15(11):16982-17015
pubmed: 34181394
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Mar-Apr;8(2):271-99
pubmed: 26314803
Arthritis Rheum. 2012 Jun;64(6):1697-707
pubmed: 22392533
Osteoarthritis Cartilage. 2021 May;29(5):654-666
pubmed: 33588087