Sugar-decorated carbon dots: a novel tool for targeting immunomodulatory receptors.
Journal
Nanoscale advances
ISSN: 2516-0230
Titre abrégé: Nanoscale Adv
Pays: England
ID NLM: 101738708
Informations de publication
Date de publication:
06 Dec 2022
06 Dec 2022
Historique:
received:
10
06
2022
accepted:
14
10
2022
entrez:
21
12
2022
pubmed:
22
12
2022
medline:
22
12
2022
Statut:
epublish
Résumé
Interactions between sialic acid (Sia) and sialic acid-binding immunoglobulin-like lectins (siglecs) regulate the immune system, with aberrations contributing to pathologies such as autoimmunity, infectious disease and cancer. Over the last decade, several multivalent Sia ligands have been synthesized to modulate the Sia-binding affinity of proteins/lectins. Here, we report a novel class of multivalent siglec probes through the decoration of α(2,6)-sialyllactose ligands on inherently fluorescent carbon dots (CD). We show that the preference of α(2,3)-linked Sia for siglec-1 can be altered by increasing the multivalence of Sia ligands present on the CD, and that a locally high glycan concentration can have a direct effect on linkage specificity. Additionally, micromolar (IC
Identifiants
pubmed: 36540112
doi: 10.1039/d2na00364c
pii: d2na00364c
pmc: PMC9729803
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5355-5364Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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