The Association of Coronary Artery Calcium Score and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study.
Atherosclerosis
Coronary artery calcium score
Coronary vessels
Osteocalcin
Osteoporosis
Journal
Journal of bone metabolism
ISSN: 2287-6375
Titre abrégé: J Bone Metab
Pays: Korea (South)
ID NLM: 101599927
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
24
08
2022
accepted:
06
11
2022
entrez:
18
12
2022
pubmed:
19
12
2022
medline:
19
12
2022
Statut:
ppublish
Résumé
The association between osteoporosis, a common metabolic bone disorder, and atherosclerosis has been reported in different studies. In this study, we aimed to investigate the association between the coronary artery calcium score (CACS) and bone mineral density (BMD) at different sites and bone biomarkers in postmenopausal women. A total of 184 participants were enrolled in this study. The CACS and BMD at different sites, including the spinal, total hip, and femoral neck, were measured using computed tomography angiography and dual energy X-ray absorptiometry, respectively. Serum levels of osteocalcin, β-C-terminal telopeptide (β-CTX), parathyroid hormone, and 25-hydroxy-vitamin D were measured. A negative association between CACS and bone biomarker levels (osteocalcin, P=0.021; β-CTX, P=0.013) was noted. The univariable model showed an association between CACS and osteoporosis of the femoral neck (P=0.03). It was found that with an increase of 10 U in CACS, the odds of osteoporosis at the femoral neck escalates by 2% (odds ratio=1.02, 95% confidence interval, 1.002-1.03) using the multivariate logistic regression model, while such an association with osteoporosis could not be found at the spinal site. The best cutoff point of the calcium score was estimated to be 127. The results suggest that in postmenopausal women, coronary atherosclerosis is independently associated with osteoporosis of the femoral neck, but such an association could not be detected with spinal osteoporosis. The importance of screening for osteoporosis in patients with cardiovascular disease and the implications of preventive measures in the primary care setting were highlighted considering the common risk factors.
Sections du résumé
BACKGROUND
BACKGROUND
The association between osteoporosis, a common metabolic bone disorder, and atherosclerosis has been reported in different studies. In this study, we aimed to investigate the association between the coronary artery calcium score (CACS) and bone mineral density (BMD) at different sites and bone biomarkers in postmenopausal women.
METHODS
METHODS
A total of 184 participants were enrolled in this study. The CACS and BMD at different sites, including the spinal, total hip, and femoral neck, were measured using computed tomography angiography and dual energy X-ray absorptiometry, respectively. Serum levels of osteocalcin, β-C-terminal telopeptide (β-CTX), parathyroid hormone, and 25-hydroxy-vitamin D were measured.
RESULTS
RESULTS
A negative association between CACS and bone biomarker levels (osteocalcin, P=0.021; β-CTX, P=0.013) was noted. The univariable model showed an association between CACS and osteoporosis of the femoral neck (P=0.03). It was found that with an increase of 10 U in CACS, the odds of osteoporosis at the femoral neck escalates by 2% (odds ratio=1.02, 95% confidence interval, 1.002-1.03) using the multivariate logistic regression model, while such an association with osteoporosis could not be found at the spinal site. The best cutoff point of the calcium score was estimated to be 127.
CONCLUSIONS
CONCLUSIONS
The results suggest that in postmenopausal women, coronary atherosclerosis is independently associated with osteoporosis of the femoral neck, but such an association could not be detected with spinal osteoporosis. The importance of screening for osteoporosis in patients with cardiovascular disease and the implications of preventive measures in the primary care setting were highlighted considering the common risk factors.
Identifiants
pubmed: 36529867
pii: jbm.2022.29.4.245
doi: 10.11005/jbm.2022.29.4.245
pmc: PMC9760776
doi:
Types de publication
Journal Article
Langues
eng
Pagination
245-254Subventions
Organisme : Elite Researcher Grant
ID : 958346
Organisme : National Institutes for Medical Research Development
Organisme : Endocrinology and Metabolism Research Institute, Osteoporosis Research Center of Tehran University of Medical Sciences
Références
Circulation. 2019 Jun 18;139(25):e1082-e1143
pubmed: 30586774
Int J Cardiol Heart Vasc. 2020 Aug 18;30:100618
pubmed: 32904231
J Am Coll Cardiol. 1997 Jun;29(7):1542-8
pubmed: 9180117
Osteoporos Int. 2018 Jul;29(7):1609-1616
pubmed: 29704026
Osteoporos Int. 2016 Jan;27(1):367-76
pubmed: 26510847
J Am Coll Cardiol. 1990 Mar 15;15(4):827-32
pubmed: 2407762
Bone. 2019 Apr;121:116-120
pubmed: 30659977
Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):e55-71
pubmed: 21757657
Diabetes Metab. 2012 Feb;38(1):76-81
pubmed: 21996253
N Engl J Med. 2007 Jun 21;356(25):2591-602
pubmed: 17582069
Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):e6-10
pubmed: 14670933
J Am Heart Assoc. 2019 May 7;8(9):e011444
pubmed: 31020897
Stat Med. 2012 Oct 15;31(23):2676-86
pubmed: 22307964
Osteoporos Int. 2006 Dec;17(12):1726-33
pubmed: 16983459
Atherosclerosis. 2015 Jul;241(1):278-83
pubmed: 25690697
Clin Exp Pharmacol Physiol. 2018 Jan;45(1):3-9
pubmed: 28921598
Calcif Tissue Int. 2001 May;68(5):271-6
pubmed: 11683533
Am J Obstet Gynecol. 2006 Feb;194(2 Suppl):S3-11
pubmed: 16448873
J Bone Metab. 2017 Feb;24(1):15-21
pubmed: 28326297
N Engl J Med. 2008 Mar 27;358(13):1336-45
pubmed: 18367736
Endocr J. 2021 Feb 28;68(2):137-144
pubmed: 33087644
Circulation. 1996 May 1;93(9):1755-64
pubmed: 8653883
Osteoporos Int. 2007 Jul;18(7):999-1008
pubmed: 17285350
Clin Cases Miner Bone Metab. 2008 Jan;5(1):19-34
pubmed: 22460842
Clin Endocrinol (Oxf). 2011 Aug;75(2):196-201
pubmed: 21521333
J Bone Miner Res. 2015 Oct;30(10):1767-74
pubmed: 25871790
Int J Cardiol. 2010 Apr 15;140(2):249-52
pubmed: 19097653
Nutrients. 2018 Oct 04;10(10):
pubmed: 30287742
BMC Cardiovasc Disord. 2010 Apr 21;10:19
pubmed: 20409295
Climacteric. 2016 Oct;19(5):458-62
pubmed: 27397609
Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2302-9
pubmed: 17717292
J Bone Miner Metab. 2011 May;29(3):369-76
pubmed: 21069548
Osteoporos Int. 2013 Aug;24(8):2223-30
pubmed: 23563931
Calcif Tissue Int. 2006 Aug;79(2):102-11
pubmed: 16927045
Arq Bras Cardiol. 2018 Mar;110(3):211-216
pubmed: 29694545
Lancet. 1991 Aug 10;338(8763):355-8
pubmed: 1677708
Osteoporos Int. 2014 Jan;25(1):85-95
pubmed: 23884437
Osteoporos Int. 2019 Sep;30(9):1755-1765
pubmed: 31227885
Clin Endocrinol (Oxf). 2009 Nov;71(5):644-51
pubmed: 19226260
Front Endocrinol (Lausanne). 2017 Jul 31;8:183
pubmed: 28824544
PLoS One. 2016 May 05;11(5):e0154740
pubmed: 27149062
Vasc Health Risk Manag. 2014 Aug 26;10:533-8
pubmed: 25210458
Osteoporos Int. 2014 Feb;25(2):455-65
pubmed: 23775420
Bone. 2016 Feb;83:178-183
pubmed: 26576474
Pol J Radiol. 2014 Jun 30;79:169-74
pubmed: 24995072
J Bone Miner Res. 2006 Dec;21(12):1839-46
pubmed: 17002567
Osteoporos Int. 2010 Jun;21 Suppl 2:S407-13
pubmed: 20464374
Circulation. 2007 Dec 11;116(24):2841-50
pubmed: 18040026
Am J Epidemiol. 2009 Jan 15;169(2):186-94
pubmed: 19064643