Alteration of oral microbiome composition in children living with pesticide-exposed farm workers.
Agriculture
Children
Exposure
Microbiome
Organophosphate
Pesticide
Journal
International journal of hygiene and environmental health
ISSN: 1618-131X
Titre abrégé: Int J Hyg Environ Health
Pays: Germany
ID NLM: 100898843
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
08
06
2022
revised:
30
08
2022
accepted:
30
11
2022
pmc-release:
01
03
2024
pubmed:
15
12
2022
medline:
8
2
2023
entrez:
14
12
2022
Statut:
ppublish
Résumé
Our prior work shows that azinphos-methyl pesticide exposure is associated with altered oral microbiomes in exposed farmworkers. Here we extend this analysis to show the same association pattern is also evident in their children. Oral buccal swab samples were analyzed at two time points, the apple thinning season in spring-summer 2005 for 78 children and 101 adults and the non-spray season in winter 2006 for 62 children and 82 adults. The pesticide exposure for the children were defined by the farmworker occupation of the cohabitating household adult and the blood azinphos-methyl detection of the cohabitating adult. Oral buccal swab 16S rRNA sequencing determined taxonomic microbiota proportional composition from concurrent samples from both adults and children. Analysis of the identified bacteria showed significant proportional changes for 12 of 23 common oral microbiome genera in association with azinphos-methyl detection and farmworker occupation. The most common significantly altered genera had reductions in the abundance of Streptococcus, suggesting an anti-microbial effect of the pesticide. Principal component analysis of the microbiome identified two primary clusters, with association of principal component 1 to azinphos-methyl blood detection and farmworker occupational status of the household. The children's buccal microbiota composition clustered with their household adult in ∼95% of the households. Household adult farmworker occupation and household pesticide exposure is associated with significant alterations in their children's oral microbiome composition. This suggests that parental occupational exposure and pesticide take-home exposure pathways elicit alteration of their children's microbiomes.
Identifiants
pubmed: 36516690
pii: S1438-4639(22)00173-0
doi: 10.1016/j.ijheh.2022.114090
pmc: PMC9898171
mid: NIHMS1857566
pii:
doi:
Substances chimiques
Pesticides
0
Azinphosmethyl
265842EWUV
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
114090Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103524
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN267200700023C
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES009601
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES015459
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier GmbH. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.
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