ERK contributes to B cell receptor-induced cell spreading in the A20 mouse B cell line.
Journal
microPublication biology
ISSN: 2578-9430
Titre abrégé: MicroPubl Biol
Pays: United States
ID NLM: 101759238
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
11
2022
revised:
01
01
1970
accepted:
21
11
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
13
12
2022
Statut:
epublish
Résumé
B cells provide protective immunity by secreting antibodies. When a B cell encounters its specific antigen, B-cell receptor (BCR) signaling initiates actin remodeling. This allows B cells to spread on antigen-bearing surfaces and find more antigen, which increases BCR signaling and facilitates B cell activation. The BCR activates multiple signaling pathways that target actin-regulatory proteins. Although the extracellular signal-regulated kinases ERK1 and ERK2 regulate actin-dependent processes in adherent cells, their role in BCR-induced actin remodeling had not been investigated. Here, we show that targeting ERK with chemical inhibitors or siRNA inhibits BCR-induced spreading in a murine B cell line.
Identifiants
pubmed: 36506348
doi: 10.17912/micropub.biology.000665
pmc: PMC9729986
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright: © 2022 by the authors.
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