Phenotypic Characterization and Heterogeneity among Modern Clinical Isolates of Acinetobacter baumannii.
Acinetobacter baumannii
Gram-negative bacteria
bacterial capsule
capsular polysaccharide
genotypes
macrocolonies
phenotypes
transmission electron microscopy
virulence factors
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
14 02 2023
14 02 2023
Historique:
pubmed:
9
12
2022
medline:
17
2
2023
entrez:
8
12
2022
Statut:
ppublish
Résumé
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents the hallmark of A. baumannii bacteria. We wondered to what extent extensively used strains, so-called reference strains, reflect the dynamic nature and intrinsic heterogeneity of these bacteria. We analyzed multiple phenotypic traits of 43 nonredundant, modern, and multidrug-resistant, extensively drug-resistant, and pandrug-resistant clinical isolates and broadly used strains of A. baumannii. Comparison of these isolates at the genetic and phenotypic levels confirmed a high degree of heterogeneity. Importantly, we observed that a significant portion of modern clinical isolates strongly differs from several historically established strains in the light of colony morphology, cellular density, capsule production, natural transformability, and
Identifiants
pubmed: 36475894
doi: 10.1128/spectrum.03061-22
pmc: PMC9927488
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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