Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 02 2023
06 02 2023
Historique:
received:
12
04
2022
revised:
12
09
2022
accepted:
08
11
2022
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
10
12
2022
Statut:
ppublish
Résumé
Arachnoid granulations (AG) are poorly investigated. Historical reports suggest that they regulate brain volume by passively transporting cerebrospinal fluid (CSF) into dural venous sinuses. Here, we studied the microstructure of cerebral AG in humans with the aim of understanding their roles in physiology. We discovered marked variations in AG size, lobation, location, content, and degree of surface encapsulation. High-resolution microscopy shows that AG consist of outer capsule and inner stromal core regions. The fine and porous framework suggests uncharacterized functions of AG in mechanical CSF filtration. Moreover, internal cytokine and immune cell enrichment imply unexplored neuroimmune properties of these structures that localize to the brain-meningeal lymphatic interface. Dramatic age-associated changes in AG structure are additionally identified. This study depicts for the first time microscopic networks of internal channels that communicate with perisinus spaces, suggesting that AG subserve important functions as transarachnoidal flow passageways. These data raise new theories regarding glymphatic-lymphatic coupling and mechanisms of CSF antigen clearance, homeostasis, and diseases.
Identifiants
pubmed: 36469302
pii: 213737
doi: 10.1084/jem.20220618
pmc: PMC9728136
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R21 AG079221
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 Shah et al.
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