Naringenin and Its Derivatives-Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans.
anti-inflammatory activity
antifungal activity
antimicrobial activity
antioxidant activity
naringenin
naringenin derivatives
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
15 Nov 2022
15 Nov 2022
Historique:
received:
27
10
2022
revised:
09
11
2022
accepted:
13
11
2022
entrez:
24
11
2022
pubmed:
25
11
2022
medline:
25
11
2022
Statut:
epublish
Résumé
Naringenin is a trihydroxyflavanone present in large amount in different citrus fruits, e.g., oranges, pomelos, grapefruits, but also in tomatoes, fenugreek and coffee. It has a wide range of pharmacological and biological effects beneficial to human health. Its antioxidant, anti-cancer, anti-inflammatory, antifungal and antimicrobial activity is frequently reported in scientific literature. In this review we presented the current state of knowledge on the antimicrobial activity of naringenin and its natural and synthetic derivatives as a phytobiotic against resistant Gram-positive and Gram-negative bacteria as well as fungi in humans. Most of the data reported here have been obtained from in vitro or in vivo studies. Over the past few years, due to the overuse of antibiotics, the occurrence of bacteria resistant to all available antibiotics has been growing. Therefore, the main focus here is on antibiotic resistant strains, which are a significant, worldwide problem in the treatment of infectious diseases. The situation is so alarming that the WHO has listed microbial resistance to drugs on the list of the 10 most important health problems facing humanity. In addition, based on scientific reports from recent years, we described the potential molecular mechanism of action of these bioflavonoids against pathogenic strains of microorganisms. As plant-derived substances have been pushed out of use with the beginning of the antibiotic era, we hope that this review will contribute to their return as alternative methods of preventing and treating infections in the epoch of drug resistance.
Identifiants
pubmed: 36421272
pii: antibiotics11111628
doi: 10.3390/antibiotics11111628
pmc: PMC9686724
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Int J Med Sci. 2020 Oct 18;17(18):3049-3057
pubmed: 33173425
Sci Rep. 2016 Dec 22;6:39735
pubmed: 28004841
Adv Nutr. 2021 Mar 31;12(2):413-428
pubmed: 32879962
Fitoterapia. 2013 Apr;86:92-9
pubmed: 23425602
Biochem Biophys Res Commun. 2000 Dec 29;279(3):949-54
pubmed: 11162455
Pharmaceuticals (Basel). 2019 Jan 10;12(1):
pubmed: 30634637
Integr Biol (Camb). 2017 Oct 16;9(10):820-829
pubmed: 28862705
Biochim Biophys Acta. 1993 Apr 8;1147(1):132-6
pubmed: 8466924
Int J Biochem Cell Biol. 2006;38(5-6):985-95
pubmed: 16289850
ACS Omega. 2020 Aug 07;5(32):20080-20089
pubmed: 32832762
J Agric Food Chem. 2005 Mar 23;53(6):2140-5
pubmed: 15769147
Int J Food Microbiol. 2000 May 25;56(1):3-12
pubmed: 10857921
J Cell Mol Med. 2021 Mar;25(5):2563-2571
pubmed: 33523599
Molecules. 2015 Sep 29;20(10):17903-12
pubmed: 26426003
Clin Nutr. 2003 Dec;22(6):561-8
pubmed: 14613759
Molecules. 2019 Feb 14;24(4):
pubmed: 30769816
J Clin Med. 2019 Dec 31;9(1):
pubmed: 31906141
Life Sci. 2016 Sep 1;160:47-56
pubmed: 27449398
Phytomedicine. 2013 Feb 15;20(3-4):262-9
pubmed: 23218402
Protein Sci. 2008 Nov;17(11):1971-8
pubmed: 18780820
Biomolecules. 2019 Mar 12;9(3):
pubmed: 30871083
Planta Med. 1999 Jun;65(5):442-3
pubmed: 10454900
J Cell Biochem. 2017 May;118(5):1118-1131
pubmed: 27606834
Ci Ji Yi Xue Za Zhi. 2019 Apr-Jun;31(2):81-85
pubmed: 31007486
Clin Infect Dis. 2007 Nov 15;45(10):1335-7
pubmed: 17968830
Diabetes Obes Metab. 2020 Jan;22(1):91-98
pubmed: 31468636
Planta Med. 2005 Mar;71(3):197-201
pubmed: 15770537
Int J Environ Res Public Health. 2013 Oct 28;10(11):5459-69
pubmed: 24169409
Pharmaceuticals (Basel). 2021 Aug 01;14(8):
pubmed: 34451853
J Biol Chem. 2017 Mar 10;292(10):4064-4076
pubmed: 28119451
IUBMB Life. 2021 Jul;73(7):953-967
pubmed: 33934490
Arch Pharm Res. 2004 May;27(5):507-11
pubmed: 15202555
Microbiol Res. 2010 Aug 20;165(6):496-504
pubmed: 19840899
Diabetes Obes Metab. 2008 Nov;10(11):1097-104
pubmed: 18355329
Molecules. 2014 Nov 04;19(11):17862-71
pubmed: 25375331
J Appl Microbiol. 2010 Aug;109(2):515-527
pubmed: 20163489
Chem Biol Interact. 2020 Nov 1;331:109218
pubmed: 32916141
PLoS One. 2016 Apr 05;11(4):e0153015
pubmed: 27045367
Pathol Oncol Res. 2013 Oct;19(4):763-70
pubmed: 23661153
Rep Biochem Mol Biol. 2018 Oct;7(1):76-84
pubmed: 30324121
Molecules. 2021 Mar 03;26(5):
pubmed: 33802449
Gen Pharmacol. 1996 Oct;27(7):1237-40
pubmed: 8981074
J Dent. 2018 Sep;76:24-31
pubmed: 29679633
J Physiol Pharmacol. 2012 Oct;63(5):497-503
pubmed: 23211303
Genes (Basel). 2020 Oct 22;11(11):
pubmed: 33105635
Environ Sci Pollut Res Int. 2022 May;29(21):31025-31041
pubmed: 35119637
Biochem Pharmacol. 2017 Jun 15;134:139-146
pubmed: 27956111
World J Gastroenterol. 2018 Apr 28;24(16):1679-1707
pubmed: 29713125
Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E744-53
pubmed: 12799318
Clin Interv Aging. 2007;2(2):219-36
pubmed: 18044138
Molecules. 2020 Aug 10;25(16):
pubmed: 32785151
Int J Food Microbiol. 2008 Jun 10;124(3):295-8
pubmed: 18456359
Carbohydr Polym. 2017 Oct 15;174:243-252
pubmed: 28821064
J Agric Food Chem. 2013 Nov 20;61(46):11033-40
pubmed: 24156563
ACS Appl Mater Interfaces. 2017 Jun 14;9(23):19698-19705
pubmed: 28548484
Br J Pharmacol. 2013 Apr;168(8):1835-50
pubmed: 23190005
J Nutr. 2002 Nov;132(11):3349-52
pubmed: 12421849
Free Radic Res. 1999 Feb;30(2):153-62
pubmed: 10193583
Nutrients. 2022 Feb 17;14(4):
pubmed: 35215494
Diabetes Obes Metab. 2014 Jul;16(7):602-12
pubmed: 24205999
Indian J Exp Biol. 2008 Nov;46(11):783-7
pubmed: 19090350
Heliyon. 2020 Oct 08;6(10):e05174
pubmed: 33083621
J Biol Chem. 2012 Jun 1;287(23):19315-25
pubmed: 22493492
J Appl Microbiol. 2011 Sep;111(3):731-8
pubmed: 21672094
Front Microbiol. 2015 Oct 13;6:1129
pubmed: 26528273
Pharmacol Res Perspect. 2021 Aug;9(4):e00825
pubmed: 34310866
Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33
pubmed: 20805405
Phytomedicine. 2000 Apr;7(2):161-5
pubmed: 10839220
Microbiology (Reading). 2013 Jan;159(Pt 1):167-175
pubmed: 23125118
3 Biotech. 2019 Aug;9(8):312
pubmed: 31406634
Trends Immunol. 2017 Jan;38(1):5-19
pubmed: 27793571
Lett Appl Microbiol. 2010 Jul;51(1):83-9
pubmed: 20497495
Mol Plant Pathol. 2012 May;13(4):414-30
pubmed: 22471698
Chem Biodivers. 2017 Feb;14(2):
pubmed: 27647729
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S154-S160
pubmed: 28479741
Mol Nutr Food Res. 2011 May;55 Suppl 1:S26-34
pubmed: 21280205
Life Sci. 2016 Jan 1;144:80-5
pubmed: 26656314
J Anal Methods Chem. 2014;2014:296838
pubmed: 25180132
Br J Nutr. 2011 Dec;106(11):1713-23
pubmed: 21736771
Br J Biomed Sci. 2008;65(3):145-7
pubmed: 18986103
Molecules. 2007 Jul 09;12(7):1352-66
pubmed: 17909491
Eur J Med Chem. 2014 Jun 10;80:92-100
pubmed: 24769347
J Nutr Biochem. 2013 Jul;24(7):1276-84
pubmed: 23333096
Microbiology (Reading). 2011 Jul;157(Pt 7):2120-2132
pubmed: 21546585
Pharm Acta Helv. 2000 Apr;74(4):379-85
pubmed: 10812937
Molecules. 2017 Jun 30;22(7):
pubmed: 28665345
Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):481-490
pubmed: 29138066
Environ Toxicol. 2020 Dec;35(12):1386-1394
pubmed: 32667124
J Nutr Biochem. 2016 Jul;33:8-14
pubmed: 27260463
J Nat Prod. 2009 Apr;72(4):719-24
pubmed: 19236029
Molecules. 2017 Sep 06;22(9):
pubmed: 28878189
Int J Food Microbiol. 2011 Jan 31;145(1):28-36
pubmed: 21168230
J Appl Microbiol. 2007 Dec;103(6):2056-64
pubmed: 18045389