Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies.
Alzheimer’s disease
amyloid beta
dementia
oxidative stress
phosphorylated tau
tauopathy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Oct 2022
25 Oct 2022
Historique:
received:
11
09
2022
revised:
21
10
2022
accepted:
22
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer's brain. These proteins are highly expressed in nerve cells and found in most tissues. Tau primarily provides stabilization to microtubules in the part of axons and dendrites. However, tau in a pathological state becomes hyperphosphorylated, causing tau dysfunction and leading to synaptic impairment and degeneration of neurons. This article presents a summary of the role of tau, phosphorylated tau (p-tau) in AD, and other tauopathies. Tauopathies, including Pick's disease, frontotemporal dementia, corticobasal degeneration, Alzheimer's disease, argyrophilic grain disease, progressive supranuclear palsy, and Huntington's disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells. This article also focuses on current research on the post-translational modifications and genetics of tau, tau pathology, the role of tau in tauopathies and the development of new drugs targeting p-tau, and the therapeutics for treating and possibly preventing tauopathies.
Identifiants
pubmed: 36361631
pii: ijms232112841
doi: 10.3390/ijms232112841
pmc: PMC9654278
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
tau Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG042178
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG069333
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG060767
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047812
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG079264
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG066347
Pays : United States
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