Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance.
CMV retinitis
CMV viremia
HLA class I
HLA-E
NKG2A
UL40
human cytomegalovirus
natural killer cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
07
2022
accepted:
20
09
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
9
11
2022
Statut:
epublish
Résumé
Human cytomegalovirus (HCMV) infections develop into CMV diseases that result in various forms of manifestations in local organs. CMV-retinitis is a form of CMV disease that develops in immunocompromised hosts with CMV-viremia after viruses in the peripheral circulation have entered the eye. In the HCMV genome, extensive diversification of the UL40 gene has produced peptide sequences that modulate NK cell effector functions when loaded onto HLA-E and are subsequently recognized by the NKG2A and NKG2C receptors. Notably, some HCMV strains carry UL40 genes that encode peptide sequences identical to the signal peptide sequences of specific HLA-A and HLA-C allotypes, which enables these CMV strains to escape HLA-E-restricted CD8
Identifiants
pubmed: 36341392
doi: 10.3389/fimmu.2022.1008220
pmc: PMC9626817
doi:
Substances chimiques
Viral Proteins
0
Peptides
0
Protein Sorting Signals
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1008220Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR073752
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Shirane, Yawata, Motooka, Shibata, Khor, Omae, Kaburaki, Yanai, Mashimo, Yamana, Ito, Hayashida, Mori, Numata, Murakami, Fujiwara, Ohguro, Hosogai, Akiyama, Hasegawa, Paley, Takeda, Maenaka, Akashi, Yokoyama, Tokunaga, Yawata and Sonoda.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflict of interest.
Références
J Gen Virol. 2004 May;85(Pt 5):1301-1312
pubmed: 15105547
Blood. 2004 Dec 1;104(12):3664-71
pubmed: 15304389
Am J Ophthalmol. 2021 Jul;227:191-200
pubmed: 33773985
J Virol. 2007 Mar;81(5):2095-101
pubmed: 16956936
Nat Rev Immunol. 2022 Feb;22(2):112-123
pubmed: 34117484
J Infect Dis. 2011 Oct 1;204(7):1003-7
pubmed: 21881114
Ocul Immunol Inflamm. 2022 Feb 17;30(2):297-309
pubmed: 33617392
Curr Opin Ophthalmol. 2018 Nov;29(6):535-542
pubmed: 30281031
Mol Biol Cell. 2004 Dec;15(12):5197-207
pubmed: 15385624
Am J Ophthalmol. 2016 May;165:145-53
pubmed: 27005706
Am J Ophthalmol. 2020 May;213:252-259
pubmed: 31785234
Am J Ophthalmol. 2008 May;145(5):834-40
pubmed: 18255045
J Immunol. 2019 Oct 15;203(8):2301-2309
pubmed: 31519864
Immunogenetics. 2005 Nov;57(10):717-29
pubmed: 16215732
J Virol. 2015 May 13;89(15):7673-7695
pubmed: 25972543
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10896-901
pubmed: 12960383
Nature. 1998 Feb 19;391(6669):795-9
pubmed: 9486650
J Immunol. 2014 Nov 15;193(10):5065-75
pubmed: 25320280
PLoS Pathog. 2018 May 31;14(5):e1007040
pubmed: 29852019
Annu Rev Immunol. 2020 Apr 26;38:511-539
pubmed: 32340578
Hum Immunol. 2013 Oct;74(10):1313-20
pubmed: 23806270
J Biol Chem. 2013 Mar 22;288(12):8679-8690
pubmed: 23335510
J Mol Biol. 2008 Apr 11;377(5):1297-303
pubmed: 18339401
J Exp Med. 2005 Mar 21;201(6):891-902
pubmed: 15781581
Tissue Antigens. 2007 Nov;70(5):415-22
pubmed: 17854430
J Virol. 2010 Jul;84(14):7195-203
pubmed: 20463084
PLoS Pathog. 2018 Apr 30;14(4):e1007041
pubmed: 29709038
Nat Immunol. 2006 Mar;7(3):256-64
pubmed: 16474394
Blood. 2008 Sep 15;112(6):2369-80
pubmed: 18583565
Blood. 2007 Apr 1;109(7):2806-14
pubmed: 17179229
J Heart Lung Transplant. 2021 Sep;40(9):900-904
pubmed: 34183227
Cell Rep. 2019 Apr 9;27(2):537-548.e5
pubmed: 30970256
Science. 1995 Apr 21;268(5209):405-8
pubmed: 7716543
Bone Marrow Transplant. 2020 Jun;55(6):1147-1160
pubmed: 31992849
Tissue Antigens. 2005 May;65(5):437-47
pubmed: 15853898
Gene Ther. 2000 Jun;7(12):1063-6
pubmed: 10871756
Eur J Immunol. 1997 May;27(5):1164-9
pubmed: 9174606
Mol Immunol. 2020 Apr;120:101-112
pubmed: 32113130
Mucosal Immunol. 2016 Jan;9(1):159-70
pubmed: 26080707
Virus Res. 2011 May;157(2):151-60
pubmed: 21056604
Int J Mol Sci. 2021 Mar 31;22(7):
pubmed: 33807229
Transplantation. 2007 Jan 15;83(1):80-3
pubmed: 17220797
Nature. 1986 Feb 20-26;319(6055):675-8
pubmed: 3951539
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4120-8
pubmed: 26150505
Nat Immunol. 2018 May;19(5):453-463
pubmed: 29632329
Lancet Infect Dis. 2004 Dec;4(12):725-38
pubmed: 15567122
Ophthalmology. 2012 Sep;119(9):1892-8
pubmed: 22657564
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6696-701
pubmed: 18448674
PLoS One. 2011 Jan 28;6(1):e16635
pubmed: 21307958
Tissue Antigens. 2008 Nov;72(5):415-24
pubmed: 18946929
EMBO J. 1999 Aug 2;18(15):4250-60
pubmed: 10428963
Rev Med Virol. 2019 May;29(3):e2034
pubmed: 30706584
J Exp Med. 1998 Aug 3;188(3):497-503
pubmed: 9687527
Tissue Antigens. 2015 Apr;85(4):252-9
pubmed: 25789826
J Gen Virol. 2010 Mar;91(Pt 3):605-15
pubmed: 19906940
Int J Hematol. 2008 Apr;87(3):310-8
pubmed: 18320138
BMC Ophthalmol. 2019 Apr 3;19(1):87
pubmed: 30943921
J Immunol. 2013 Sep 1;191(5):2708-16
pubmed: 23918974
mBio. 2021 Mar 16;12(2):
pubmed: 33727352
Cornea. 2020 May;39(5):584-589
pubmed: 32068609
PLoS One. 2020 Sep 2;15(9):e0238257
pubmed: 32877457
Am J Ophthalmol. 2006 Mar;141(3):564-5
pubmed: 16490509
Nucleic Acids Res. 2020 Jan 8;48(D1):D783-D788
pubmed: 31722398
Jpn J Ophthalmol. 2021 Mar;65(2):184-190
pubmed: 33694024
PLoS One. 2012;7(11):e50951
pubmed: 23226431
Front Immunol. 2018 Oct 17;9:2410
pubmed: 30386347
Blood. 2010 Jun 10;115(23):4820-3
pubmed: 20385791
Front Immunol. 2018 Jan 25;9:60
pubmed: 29422902
J Exp Med. 2010 Jan 18;207(1):61-75
pubmed: 20065065
J Biol Chem. 2003 Feb 14;278(7):5082-90
pubmed: 12411439
J Immunol. 1998 Jan 1;160(1):189-96
pubmed: 9551971
Front Immunol. 2021 Apr 22;12:658570
pubmed: 33968060
J Immunol. 2018 Jan 1;200(1):49-60
pubmed: 29150562
J Clin Microbiol. 1988 Nov;26(11):2465-6
pubmed: 3069867
Retina. 2013 Oct;33(9):1791-9
pubmed: 23584702
Ocul Immunol Inflamm. 2019;27(2):211-218
pubmed: 30311824
J Immunol Res. 2016;2016:2695396
pubmed: 27699181
Microorganisms. 2019 Dec 28;8(1):
pubmed: 31905656
Am J Ophthalmol. 2013 May;155(5):781-6
pubmed: 23415597
Science. 2000 Feb 11;287(5455):1031
pubmed: 10669413
J Innate Immun. 2016;8(4):374-85
pubmed: 27116381
Ocul Immunol Inflamm. 2005 Jul-Aug;13(4):271-7
pubmed: 16159717