Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.

Humans Glaucoma / diagnosis Multifactorial Inheritance / genetics Risk Factors Risk Assessment Diagnostic Techniques, Ophthalmological

Journal

Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919

Informations de publication

Date de publication:
03 10 2022
Historique:
entrez: 28 10 2022
pubmed: 29 10 2022
medline: 2 11 2022
Statut: ppublish

Résumé

Integrating polygenic risk scores (PRS) into healthcare has the potential to stratify an individual's risk of glaucoma across a broad population. Glaucoma is the most common cause of irreversible blindness worldwide, therefore effective screening for glaucoma endorsed by the population is highly important. This study assessed the attitude of unaffected individuals toward PRS testing for glaucoma, and sought to identify factors associated with interest in testing. We surveyed 418 unaffected individuals including 193 with a first-degree relative with glaucoma, 117 who had a recent eye examination, and 108 general members of the community. Overall, 71.3% of the individuals indicated an interest in taking a polygenic risk test for glaucoma. Interest was more likely in those who believed glaucoma to be a severe medical condition (odds ratio [OR] = 14.58, 95% confidence interval [CI] = 1.15-185.50, P = 0.039), those concerned about developing glaucoma (OR = 4.37, 95% CI = 2.32-8.25, P < 0.001), those with an intention to take appropriate measures regarding eye health (OR = 2.39, 95% CI = 1.16-4.95, P = 0.019), and those preferring to know if considered to be at-risk or not (OR = 4.52, 95% CI = 2.32-8.83, P < 0.001). Our results show strong interest in genetic risk assessment for glaucoma among unaffected individuals in Australia. These findings represent a valuable assessment of interest in glaucoma polygenic risk testing among potential target populations, which will be integral to the implementation and uptake of novel PRS-based tests into clinical practice.

Identifiants

DOI: 10.1167/tvst.11.10.38 PMID: 36306122 PMC: PMC9624267
pubmed: 36306122
pii: 2783805
doi: 10.1167/tvst.11.10.38
pmc: PMC9624267
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

38

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Auteurs

Georgina L Hollitt (GL)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

Owen M Siggs (OM)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.
Garvan Institute of Medical Research Institute, Darlinghurst, Sydney, Australia.

Bronwyn Ridge (B)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

Miriam C Keane (MC)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

David A Mackey (DA)

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Lions Eye Institute, Centre for Ophthalmology and Vision Sciences, University of Western Australia, Perth, Western Australia, Australia.

Stuart MacGregor (S)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Alex W Hewitt (AW)

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Jamie E Craig (JE)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

Emmanuelle Souzeau (E)

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.

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Classifications MeSH

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Recherchemedicale.com › Maladies de l'oeil › Hypertension oculaire › Glaucome › Attitudes Toward Glaucoma Genetic Risk...
Recherchemedicale.com › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Attitudes Toward Glaucoma Genetic Risk...
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