Metabolomic profiles and microbiota of GDM offspring: The key for future perspective?
GDM
metabolomics
microbiome
microbiota
obesity
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
05
2022
accepted:
15
08
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
Gestational diabetes mellitus (GDM), or any degree of glucose intolerance recognized for the first time during pregnancy, is one of the diseases that most frequently aggravates the course of gestation. Missed or late diagnosis and inadequate treatment are associated with high maternal and fetal morbidity, with possible short- and long-term repercussions. Estimates on the prevalence of GDM are alarming and increasing by about 30% in the last 10-20 years. In addition, there is the negative influence of the SARS-CoV-2 emergency on the glycemic control of pregnant women, making the matter increasingly topical. To date, knowledge on the metabolic maturation of newborns is still incomplete. However, in light of the considerable progress of the theory of "developmental origins of health and disease," the relevant role of the intrauterine environment cannot be overlooked. In fact, due to the high plasticity of the early stages of development, some detrimental metabolic alterations during fetal growth, including maternal hyperglycemia, are associated with a higher incidence of chronic diseases in adult life. In this context, metabolomic analysis which allows to obtain a detailed phenotypic portrait through the dynamic detection of all metabolites in cells, tissues and different biological fluids could be very useful for the early diagnosis and prevention of complications. Indeed, if the diagnostic timing is optimized through the identification of specific metabolites, the detailed understanding of the altered metabolic pathway could also allow better management and more careful monitoring, also from a nutritional profile, of the more fragile children. In this context, a further contribution derives from the analysis of the intestinal microbiota, the main responsible for the fecal metabolome, given its alteration in pregnancies complicated by GDM and the possibility of transmission to offspring. The purpose of this review is to analyze the available data regarding the alterations in the metabolomic profile and microbiota of the offspring of mothers with GDM in order to highlight future prospects for reducing GDM-related complications in children of mothers affected by this disorder.
Identifiants
pubmed: 36275053
doi: 10.3389/fped.2022.941800
pmc: PMC9579340
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
941800Informations de copyright
Copyright © 2022 Dessì, Tognazzi, Bosco, Pintus and Fanos.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Diabetes Care. 2017 May;40(5):679-686
pubmed: 28279981
BMC Med. 2021 May 27;19(1):120
pubmed: 34039350
Diabetes Care. 2019 Mar;42(3):381-392
pubmed: 30617141
Diabetes. 2009 Feb;58(2):453-9
pubmed: 19011170
Diabetologia. 2018 May;61(5):1037-1045
pubmed: 29492638
J Matern Fetal Neonatal Med. 2014 Apr;27(6):537-42
pubmed: 23844701
N Engl J Med. 2008 May 8;358(19):1991-2002
pubmed: 18463375
Pediatr Res. 2022 Jun;91(7):1864-1873
pubmed: 34526650
Epigenetics. 2017 Aug;12(8):616-625
pubmed: 28486003
J Proteome Res. 2015 Apr 3;14(4):1799-809
pubmed: 25722016
Diabetologia. 2021 Nov;64(11):2466-2477
pubmed: 34401952
Clin Epigenetics. 2018 Oct 24;10(1):131
pubmed: 30355290
Diabetes. 2012 May;61(5):1272-80
pubmed: 22396200
Children (Basel). 2021 Sep 14;8(9):
pubmed: 34572236
Pediatr Diabetes. 2008 Feb;9(1):53-9
pubmed: 18036135
Gut. 2018 Sep;67(9):1614-1625
pubmed: 29760169
Diabetes. 2013 Apr;62(4):1320-8
pubmed: 23209187
Diabetes Care. 2016 Jun;39(6):982-7
pubmed: 27208333
Microbiol Spectr. 2021 Oct 31;9(2):e0117621
pubmed: 34704805
Diabetologia. 2011 Aug;54(8):1957-66
pubmed: 21626451
PLoS Genet. 2006 May;2(5):e81
pubmed: 16733553
Life (Basel). 2021 Feb 16;11(2):
pubmed: 33669262
Ann Nutr Metab. 2015;66 Suppl 2:14-20
pubmed: 26045324
Int J Mol Sci. 2020 Jul 15;21(14):
pubmed: 32679915
Curr Diab Rep. 2018 Jul 23;18(9):68
pubmed: 30039471
Diabetes Care. 2010 Aug;33(8):1845-9
pubmed: 20435793
Best Pract Res Clin Obstet Gynaecol. 2015 Feb;29(2):156-64
pubmed: 25271062
PLoS One. 2013 Nov 06;8(11):e78257
pubmed: 24223144
Pediatr Res. 2007 May;61(5 Pt 1):625-9
pubmed: 17413866
J Diabetes Res. 2021 May 18;2021:5516937
pubmed: 34113682
Diabetes Metab. 2021 Mar;47(2):101201
pubmed: 33069845
Biochem J. 2011 Jun 1;436(2):263-9
pubmed: 21375506
BJOG. 2021 Oct;128(11):1881-1887
pubmed: 34047455
Acta Diabetol. 2019 Apr;56(4):421-430
pubmed: 30725264
Diabetologia. 2016 Nov;59(11):2339-2348
pubmed: 27510911
Metabolites. 2021 Oct 22;11(11):
pubmed: 34822382
Expert Rev Endocrinol Metab. 2019 Jan;14(1):63-74
pubmed: 30063409
Acta Diabetol. 2018 Oct;55(10):1037-1042
pubmed: 29936651
PLoS One. 2019 Dec 16;14(12):e0226545
pubmed: 31841548
Int J Mol Sci. 2020 Jan 03;21(1):
pubmed: 31947745
Diabetologia. 2014 Nov;57(11):2413-20
pubmed: 25168408
Microbiol Mol Biol Rev. 2017 Nov 8;81(4):
pubmed: 29118049
Molecules. 2013 Sep 25;18(10):11724-32
pubmed: 24071981
Diabetes Care. 2011 Feb;34(2):480-4
pubmed: 21216858
Curr Diab Rep. 2016 Jan;16(1):7
pubmed: 26742932
Diabetes Res Clin Pract. 2020 May;163:108128
pubmed: 32259610
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
Trends Endocrinol Metab. 2018 Nov;29(11):743-754
pubmed: 30297319
Diabetes Care. 2017 Jul;40(7):902-910
pubmed: 28637888
Nat Genet. 2018 Jun;50(6):790-795
pubmed: 29808030
FASEB J. 2008 Nov;22(11):3925-37
pubmed: 18644838
Dev Neuropsychol. 2009;34(6):683-700
pubmed: 20183727
Lancet Diabetes Endocrinol. 2020 Apr;8(4):292-300
pubmed: 32135135
Diabetes Care. 2012 Apr;35(4):780-6
pubmed: 22357187
Acta Diabetol. 2020 May;57(5):569-581
pubmed: 31820107
BMJ. 2019 Dec 4;367:l6398
pubmed: 31801789
Pediatrics. 2008 Nov;122(5):e1073-9
pubmed: 18977957
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
PLoS One. 2018 Oct 17;13(10):e0205695
pubmed: 30332459
Sci Rep. 2020 Feb 27;10(1):3660
pubmed: 32107447
Diabetes Care. 2020 Jan;43(1):98-105
pubmed: 31601636
Nutrients. 2018 Feb 28;10(3):
pubmed: 29495552
Am J Obstet Gynecol. 2016 Sep;215(3):380.e1-7
pubmed: 27018463
Nutrients. 2019 Feb 03;11(2):
pubmed: 30717458
J Pediatr Endocrinol Metab. 2001 Sep-Oct;14(8):1085-91
pubmed: 11592564
Int J Mol Sci. 2018 Oct 26;19(11):
pubmed: 30373146
Int J Mol Sci. 2020 Dec 17;21(24):
pubmed: 33348910
PLoS One. 2017 Jun 26;12(6):e0179934
pubmed: 28650965
FEBS Lett. 2007 Jan 9;581(1):91-6
pubmed: 17182038
Int J Obes (Lond). 2014 Nov;38(11):1457-65
pubmed: 24549138
Clin Epigenetics. 2016 Jun 22;8:72
pubmed: 27340502
Front Endocrinol (Lausanne). 2022 May 26;13:875180
pubmed: 35721735
Acta Diabetol. 2019 Nov;56(11):1159-1167
pubmed: 31396699
Int J Mol Sci. 2021 May 28;22(11):
pubmed: 34071236
Diabetologia. 2019 Dec;62(12):2171-2178
pubmed: 31624900
Int J Gynaecol Obstet. 2015 Dec;131(3):251-4
pubmed: 26372349
Isr Med Assoc J. 2020 Sep;22(9):569-575
pubmed: 33236556
Nutrients. 2019 May 18;11(5):
pubmed: 31109059
Diabetes Care. 2008 Feb;31(2):340-6
pubmed: 18000174
J Diabetes Res. 2021 Nov 25;2021:9994734
pubmed: 34869780
Can J Infect Dis Med Microbiol. 2021 Sep 22;2021:3044534
pubmed: 34603565
Nutr Rev. 2016 Jun;74(6):411-20
pubmed: 27142302
Cell Host Microbe. 2018 Jul 11;24(1):133-145.e5
pubmed: 30001516
Nat Genet. 1998 Oct;20(2):163-9
pubmed: 9771709
Epigenetics. 2019 Mar;14(3):215-235
pubmed: 30865571
mSystems. 2017 Jan 17;2(1):
pubmed: 28144631
Medicine (Baltimore). 2018 Aug;97(34):e11891
pubmed: 30142788
Exp Diabetes Res. 2012;2012:963735
pubmed: 22927834
Sci Rep. 2020 Jan 31;10(1):1549
pubmed: 32005877
Diabetes Care. 2019 Jan;42(Suppl 1):S13-S28
pubmed: 30559228
Clin Chim Acta. 2013 Nov 15;426:127-38
pubmed: 24035970
J Pediatr Pharmacol Ther. 2013 Jul;18(3):199-208
pubmed: 24052783
Front Hum Neurosci. 2018 Aug 13;12:323
pubmed: 30150928
Curr Diab Rep. 2012 Feb;12(1):4-15
pubmed: 22094826
CMAJ. 2019 Apr 15;191(15):E410-E417
pubmed: 30988041
J Ultrasound Med. 2014 Aug;33(8):1365-9
pubmed: 25063401
Am J Clin Nutr. 2016 Mar;103(3):794-800
pubmed: 26817507
Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E117-24
pubmed: 15353408
Biomed Res Int. 2014;2014:981219
pubmed: 25247199
Nutrients. 2020 Apr 30;12(5):
pubmed: 32365792
Int J Obes (Lond). 2015 Dec;39(12):1733-41
pubmed: 26119994
Epigenetics. 2013 Sep;8(9):935-43
pubmed: 23975224
J Dev Orig Health Dis. 2020 Dec;11(6):599-616
pubmed: 31902382
Diabetes Care. 2008 Jul;31(7):1422-6
pubmed: 18375420
PLoS One. 2015 Nov 13;10(11):e0142583
pubmed: 26566144
Ital J Pediatr. 2020 Mar 27;46(1):37
pubmed: 32216818
Diabetes Care. 2010 Nov;33(11):2436-41
pubmed: 20724651
Dev Med Child Neurol. 2005 Aug;47(8):525-31
pubmed: 16108452