Sustained superiority in KOOS subscores after matrix-associated chondrocyte implantation using spheroids compared to microfracture.
Humans
Aged
Adolescent
Young Adult
Adult
Middle Aged
Chondrocytes
/ transplantation
Cartilage, Articular
/ injuries
Activities of Daily Living
Fractures, Stress
/ surgery
Prospective Studies
Quality of Life
Transplantation, Autologous
/ methods
Cartilage Diseases
/ surgery
Knee Joint
/ surgery
Magnetic Resonance Imaging
/ methods
Autologous chondrocyte implantation
Cartilage defect
Cartilage lesion
KOOS
Knee surgery
MOCART
Randomized clinical trial
Journal
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
ISSN: 1433-7347
Titre abrégé: Knee Surg Sports Traumatol Arthrosc
Pays: Germany
ID NLM: 9314730
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
07
01
2022
accepted:
03
10
2022
medline:
16
5
2023
pubmed:
22
10
2022
entrez:
21
10
2022
Statut:
ppublish
Résumé
To evaluate the safety and efficacy of matrix-associated autologous chondrocyte implantation (ACI) using spheroids in comparison to arthroscopic microfracture for the treatment of symptomatic cartilage defects of the knee. In a prospective multicenter-controlled trial, patients aged between 18 and 50 years, with single symptomatic focal cartilage defects between 1 and 4 cm The overall KOOS and its five subscores were significantly improved compared to baseline for both the ACI and microfracture group. Non-inferiority of ACI to microfracture was confirmed for the overall KOOS and the subscores, while for the subscores activities of daily living, quality of life and sports and recreation of the threshold for superiority was passed. In the ACI group, a notably more rapid initial improvement of the KOOS was found at three months for the older age group compared to the younger age group and the microfracture group. No other differences were found based on age or defect size. In addition, clinical improvement was found for the MOCART, modified Lysholm and IKDC examination form both the ACI and microfracture group. No safety concern related to either treatment was observed. This study confirms the safety and efficacy of matrix-associated ACI with spheroids at a mid to long-term follow-up. Non-inferiority of ACI to microfracture was confirmed for the overall KOOS and all subscores, while superiority was reached for the subscores activities of daily living, quality of life and sports and recreation in the ACI group. This underlines the importance of ACI for the young and active patients. I.
Identifiants
pubmed: 36269383
doi: 10.1007/s00167-022-07194-x
pii: 10.1007/s00167-022-07194-x
doi:
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2482-2493Informations de copyright
© 2022. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA).
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