The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19).
COVID-19
Diabetes
Macrovascular disease
Mortality
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
19 10 2022
19 10 2022
Historique:
received:
21
08
2022
accepted:
24
09
2022
entrez:
19
10
2022
pubmed:
20
10
2022
medline:
22
10
2022
Statut:
epublish
Résumé
It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19. We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020-October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to determine associations between previous macrovascular disease and relevant clinical outcomes: mortality, intensive care unit (ICU) admission and use of invasive mechanical ventilation (IMV) during the hospitalization. Output from individual logistic regression models for each cohort was combined in a meta-analysis. Complete data were available for 4,106 (60.4%) individuals. Of these, 1,652 (40.2%) had any prior macrovascular disease of whom 28.5% of patients died. Mortality was higher for people with compared to those without previous macrovascular disease (37.7% vs 22.4%). The combined crude odds ratio (OR) for previous macrovascular disease and mortality for all four cohorts was 2.12 (95% CI 1.83-2.45 with an I This large multinational study of people with diabetes mellitus hospitalized for COVID-19 demonstrates that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization suggesting selective admission criteria. Our findings highlight the importance correctly assess the prognosis and intensive monitoring in this high-risk group of patients and emphasize the need to design specific public health programs aimed to prevent SARS-CoV-2 infection in this subgroup.
Sections du résumé
BACKGROUND
It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19.
METHODS
We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020-October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to determine associations between previous macrovascular disease and relevant clinical outcomes: mortality, intensive care unit (ICU) admission and use of invasive mechanical ventilation (IMV) during the hospitalization. Output from individual logistic regression models for each cohort was combined in a meta-analysis.
RESULTS
Complete data were available for 4,106 (60.4%) individuals. Of these, 1,652 (40.2%) had any prior macrovascular disease of whom 28.5% of patients died. Mortality was higher for people with compared to those without previous macrovascular disease (37.7% vs 22.4%). The combined crude odds ratio (OR) for previous macrovascular disease and mortality for all four cohorts was 2.12 (95% CI 1.83-2.45 with an I
CONCLUSIONS
This large multinational study of people with diabetes mellitus hospitalized for COVID-19 demonstrates that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization suggesting selective admission criteria. Our findings highlight the importance correctly assess the prognosis and intensive monitoring in this high-risk group of patients and emphasize the need to design specific public health programs aimed to prevent SARS-CoV-2 infection in this subgroup.
Identifiants
pubmed: 36261811
doi: 10.1186/s12933-022-01657-8
pii: 10.1186/s12933-022-01657-8
pmc: PMC9580453
doi:
Types de publication
Meta-Analysis
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
216Investigateurs
Juan Antonio Arroyo
(JA)
Juan-José Chillarón
(JJ)
Rosa Corcoy
(R)
Roberto Güerri
(R)
Manel Mata-Cases
(M)
Emilio Ortega
(E)
Matthieu Pichelin
(M)
Maëva Saignes
(M)
Jeanne Saunier
(J)
Selma El Andaloussi
(SE)
Joëlle Martin-Gauthier
(J)
Emily Rebouilleau
(E)
Tanguy Roman
(T)
Pascale Mahot
(P)
Matthieu Pichelin
(M)
Anne-Laure Fournier-Guilloux
(AL)
Nicolas Mauduit
(N)
Edith Bigot- Corbel
(EB)
Anne-Sophie Boureau
(AS)
Laure De Dekcer
(L)
Audrey Ernould
(A)
Claire Primot
(C)
Anne Seguin
(A)
Marielle Joliveau
(M)
Sonia Pouvreau
(S)
Chloé Fournier
(C)
Jeremy Thureau
(J)
Edith Fonteneau
(E)
Pamela Hublain
(P)
Carole Agasse
(C)
Mathilde De Kergaradec
(M)
Vincent Minville
(V)
Fanny Vardon-Bounes
(F)
Guillaume Martin-Blondel
(G)
Blandine Tramunt
(B)
Marie-Christine Turnin
(MC)
Hélène Hanaire
(H)
Jean-Michel Mansuy
(JM)
Didier Fabre
(D)
Marie-Blanche Arhainx
(MB)
Laurent Cazals
(L)
Laure Combes
(L)
Emmanuelle Lami
(E)
Bruno Megarbane
(B)
Pierre Leroy
(P)
Jean-François Gautier
(JF)
Tiphaine Vidal-Trecan
(T)
Jean-Pierre Riveline
(JP)
Jean-Louis Laplanche
(JL)
Stéphane Mouly
(S)
Louis Potier
(L)
Ronan Roussel
(R)
Malak Taher
(M)
Yawa Abouleka
(Y)
Fetta Yaker
(F)
Aurelie Carlier
(A)
Anne Boutten
(A)
Marilyne Hallot-Feron
(M)
Fadila Mourah
(F)
Charles Thivolet
(C)
Emilie Blond
(E)
Muriel Rolland
(M)
Josep Verdecho Mendez
(JV)
Marine Alexandre
(M)
Julien Pottecher
(J)
Emilie Richer
(E)
Laurent Meyer
(L)
Florina Luca
(F)
Jean-Marc Lessinger
(JM)
Thibault Bahougne
(T)
Bruno Guerci
(B)
Siham Benzirar
(S)
Catherine Malaplate
(C)
Thierry Matton
(T)
Julien Poissy
(J)
Karine Faure
(K)
Pierre Fontaine
(P)
Florence Baudoux
(F)
Anne Vambergue
(A)
Jean David Pekar
(JD)
Marc Lambert
(M)
Cécile Yelnik
(C)
Amélie Bruandet
(A)
Laurent Petit
(L)
Didier Neau
(D)
Vincent Rigalleau
(V)
Annie Berard
(A)
Amandine Galioot
(A)
Remy Coudroy
(R)
Arnaud Thille
(A)
René Robert
(R)
France Roblot-Cazenave
(F)
Blandine Rammaert
(B)
Pierre Jean Saulnier
(PJ)
Xavier Piguel
(X)
Nesrine Benhenda
(N)
Camille Husson
(C)
Celine Olivier
(C)
Florence Torremocha
(F)
Mathilde Fraty
(M)
Marie Flamen D'assigny
(MF)
Aurelie Miot
(A)
Valentin Bossard
(V)
Kada Klouche
(K)
Alain Makinson
(A)
Ariane Sultan
(A)
Jean-Baptiste Bonnet
(JB)
Vincent Foulongne
(V)
Florence Galtier
(F)
Cécile Aubron
(C)
Séverine Ansart
(S)
Véronique Kerlan
(V)
Pascale Quiniou
(P)
Jean- Luc Carre
(JL)
Stéphane Quesnot
(S)
Bruno Laviolle
(B)
Carole Schwebel
(C)
Olivier Epaulard
(O)
Pierre-Yves Benhamou
(PY)
Cécile Betry
(C)
Anne-Laure Borel
(AL)
Sandrine Lablanche
(S)
Dorra Guergour
(D)
Catherine Duclos
(C)
Emmanuel Cosson
(E)
Erwan Guyot
(E)
Aurore Deniau
(A)
Phucthutrang Nguyen
(P)
Yves Reznik
(Y)
Michael Joubert
(M)
Stéphane Allouche
(S)
Lydia Guittet
(L)
Steven Grange
(S)
Manuel Etienne
(M)
Gaëtan Prévost
(G)
Valéry Brunel
(V)
Jean-Christophe Lagier
(JC)
Didier Raoult
(D)
Anne Dutour
(A)
Bénédicte Gaborit
(B)
Sandrine Boulllu
(S)
Patrice Darmon
(P)
Adèle Lasbleiz
(A)
Mathieu Cerino
(M)
Fanny Romain
(F)
Marie Houssays
(M)
Jean Pierre Quenot
(JP)
Lionel Piroth
(L)
Bruno Vergès
(B)
Laurence Duvillard
(L)
Bernard Bonnotte
(B)
Alain Mercat
(A)
Vincent Dubee
(V)
Ingrid Allix
(I)
Patrice Rodien
(P)
Robin Dhersin
(R)
Maylis Lebeault
(M)
Wojciech Trzepizur
(W)
Jocelyne Loison
(J)
Antoine Brangier
(A)
Pierre Asfar
(P)
Pascal Reynier
(P)
Françoise Larcher
(F)
Françoise Joubaud
(F)
Marie-Rita Andreu
(MR)
Geoffrey Urbanski
(G)
Laurent Hubert
(L)
Cedric Annweiler
(C)
Jean Dellamonica
(J)
Johan Courjon
(J)
Nicolas Chevalier
(N)
Giulia Chinetti
(G)
Magda Chafai
(M)
Bruno Mourvillier
(B)
Firouze Bani-Sadr
(F)
Sarra Barraud
(S)
Brigitte Delemer
(B)
Philippe Gillery
(P)
Pascale Labedade
(P)
Amélie Chabrol
(A)
Alfred Penfornis
(A)
Catherine Petit
(C)
Coralie Amadou
(C)
Maxime Adler
(M)
Clément Dubost
(C)
Pierre-Louis Conan
(PL)
Lyse Bordier
(L)
Franck Ceppa
(F)
Cyril Garcia
(C)
Mathilde Sollier
(M)
Olivier Dupuy
(O)
Sophie Laplance
(S)
Olivier Billuart
(O)
Marie Joseph Aroulanda
(MJ)
Frédérique Olivier
(F)
Florence Ayon
(F)
Nathalie Wilhelm
(N)
Loic Epelboin
(L)
Nadia Sabbah
(N)
Aurelie Charpin
(A)
Pierre Squara
(P)
Olivier Belliard
(O)
Claude Dubois
(C)
Michel Marre
(M)
Johann Auchabie
(J)
Roxane Courtois
(R)
Thierry Duriez
(T)
Tiphaine Mergey
(T)
Laura Vallee
(L)
Laetitia Seguin
(L)
Abdallah Al-Salameh
(A)
Jean-Philippe Lanoix
(JP)
Sandrine Soriot-Thomas
(S)
Anne-Marie Bourgeois-Descouls
(AM)
Rachel Desailloud
(R)
Natacha Germain
(N)
Bogdan Galusca
(B)
Gwenaelle Belleton
(G)
Nesrine Marouani
(N)
Delia Palaghiu
(D)
Amira Hammour
(A)
Fernando Berdaguer
(F)
Thimothée Klopfenstein
(T)
Hajer Zayet
(H)
Patrice Winiszewski
(P)
Marie Zanusso
(M)
Pauline Garnier
(P)
Ingrid Julier
(I)
Karim Hamzaoui
(K)
Sophie Marty-Gres
(S)
Tarik El Sadki
(TE)
Lucile Cadot
(L)
Jean-Louis Dubost
(JL)
Céline Gonfroy
(C)
Catherine Campinos
(C)
Pascale Martres
(P)
Marie Pierre Coulhon
(MP)
Nicolas Allou
(N)
Marwa Bachir
(M)
Stella Hoang
(S)
Candice Kembellec
(C)
Olivia Suply
(O)
Fatima Kharcha
(F)
Anne-Claire Devouge
(AC)
Anna Flaus-Furmanuk
(A)
Isabelle Madeline
(I)
Vincent Ehinger
(V)
Sophie Bastard
(S)
Loic Raffray
(L)
Frederic Renou
(F)
Aude Bojarsk
(A)
Karine Borsu
(K)
Angelique Gorlin
(A)
Servane Di Bernardo
(S)
Carole Truong Van Ut
(CT)
Stephane Renaud
(S)
Antoine Vignoles
(A)
Emilie Foch
(E)
Laurie Masse
(L)
Hubert Grand
(H)
Helene Ferrand
(H)
Christelle Raffaitin-Cardin
(C)
Hadjer Zellagui
(H)
Celine Castang-Brachet
(C)
Frederique Boury
(F)
Ana Alvarez Tena
(AA)
Isabelle Moura
(I)
Pierre Kalfon
(P)
Louis Pasteur
(L)
Juliana Darasteanu
(J)
Louis Pasteur
(L)
Arnaud Monier
(A)
Louis Pasteur
(L)
Pascal Foucault
(P)
Louis Pasteur
(L)
Alexandra Depuille
(A)
Louis Pasteur
(L)
Stéphanie Laugier-Robiolle
(S)
Patrick Caneiro
(P)
Maud Basso
(M)
Etienne Larger
(E)
Samir Bouam
(S)
Wahiba Benzenati
(W)
Leila Ait Bachir
(LA)
Camille Cussac Pillegand
(CC)
Marc Vasse
(M)
Christophe Michard
(C)
Nathanaëlle Montanier
(N)
Luc Millot
(L)
Françoise Crepet
(F)
Danielle Ratsimba
(D)
Kevin Bouiller
(K)
Sophie Borot
(S)
Isabelle Bruckert
(I)
Annie Clergeot
(A)
Franck Schillo
(F)
Dorothée Vignes
(D)
Muriel Bourgeon-GhittoriLachgar
(M)
Claire Lambert De Cursay
(CL)
Stéphane Levante
(S)
Jean Charles Auregan
(JC)
Antoine Merlet
(A)
Cécile Zaragoza
(C)
Gwénaëlle Arnault
(G)
Anne-Gaëlle Le Loupp
(AG)
Olivier Lesieur
(O)
Mariam Roncato-Saberan
(M)
Didier Gouet
(D)
Romain Lemari
(R)
Hong-An Allano
(HA)
Emmanuel Vivier
(E)
Caroline Pariset
(C)
Cédric Luyton
(C)
Lucien Marchand
(L)
Fanny Doroszewski
(F)
Matthieu Pecquet
(M)
Laurent Perard
(L)
Sylvie Vuillermoz-Blas
(S)
Nicolas Kacki
(N)
Patricia Charrier
(P)
Amélie Ducet-Boiffard
(A)
Françoise Desroys Du Roure
(FD)
Olivier Bourron
(O)
Dominique Bonnefont-Rousselot
(D)
Suzanne Laroche
(S)
Franck Phan
(F)
Agnès Hartemann
(A)
Cyrielle Caussy
(C)
Emmanuel Disse
(E)
Emilie Blond
(E)
Claude Guerin
(C)
Thomas Perpoint
(T)
Philippe Moulin
(P)
Régine Cartier
(R)
Geoffroy Hariri
(G)
Dorothée Chopin
(D)
Camille Vatier
(C)
Nathalie Bourcigaux
(N)
Emmanuelle Chaigneau
(E)
Sophie Christin-Maitre
(S)
Bruno Donadille
(B)
Bruno Feve
(B)
Sophie Lamothe
(S)
Julie Sarfati
(J)
Pascal Pernet
(P)
Anne Chambon
(A)
Delphine Demarsy
(D)
Hugo Campagne
(H)
Françoise Latil-Plat
(F)
Monica Berne
(M)
Marilyne Grinand
(M)
Marion Touzet
(M)
Aydrey Zabulon
(A)
Jocelyne Craspag
(J)
Catherine Ledoux
(C)
Cedric Contaret
(C)
Blandine Janand-Delenne
(B)
Anaïs Giraud
(A)
Marie Lou Lacrimini
(ML)
Joëlle Arrivie
(J)
Deborah Ancelle
(D)
Carine Guillois
(C)
Bénédicte Fremy
(B)
Amina Chaalal
(A)
Gaëlle Barrande
(G)
Anne Dorange
(A)
Eglantine Rouanet
(E)
Dominique Seret-Begue
(D)
Audrey Saoud
(A)
Anne-Marie Guedj
(AM)
Nathalie Bedos
(N)
Fritz-Line Velayoudom
(FL)
Marie Dumas
(M)
Benoite Gonda
(B)
Christine Coffin
(C)
Stéphanie Gibiat
(S)
Myriam Lungo
(M)
Chantal Bully
(C)
Pierre Serusclat
(P)
Stella Bully
(S)
Patricia Carre
(P)
Jean-Philippe Leberre
(JP)
Carlos Elkhoury
(C)
Marine Thieux
(M)
Laetitia Paradisi-Prieur
(L)
Emma Wilmot
(E)
Sarah Wild
(S)
Ben Field
(B)
Parth Narendran
(P)
Rajiv Gandhi
(R)
Sophie Harris
(S)
Dinesh Nagi
(D)
Robert Ryder
(R)
Jim Davies
(J)
Steve Harris
(S)
Oliver Freeman
(O)
Ben Maylor
(B)
Kinga A Várnai
(KA)
Gail Roadknight
(G)
Melissa Cul
(M)
Amy Edwards
(A)
Susan Gelding
(S)
Kirun Gunganah
(K)
Pyei Aung
(P)
Moulinath Banerjee
(M)
Ali Chakera
(A)
Dominique Rouse
(D)
Syed Haris Ahmed
(SH)
Ho Yee Cheung
(HY)
Hywel Roberts
(H)
Susan Seal
(S)
Syed Saah Shah
(SS)
Amir Hayat
(A)
Cynthia Mohandas
(C)
Htet Htet Aung
(HH)
Su Khant Chel
(SK)
Nyan Lin
(N)
Kavitia Narula
(K)
Furruq Quadri
(F)
Su Lei Yin
(SL)
Yin Yin
(Y)
Alamin Alkundi
(A)
Abdelmajid Musa
(A)
Emma Birbeck
(E)
Charles Bodmer
(C)
Irene Bossman
(I)
Sathis Kumar
(S)
Umesh Dashora
(U)
Elizabeth Toubi
(E)
Mansoor Zafar
(M)
Vinod Patel
(V)
Amitha Gopinath
(A)
Belinda Allan
(B)
Remat Karim
(R)
Dharshana Appuhamillage
(D)
Khubaib Ayoub
(K)
Sophie Harris
(S)
Charmaine Ilangaratne
(C)
Maliha Iqbal
(M)
Rory Maclean
(R)
Omar Mustafa
(O)
Susan Baxter
(S)
Malgorzata Adamus
(M)
Kevin Baynes
(K)
Siva Sivappriyan
(S)
Ryan D'Costa
(R)
Dinesh Nagi
(D)
Vernon Parfitt
(V)
Mazharul Islam
(M)
Sadia Nasir
(S)
Gail Roadknight
(G)
Kinga Várnai
(K)
Senthil Vasan
(S)
Vilashini Arul Devah
(VA)
Foteini Kavvoura
(F)
Lina Ficken
(L)
James Gilham
(J)
Vincent Simpson
(V)
Neil Walker
(N)
Umaira Aziz
(U)
Efthimia Karra
(E)
Dipesh Patel
(D)
Miranda Rosenthal
(M)
Tracy Curran
(T)
Angela Paisley
(A)
Melissa Cull
(M)
Parijat De P
(P)
May Thin Khine
(MT)
Pari Qayyam
(P)
Robert Ryder
(R)
Priscilla Sarkar
(P)
Rajiv Gandhi
(R)
Ben Field
(B)
James Clark
(J)
Vesna Hogan
(V)
Lauren Jackson
(L)
Jamie-Leigh Williamson
(JL)
R Younes
(R)
Lucy Robin
(L)
Lydia Grixti
(L)
Suann Tee
(S)
Abilash Sathya
(A)
Emma Wilmot
(E)
Mayank Patel
(M)
Catherine Holmes
(C)
Wasim Hanif
(W)
Sandip Ghosh
(S)
Parth Narendran
(P)
Ehtasham Ahmad
(E)
Ejaz Ahmed
(E)
Melanie Davies
(M)
Steven Hartshorn
(S)
Kamlesh Khunti
(K)
Lee Simons
(L)
David Webb
(D)
Ben Maylor
(B)
Jim Davies
(J)
Oliver Freeman
(O)
Steve Harris
(S)
Anupam Brahma
(A)
Seshadri Pramodh
(S)
Katy Frew
(K)
Alison Mackenzie
(A)
Abigail Wild
(A)
Helen Casey
(H)
Deborah Morrison
(D)
Conor McKeag
(C)
Anne Sillars
(A)
Angus Stirling
(A)
Fiona Smeeton
(F)
Syed Muhammad
(S)
Kofi Obuobie
(K)
Win Yin
(W)
Neera Agarwal
(N)
Mike Atkinson
(M)
Sai Ambati
(S)
Rahim Khan
(R)
Preethi Nalla
(P)
Arshiya Tabasum
(A)
Stamatios Zouras
(S)
Akhila Mallipedhi
(A)
Richard Chudleigh
(R)
David Williams
(D)
Mallory Cianferani
(M)
Lisa Ludwig
(L)
Caroline Paul
(C)
Hamoud Lachgar
(H)
Informations de copyright
© 2022. The Author(s).
Références
Diabetes Res Clin Pract. 2022 Aug;190:109984
pubmed: 35803315
Diabetes Obes Metab. 2020 Oct;22(10):1915-1924
pubmed: 32573903
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Front Endocrinol (Lausanne). 2022 Jan 13;12:777130
pubmed: 35095757
Cardiovasc Diabetol. 2021 Jul 10;20(1):140
pubmed: 34246277
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Lancet Infect Dis. 2021 Apr;21(4):e69-e70
pubmed: 32679085
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Nutr Metab Cardiovasc Dis. 2022 Nov;32(11):2588-2593
pubmed: 36064691
Lancet Diabetes Endocrinol. 2020 Sep;8(9):782-792
pubmed: 32687793
Cardiovasc Diabetol. 2021 Aug 12;20(1):165
pubmed: 34384426
J Clin Virol. 2020 Jun;127:104354
pubmed: 32305882
Ann Transl Med. 2020 Jun;8(11):693
pubmed: 32617313
Lancet Diabetes Endocrinol. 2021 Feb;9(2):82-93
pubmed: 33357491
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Endocrinol Diabetes Metab. 2022 May;5(3):e00338
pubmed: 35441801
Diabetologia. 2021 Apr;64(4):778-794
pubmed: 33599800
Diabetes Care. 2022 Jan 1;45(Suppl 1):S175-S184
pubmed: 34964873
BMJ Open. 2021 Jul 22;11(7):e051237
pubmed: 34301668
Diabetes Metab Syndr. 2022 May;16(5):102484
pubmed: 35472685
Nat Rev Endocrinol. 2021 Jan;17(1):11-30
pubmed: 33188364
Research (Wash D C). 2020 Apr 19;2020:2402961
pubmed: 32377638
Lancet Diabetes Endocrinol. 2020 Oct;8(10):813-822
pubmed: 32798472
Diabetologia. 2022 Sep;65(9):1436-1449
pubmed: 35701673
Diabetologia. 2020 Aug;63(8):1500-1515
pubmed: 32472191
Diabetes. 2020 Dec;69(12):2549-2565
pubmed: 32938731