Fecal microbiota composition is related to brown adipose tissue
Brown fat
Glucose uptake
Gut microbiota
Obesity
Short-chain fatty acids
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
18
08
2022
accepted:
07
10
2022
pubmed:
16
10
2022
medline:
22
2
2023
entrez:
15
10
2022
Statut:
ppublish
Résumé
Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to investigate the association of fecal microbiota composition with BAT volume and activity and mean radiodensity in young adults. 82 young adults (58 women, 21.8 ± 2.2 years old) participated in this cross-sectional study. DNA was extracted from fecal samples and 16S rRNA sequencing was performed to analyse the fecal microbiota composition. BAT was determined via a static The relative abundance of Akkermansia, Lachnospiraceae sp. and Ruminococcus genera was negatively correlated with BAT volume, BAT SUVmean and BAT SUVpeak (all rho ≤ - 0.232, P ≤ 0.027), whereas the relative abundance of Bifidobacterium genus was positively correlated with BAT SUVmean and BAT SUVpeak (all rho ≥ 0.262, P ≤ 0.012). On the other hand, the relative abundance of Sutterellaceae and Bifidobacteriaceae families was positively correlated with Our results suggest that fecal microbiota composition is involved in the regulation of BAT and glucose uptake by other tissues in young adults. Further studies are needed to confirm these findings. ClinicalTrials.gov no. NCT02365129 (registered 18 February 2015).
Identifiants
pubmed: 36242744
doi: 10.1007/s40618-022-01936-x
pii: 10.1007/s40618-022-01936-x
pmc: PMC9938059
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
RNA, Ribosomal, 16S
0
Banques de données
ClinicalTrials.gov
['NCT02365129']
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-576Subventions
Organisme : Instituto de Salud Carlos III
ID : PI13/01393
Organisme : Ministerio de Ciencia e Innovación
ID : FPU13/04365
Organisme : Ministerio de Ciencia e Innovación
ID : FPU16/05159
Organisme : Ministerio de Ciencia e Innovación
ID : FPU17/01523
Organisme : Ministerio de Ciencia e Innovación
ID : Plan Propio de Investigación 2016-Excellence actions: Unit of Excellence on Exercise
Organisme : Ministerio de Ciencia e Innovación
ID : Health (UCEES)
Organisme : Academy of Finland
ID : 337530
Organisme : Consejería de Educación e Investigación
ID : ERDF
Organisme : Consejería de Educación e Investigación
ID : SOMM17/6107/UGR
Organisme : Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt
ID : Project ID: ZS/2018/11/95324
Informations de copyright
© 2022. The Author(s).
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