Resveratrol-Maltol and Resveratrol-Thiophene Hybrids as Cholinesterase Inhibitors and Antioxidants: Synthesis, Biometal Chelating Capability and Crystal Structure.
cholinesterase inhibitory activity
molecular docking
pyran-4-ones
thienostilbenes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Sep 2022
27 Sep 2022
Historique:
received:
02
09
2022
revised:
20
09
2022
accepted:
21
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
New resveratrol-thiophene and resveratrol-maltol hybrids were synthesized as cholinesterase inhibitors and antioxidants. As with photostability experiments, biological tests also found remarkable differences in the properties and behavior of thiophene and maltol hybrids. While resveratrol-thiophene hybrids have excellent inhibitory and antioxidant properties (similar to the activity of reference drug galantamine), maltols have been proven to be weaker inhibitors and antioxidants. The molecular docking of selected active ligands gave insight into the structures of docked enzymes. It enabled the identification of interactions between the ligand and the active site of both cholinesterases. The maltols that proved to be active cholinesterase inhibitors were able to coordinate Fe
Identifiants
pubmed: 36234916
pii: molecules27196379
doi: 10.3390/molecules27196379
pmc: PMC9573353
pii:
doi:
Substances chimiques
Antioxidants
0
Chelating Agents
0
Cholinesterase Inhibitors
0
Ligands
0
Pyrones
0
Thiophenes
0
Trace Elements
0
Galantamine
0D3Q044KCA
maltol
3A9RD92BS4
Cholinesterases
EC 3.1.1.8
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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