Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 10 2022
13 10 2022
Historique:
received:
13
03
2022
accepted:
03
10
2022
entrez:
13
10
2022
pubmed:
14
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal carcinoma (IDC), is an aggressive histological subtype that is associated with progression to lethal disease. To delineate the molecular and cellular underpinnings of ICC/IDC aggressiveness, this study examines paired ICC/IDC and benign prostate surgical samples by single-cell RNA-sequencing, TCR sequencing, and histology. ICC/IDC cancer cells express genes associated with metastasis and targets with potential for therapeutic intervention. Pathway analyses and ligand/receptor status model cellular interactions among ICC/IDC and the tumor microenvironment (TME) including JAG1/NOTCH. The ICC/IDC TME is hallmarked by increased angiogenesis and immunosuppressive fibroblasts (CTHRC1
Identifiants
pubmed: 36229464
doi: 10.1038/s41467-022-33780-1
pii: 10.1038/s41467-022-33780-1
pmc: PMC9562361
doi:
Substances chimiques
Apolipoproteins E
0
CTHRC1 protein, human
0
Extracellular Matrix Proteins
0
Ligands
0
Receptors, Antigen, T-Cell
0
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6036Subventions
Organisme : NIH HHS
ID : S10 OD023475
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA194024
Pays : United States
Organisme : NIH HHS
ID : S10 OD016355
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009582
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009592
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214494
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218526
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA217987
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211695
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK059637
Pays : United States
Informations de copyright
© 2022. The Author(s).
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