Dihydroceramide Δ4-Desaturase 1 Is Not Involved in SARS-CoV-2 Infection.

Animals COVID-19 Ceramides Chlorocebus aethiops Fatty Acid Desaturases Fenretinide / pharmacology Humans Oxidoreductases SARS-CoV-2 Vero Cells
N-(4-hydroxyphenyl) retinamide dihydroceramide dihydroceramide Δ4-desaturase 1 severe acute respiratory syndrome coronavirus 2

Journal

Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984

Informations de publication

Date de publication:
2022
Historique:
entrez: 2 10 2022
pubmed: 3 10 2022
medline: 5 10 2022
Statut: ppublish

Résumé

Dihydroceramide Δ4-desaturase 1 (DEGS1) enzymatic activity is inhibited with N-(4-hydroxyphenyl)-retinamide (4-HPR). We reported previously that 4-HPR suppresses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry through a DEGS1-independent mechanism. However, it remains unclear whether DEGS1 is involved in other SARS-CoV-2 infection processes, such as virus replication and release. Here we established DEGS1 knockout (KO) in VeroE6

Identifiants

DOI: 10.1248/bpb.b22-00503 PMID: 36184516
pubmed: 36184516
doi: 10.1248/bpb.b22-00503
doi:

Substances chimiques

Ceramides 0
dihydroceramide 0
Fenretinide 187EJ7QEXL
Oxidoreductases EC 1.-
Fatty Acid Desaturases EC 1.14.19.-
DEGS1 protein, human EC 1.14.99.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1559-1563

Auteurs

Yasuhiro Hayashi (Y)

Faculty of Agriculture, University of Miyazaki.

Kouki Matsuda (K)

Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute.

Kazunari Tanigawa (K)

Faculty of Pharma-Sciences, Teikyo University.

Takashi Tanikawa (T)

Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.

Kenji Maeda (K)

Division of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University.

Kiyoto Tsuchiya (K)

AIDS Clinical Center, National Center for Global Health and Medicine.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Glycosphingolipides neutres › Céramides › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Rétinoïdes › Fenrétinide › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Oxidoreductases › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Dihydroceramide Δ4-Desaturase 1 Is Not...
Recherchemedicale.com › Cellules › Cellules épithéliales › Cellules Vero › Dihydroceramide Δ4-Desaturase 1 Is Not...