mRNA-1273 SARS-CoV-2 vaccine safety and COVID-19 risk perception in recently transplanted allogeneic hematopoietic stem cell transplant recipients.
Adverse events
Allogeneic stem cell transplantation
COVID-19
Risk perception
mRNA-1273
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
25
01
2022
accepted:
21
09
2022
pubmed:
29
9
2022
medline:
6
12
2022
entrez:
28
9
2022
Statut:
ppublish
Résumé
This study aims to describe the incidence and severity of adverse events (AEs) following the mRNA-1273 SARS-CoV-2 vaccine and explore the risk perception of COVID-19 in allogeneic hematopoietic stem cell transplant (HCT) recipients. We performed a single-center prospective study including recently transplanted (< 2 years post-infusion) allogeneic HCT recipients. AEs were assessed through phone calls and graded from 0 to 4, while COVID-19 risk perception was measured using the Brief Illness Perception Questionnaire (BIP-Q5). Fifty-four HCT recipients were evaluated. Incidence and grades of AE (94.4% and 85.2% after the first and second dose, respectively) were similar to those described in the general population. The most common AE was pain at the site of injection. Three patients (5.6%) developed a grade ≥ 3 AE. Vaccine-related cytopenias and graft-versus-host disease flares were not observed. Female sex (OR 3.94, 95% CI 1.14-13.58, p = 0.03) and time since HCT (per month since HCT: OR 1.09, 95% CI 1.01-1.18, p = 0.04) were associated with the occurrence of any AE. The patients' risk perception level of COVID-19 decreased over time (p < 0.05). Our study confirms that the mRNA-1273 SARS-CoV-2 vaccine is safe in recent HCT recipients and suggests that the perceived risk of COVID-19 decreases over time.
Identifiants
pubmed: 36169731
doi: 10.1007/s00520-022-07376-w
pii: 10.1007/s00520-022-07376-w
pmc: PMC9517991
doi:
Substances chimiques
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9687-9690Subventions
Organisme : Fundació la Marató de TV3
ID : 517C/20190318/1330
Organisme : Instituto de Salud Carlos III
ID : FIS PI17/01246
Organisme : Instituto de Salud Carlos III
ID : AGAUR 2017 SGR 865
Organisme : Instituto de Salud Carlos III
ID : Tercel RD16/0011/0028
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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