PI4P and BLOC-1 remodel endosomal membranes into tubules.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
07 11 2022
07 11 2022
Historique:
received:
22
10
2021
revised:
25
07
2022
accepted:
31
08
2022
entrez:
28
9
2022
pubmed:
29
9
2022
medline:
1
10
2022
Statut:
ppublish
Résumé
Intracellular trafficking is mediated by transport carriers that originate by membrane remodeling from donor organelles. Tubular carriers contribute to the flux of membrane lipids and proteins to acceptor organelles, but how lipids and proteins impose a tubular geometry on the carriers is incompletely understood. Using imaging approaches on cells and in vitro membrane systems, we show that phosphatidylinositol-4-phosphate (PI4P) and biogenesis of lysosome-related organelles complex 1 (BLOC-1) govern the formation, stability, and functions of recycling endosomal tubules. In vitro, BLOC-1 binds and tubulates negatively charged membranes, including those containing PI4P. In cells, endosomal PI4P production by type II PI4-kinases is needed to form and stabilize BLOC-1-dependent recycling endosomal tubules. Decreased PI4KIIs expression impairs the recycling of endosomal cargoes and the life cycles of intracellular pathogens such as Chlamydia bacteria and influenza virus that exploit the membrane dynamics of recycling endosomes. This study demonstrates how a phospholipid and a protein complex coordinate the remodeling of cellular membranes into functional tubules.
Identifiants
pubmed: 36169638
pii: 213508
doi: 10.1083/jcb.202110132
pmc: PMC9524204
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Phosphatidylinositol Phosphates
0
phosphatidylinositol 4-phosphate
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Horizon 2020
ID : 101001521
Organisme : Fundação para a Ciência e a Tecnologia
Organisme : Centre National de la Recherche Scientifique
Organisme : French National Research Infrastructure France-BioImaging
ID : ANR10-INBS-04
Organisme : Labex
ID : ANR-11-LABX-0038
Organisme : Institut Curie
Organisme : National Institute of Child Health and Human Development
Organisme : Ligue Contre le Cancer
Organisme : European Research Council
Pays : International
Organisme : Instituto Gulbenkian de Ciência
Organisme : NIH HHS
ID : R01 EY015625
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY015625
Pays : United States
Organisme : Institut National de la Santé et de la Recherche Médicale
Informations de copyright
© 2022 Jani et al.
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