Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes.
Absorption
emerging pollutants
in vitro toxicology
pharmaceuticals
Journal
Environmental toxicology and chemistry
ISSN: 1552-8618
Titre abrégé: Environ Toxicol Chem
Pays: United States
ID NLM: 8308958
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
05
07
2022
received:
12
05
2022
accepted:
07
09
2022
pubmed:
15
9
2022
medline:
23
11
2022
entrez:
14
9
2022
Statut:
ppublish
Résumé
Uptake of active pharmaceutical ingredients (APIs) across the gill epithelium of fish is via either a passive or facilitated transport process, with the latter being more important at the lower concentrations more readily observed in the environment. The solute carrier (SLC) 22A family, which includes the organic cation transporter OCT2 (SLC22A2), has been shown in mammals to transport several endogenous chemicals and APIs. Zebrafish oct2 was expressed in Xenopus oocytes and the uptake of ranitidine, propranolol, and tetraethylammonium characterized. Uptake of ranitidine and propranolol was time- and concentration-dependent with a k
Identifiants
pubmed: 36102855
doi: 10.1002/etc.5480
pmc: PMC9827845
doi:
Substances chimiques
Cations
0
Organic Cation Transport Proteins
0
Organic Cation Transporter 2
0
Propranolol
9Y8NXQ24VQ
Ranitidine
884KT10YB7
Tetraethylammonium
66-40-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2993-2998Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M014827/1
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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