A neural stem cell paradigm of pediatric hydrocephalus.
cerebrospinal fluid
hydrocephalus
neural stem cell
neurodevelopmental disorders
neuroprogenitor
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
04 04 2023
04 04 2023
Historique:
received:
26
03
2022
revised:
12
07
2022
accepted:
02
08
2022
medline:
19
4
2023
pubmed:
14
9
2022
entrez:
13
9
2022
Statut:
ppublish
Résumé
Pediatric hydrocephalus, the leading reason for brain surgery in children, is characterized by enlargement of the cerebral ventricles classically attributed to cerebrospinal fluid (CSF) overaccumulation. Neurosurgical shunting to reduce CSF volume is the default treatment that intends to reinstate normal CSF homeostasis, yet neurodevelopmental disability often persists in hydrocephalic children despite optimal surgical management. Here, we discuss recent human genetic and animal model studies that are shifting the view of pediatric hydrocephalus from an impaired fluid plumbing model to a new paradigm of dysregulated neural stem cell (NSC) fate. NSCs are neuroprogenitor cells that comprise the germinal neuroepithelium lining the prenatal brain ventricles. We propose that heterogenous defects in the development of these cells converge to disrupt cerebrocortical morphogenesis, leading to abnormal brain-CSF biomechanical interactions that facilitate passive pooling of CSF and secondary ventricular distention. A significant subset of pediatric hydrocephalus may thus in fact be due to a developmental brain malformation leading to secondary enlargement of the ventricles rather than a primary defect of CSF circulation. If hydrocephalus is indeed a neuroradiographic presentation of an inborn brain defect, it suggests the need to focus on optimizing neurodevelopment, rather than CSF diversion, as the primary treatment strategy for these children.
Identifiants
pubmed: 36097331
pii: 6696466
doi: 10.1093/cercor/bhac341
pmc: PMC10110448
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4262-4279Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM136651
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA023999
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL143036
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA023999
Pays : United States
Organisme : NICHD NIH HHS
ID : F30 HD106694
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111029
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109358
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL143036
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL143036
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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